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Qaagi - Book of Why

Causes

Effects

a variety of factors including ischemia , micro - hemorrhages , gliosis ... damage to small blood vessel walls , breaches of the barrier between the cerebrospinal fluid and the brain , or loss and deformation of the myelin sheath(passive) can be caused byWhite matter hyperintensities

hypoperfusion and arteriolar disease(passive) are presumably caused byThe white matter hyperintensities

chronic ischemia due to CSVD , and that the precise spatial pattern of WMHs may indicate different underlying CSVDs(passive) are caused bywhite matter hyperintensities ( WMHs

regional hypoperfusion(passive) to be partially caused bywhite matter hyperintensities ( WMHs

vitamin deficiencyresultingin white matter hyperintensities

an exuberant migration of granule cells past the IGL / white matter border(passive) may be created byWhite matter ectopias

smokingmay ... causewhite matter hyperintensities

vascular , noninfectious , infectious , and inflammatory conditions(passive) caused bywhite matter hyperintensities

local inflammation in the brain and loss of particular types of cells that support nerve cell function(passive) may be caused byWhite matter hyperintensities

Edematous glial swelling in foci of ganglion cell heterotopiacausedsubcortical white matter hyperintensities

Learncauseswhite matter hyperintensities

Muscular dystrophy -- white matter spongiosis(passive) are caused bywhite matter spongiosis

to the presentation of Alzheimer 's disease and ... in the context of significant amyloid deposition , may provide a second hit necessary for the clinical manifestation of the diseasecontributeto the presentation of Alzheimer 's disease and ... in the context of significant amyloid deposition , may provide a second hit necessary for the clinical manifestation of the disease

to the development of late - life depressioncontributingto the development of late - life depression

to the presentation of AD and ... in the context of significant amyloid deposition , may provide a second hit necessary for the clinical manifestation of the diseasecontributeto the presentation of AD and ... in the context of significant amyloid deposition , may provide a second hit necessary for the clinical manifestation of the disease

to increased iron deposition in deep gray matter structurescan leadto increased iron deposition in deep gray matter structures

to aggravation of dementia or geriatric syndromecontributeto aggravation of dementia or geriatric syndrome

from causesother than diabetes related microvascular diseasemay resultfrom causesother than diabetes related microvascular disease

to lower cognitive functioning and presence of fatigue after TBIcontributeto lower cognitive functioning and presence of fatigue after TBI

alsocontributealso

dementia , behavioral change , delusion , psychosis , upper motor neuron weaknesscausingdementia , behavioral change , delusion , psychosis , upper motor neuron weakness

to delicate attentional network dysfunctionmay leadto delicate attentional network dysfunction

to subtle attentional network dysfunctionmay leadto subtle attentional network dysfunction

increase strokecauseincrease stroke

dementia [ brainaacn.orgcausingdementia [ brainaacn.org

limb movements in sleepmay causelimb movements in sleep

leukoariaosiscausingleukoariaosis

movement problems(passive) caused bymovement problems

striatofrontal dysfunction(passive) caused bystriatofrontal dysfunction

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