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Qaagi - Book of Why

Causes

Effects

Researchersdiscoverpossible treatment for ventilator - induced lung injuries

Mechanical ventilation with large tidal volume ( VTcausesacute lung injury ( ventilator - induced lung injury ( VILI

delivering too large a tidal volume(passive) caused bya form of ventilator induced lung injury ( VILI

by high tidal volume ventilation(passive) caused byventilator - induced lung injury ( VILI

high tidal volume ( Vt ) MVcan causeventilator - induced lung injury ( VILI

Mechanical ventilation with high tidal volumesmay causeventilator - induced lung injury ( VILI

a pathogenetic factorleadingto the so - called ventilator - induced lung injury ( VILI

High tidal volumecan causeventilator - induced lung injury ( VILI

Mechanical ventilation ( MVmay causeventilator - induced lung injury ( VILI

Mechanical ventilation ( MVcan causeventilator - induced lung injury ( VILI

Alveolar instabilitycausesearly ventilator - induced lung injury

mechanical ventilationcan ... leadto ventilator - induced lung injury ( VILI

mechanical ventilationcan resultin ventilator - induced lung injury ( VILI

lungsresultsin Ventilator Induced Lung Injury ( VILI

Mechanical ventilationcan causeventilator - associated lung injury ( VALI

Mechanical ventilation can contribute to lung injuryresultingin ventilator - induced lung injury ( VILI

Mechanical ventilationcausingventilator - induced lung injury increases

a more homogenous distribution of airway pressures and tidal volumes , preventing barotrauma / volutrauma and " atelectraumaresultingin less ventilator - induced lung injury

inflammationresultingin ventilator - induced lung injury ( VILI

these settingsmay ... causeventilator - induced lung injury ( VILI

Improperly - provided ventilationmay resultin ventilator - induced lung injury ( VILI

by volutrauma and barotrauma(passive) is causedventilator - induced lung injury ( VILI

the primary factorscontributeto ventilator - induced lung injury ( VILI

Repeated alveolar collapse and cyclic alveolar overdistension with associated activation of inflammatory signalling cascadescontributeto ventilator - induced lung injury ( VILI

More aggressive ventilation ... likelyto resultin worsening ventilator - induced lung injury

Large tidal volumes used in positive pressure ventilation in normal lungscan causeventilator - induced lung injury

PEEP that is too high or low can cause damage to healthy alveolileadingto ventilator induced lung injury ( VILI

Mechanical ventilation using high tidal volume ( VT ) and transpulmonary pressure can damage the lungcausingventilator - induced lung injury

increased tidal volume and alveolar pressurecould contributeto ventilator - induced lung injury

airway pressure and lung volumesresultingin ventilator induced lung injury

acute lung injury mechanical ventilationcan causeventilator associated lung injury

acute lung inflammationresultingin ventilator - induced lung injury

Other description about permissive hypercapnia in ARDS patient Mechanical ventilation using high tidal volume ( VT ) and transpulmonary pressure can damage the lungcausingventilator - induced lung injury

pneumonia and mechanical ventilationcausingventilator - induced lung injury

transpulmonary pressure can damage the lungcausingventilator - induced lung injury

by high PIP and high tidal volumes(passive) caused byventilator - induced lung injury

high PIP and high tidal volumes(passive) caused byventilator - induced lung injury

the potential mechanismscausingventilator - induced lung injury

Pulmonary inflammationcontributesto ventilator - induced lung injury

Mechanical ventilation ( MVcan leadto ventilator - induced lung injury

inflammationto causeinflammation

to overdistention of lung units ( volutraumaleadto overdistention of lung units ( volutrauma

to the high mortality rates associated with ARDScontributesto the high mortality rates associated with ARDS

to multisystem organ failure.27can leadto multisystem organ failure.27

in ' ventilator - associated heart injurycan ... resultin ' ventilator - associated heart injury

to acute respiratory distress syndromecan leadto acute respiratory distress syndrome

severe hypoxemia and resultant cerebral hypoxiacausingsevere hypoxemia and resultant cerebral hypoxia

the damage(passive) caused bythe damage

in a spectrum of diseases from the acute respiratory distress syndrome ( ARDS ) to idiopathic pulmonary fibrosis ( IPFmay resultin a spectrum of diseases from the acute respiratory distress syndrome ( ARDS ) to idiopathic pulmonary fibrosis ( IPF

to mortalitycontributesto mortality

from even brief periods of mechanical ventilationcan resultfrom even brief periods of mechanical ventilation

to CD73-mediated increases in extracellular adenosine , which are detrimental to the newborn lungleadsto CD73-mediated increases in extracellular adenosine , which are detrimental to the newborn lung

in significant increases of protein contained in BALFresultedin significant increases of protein contained in BALF

progression to acute respiratory distress syndromecausingprogression to acute respiratory distress syndrome

to mortalitycan contributeto mortality

to serious conditions like ARDS which are associated with a high mortality ( around 30 % , Stapleton et al . , Chest , 2005can leadto serious conditions like ARDS which are associated with a high mortality ( around 30 % , Stapleton et al . , Chest , 2005

from the hyperinflation of alveoli past the rupture pointresultsfrom the hyperinflation of alveoli past the rupture point

the development of bronchopulmonary dysplasia ( BPD ... in large portioncausesthe development of bronchopulmonary dysplasia ( BPD ... in large portion

the development of bronchopulmonary dysplasia ( BPD ) in large portioncausesthe development of bronchopulmonary dysplasia ( BPD ) in large portion

from the repeated opening and closure of the terminal bronchioles during each respiratory cycleresultingfrom the repeated opening and closure of the terminal bronchioles during each respiratory cycle

from alveolar over - distention ( volutrauma ) due to low lung compliance and high ventilatory pressures combined with repeated alveolar collapse and re - expansion ( atelectrauma ) , and oxygen toxicityresultingfrom alveolar over - distention ( volutrauma ) due to low lung compliance and high ventilatory pressures combined with repeated alveolar collapse and re - expansion ( atelectrauma ) , and oxygen toxicity

from choice of ventilation modes or strategies that do not limit inspiratory pressures and deliver tidal volumes based on predicted body weight[31 , 32may resultfrom choice of ventilation modes or strategies that do not limit inspiratory pressures and deliver tidal volumes based on predicted body weight[31 , 32

to loss of alveolar and systemic ventilator - induced lung injuryleadsto loss of alveolar and systemic ventilator - induced lung injury

to serious conditions like ARDS which are associated with a high mortality ( around 30 % , Stapleton et al . , Chest , 2005can leadto serious conditions like ARDS which are associated with a high mortality ( around 30 % , Stapleton et al . , Chest , 2005

the development of bronchopulmonary dysplasia ( BPD ) in large portioncausesthe development of bronchopulmonary dysplasia ( BPD ) in large portion

in pleurisy characterized by fluid accumulationresultingin pleurisy characterized by fluid accumulation

from direct injurymay resultfrom direct injury

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