to loss of alveolar and systemic compartmentalization of TNF - αleadsto loss of alveolar and systemic compartmentalization of TNF - α

to an unacceptably high mortalityleadsto an unacceptably high mortality

to pulmonary cytokine release and acute respiratory distress syndrome ( ARDS ) alsocontributingto pulmonary cytokine release and acute respiratory distress syndrome ( ARDS ) also

to loss of alveolar and systemic compartmentalization of tumor necrosis factor - alpha Haitsma , Jack J. ; Uhlig , Stefan ; Göggel , Rolf ; Verbrugge , Serge J. ; Lachmann , Ulrike ; Lachmann , Burkhard ; Haitsma , J J ; Uhlig , S ; Göggel , R ; Verbrugge , S J ; Lachmann , U ; Lachmann , B Intensive Careleadsto loss of alveolar and systemic compartmentalization of tumor necrosis factor - alpha Haitsma , Jack J. ; Uhlig , Stefan ; Göggel , Rolf ; Verbrugge , Serge J. ; Lachmann , Ulrike ; Lachmann , Burkhard ; Haitsma , J J ; Uhlig , S ; Göggel , R ; Verbrugge , S J ; Lachmann , U ; Lachmann , B Intensive Care

to prolonged respiratory failure or death among patients with Acute Respiratory Distress Syndrome ( ARDSmay contributeto prolonged respiratory failure or death among patients with Acute Respiratory Distress Syndrome ( ARDS

to ARDS mortalitycan leadto ARDS mortality

to concomitant extrapulmonary organ dysfunctionpossibly contributingto concomitant extrapulmonary organ dysfunction

to high morbidity and mortality in these patientscan leadto high morbidity and mortality in these patients

to prolonged respiratory failure and even death among patients with acute respiratory distress syndrome ( ARDScan contributeto prolonged respiratory failure and even death among patients with acute respiratory distress syndrome ( ARDS

to the morbidity and mortality from ALI , interventions that reduce VILIcontributesto the morbidity and mortality from ALI , interventions that reduce VILI

to increased morbidity and mortality ... 1–3can leadto increased morbidity and mortality ... 1–3

to loss of alveolar and systemic compartmentalizatleadsto loss of alveolar and systemic compartmentalizat

in systemic effects with multi - system organ failuremay resultin systemic effects with multi - system organ failure

to the morbidity and mortality of patients with acute lung injurycan contributeto the morbidity and mortality of patients with acute lung injury

to mortality in patients with acute respiratory distress syndrome , the most severe form of acute lung injury ( ALIcontributesto mortality in patients with acute respiratory distress syndrome , the most severe form of acute lung injury ( ALI

Nadine Houédé Elevation of Serum Carcinoembryonic Antigen Concentration(passive) Caused byNadine Houédé Elevation of Serum Carcinoembryonic Antigen Concentration

to loss of alveolar and systemic compartmentalization of tumor necrosis factoralphaleadsto loss of alveolar and systemic compartmentalization of tumor necrosis factoralpha

in serious sequela , such as bronchopulmonary dysplasia ( BPDmay ... resultin serious sequela , such as bronchopulmonary dysplasia ( BPD

the development of bronchopulmonary dysplasia ( BPD ) in large portioncausesthe development of bronchopulmonary dysplasia ( BPD ) in large portion

the inflammatory cascade , which may progress to BPD.[7]–[13can triggerthe inflammatory cascade , which may progress to BPD.[7]–[13

to the progression of ALI / ARDS,1contributesto the progression of ALI / ARDS,1

to serious conditions like ARDS which are associated with a high mortality ( around 30 % , Stapleton et al . , Chest , 2005can leadto serious conditions like ARDS which are associated with a high mortality ( around 30 % , Stapleton et al . , Chest , 2005

to systemic ( 9–11 ) and brain ( 12 , 13 ) inflammation and injuryleadsto systemic ( 9–11 ) and brain ( 12 , 13 ) inflammation and injury

in mice by deletion of the calcium - permeable stretch - activated transient receptor potential vanilloid-4 ( TRPV4 ) ion channelwas preventedin mice by deletion of the calcium - permeable stretch - activated transient receptor potential vanilloid-4 ( TRPV4 ) ion channel

pulmonary edema , decreasing lung compliance and promoting lung inflammation due to increased cytokine production and lung neutrophil accumulation.30 Magnesium sulphatecausingpulmonary edema , decreasing lung compliance and promoting lung inflammation due to increased cytokine production and lung neutrophil accumulation.30 Magnesium sulphate

significant lung vascular leak detected by Evans blue dye accumulation in the lung parenchyma , which was evident in Asef+/+ and Asef−/− mice after 4 h of HTVcausedsignificant lung vascular leak detected by Evans blue dye accumulation in the lung parenchyma , which was evident in Asef+/+ and Asef−/− mice after 4 h of HTV

from mechanical disruption of blood - gas barrier and consequent edema and releases of inflammatory mediatorsresultsfrom mechanical disruption of blood - gas barrier and consequent edema and releases of inflammatory mediators

to accumulation of fluid in the lungs and increased susceptibility to infectioncan leadto accumulation of fluid in the lungs and increased susceptibility to infection

from relatively high tidal volumes ( VTresultsfrom relatively high tidal volumes ( VT

markedly to lung damage in immature lungs and that the deleterious effect of assisted ventilation is more related to the volumes than to the pressurescontributesmarkedly to lung damage in immature lungs and that the deleterious effect of assisted ventilation is more related to the volumes than to the pressures

a systemic inflammatory response and result in multi - organ failure.7can triggera systemic inflammatory response and result in multi - organ failure.7

from repetitive closing and opening of collapsed alveolar units , or from pulmonary overdistensionto resultfrom repetitive closing and opening of collapsed alveolar units , or from pulmonary overdistension

from alveolar over - distention ( volutraumaresultingfrom alveolar over - distention ( volutrauma

to the development of organ failure and death ( 1can contributeto the development of organ failure and death ( 1

significantlycontributessignificantly

from high lung volumes ( volutrauma ) , high airway pressures ( barotrauma ) , and repetitive opening and closing of collapsed lung units ( atelectraumaresultsfrom high lung volumes ( volutrauma ) , high airway pressures ( barotrauma ) , and repetitive opening and closing of collapsed lung units ( atelectrauma

to postoperative pulmonary complications through mechanisms including volutrauma , barotrauma , and atelectasisleadingto postoperative pulmonary complications through mechanisms including volutrauma , barotrauma , and atelectasis

from oxygen toxicity , biotrauma , atelectrauma , and volutraumamay resultfrom oxygen toxicity , biotrauma , atelectrauma , and volutrauma

to substantial aggravation of previously established severe pneumonia resulting in acute respiratory failure , which was accompanied by elevation of pulmonary cytokine levels independent from leukocyte recruitment or bacterial replication in the lungledto substantial aggravation of previously established severe pneumonia resulting in acute respiratory failure , which was accompanied by elevation of pulmonary cytokine levels independent from leukocyte recruitment or bacterial replication in the lung

to organ dysfunction and death ... 1can contributeto organ dysfunction and death ... 1