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Qaagi - Book of Why

Causes

Effects

the ability of VEGFto triggervascular permeability

histamine and the other mediators(passive) caused byvascular permeability

the liberation of mediatorsleadsto an increase in vascular permeability

VEGF injection ( 50(passive) caused byvascular permeability

ovarian hypersecretion of VEGF(passive) caused byincreased vascular permeability

VEGF and inflammatory agents(passive) caused byvascular permeability

Vascular Endothelial Growth Factor ( VEGF ) , a molecule in the eyeleadsto increased vascular permeability

mediators such as serotonin or histamine at the microcirculatory level(passive) caused bythe increased vascular permeability

which damage endothelial cells of the lung capillaries ,leadingto increased vascular permeability

vascular endothelial growth factor ( VEGF ) production by granulosa cells and endothelial cellsresultsin increased vascular permeability

It binds to VEGF receptor ( VEGFR ) on endothelial cells ,leadingto increased vascular permeability

inflammatory mediators [ 48(passive) caused byincreased vascular permeability

release of primary mediators(passive) caused byvascular permeability

elevation of inflammatory mediatorscauseincreased vascular permeability

the production of vascular endothelial growth factor ( VEGF ) , which is the key mediatorleadsto increased vascular permeability

the microcirculatory changes and release of inflammatory mediators(passive) caused byvascular permeability

mediators such as serotonin or histamine in the microcirculation · Stimulation of endogenous fibrinolytic potential(passive) caused byincreased vascular permeability

The barrier ... endothelial cellsresultsin increase vascular permeability

VEGF expression and other pro - inflammatory cytokinescausevascular permeability

periodic elevation of ... releasing mediatorscauseincrease vascular permeability

Multiple mast cell mediatorscausean increase in vascular permeability

VEGF - induced tyrosine phosphorylation of VE - cadherinresultedin increased vascular permeability

allergic mediators such as histamine , serotonin , and leukotriene C4 in rats ( 18(passive) caused bythe increased vascular permeability

VEGF levels ... especially the VEGF 121 isoformcausesvascular permeability

Direct injury to endothelial cellscan also causeincreased vascular permeability

Hantavirus infection of endothelial cellsleadsto increased vascular permeability

Endothelial cells are damaged by IRIleadingto increased vascular permeability

proangiogenic and inflammatory cytokines 's activation is often coupled with upregulation of VEGF - Acausingincreased vascular permeability

the release of histamine from mast cells(passive) caused bythe increased vascular permeability

inflammation in the elderly(passive) caused byan increased vascular permeability

A mediator of inflammation andcausesincrease in vascular permeability

Damage to the endothelial cells that are responsible for maintaining the blood - retinal barrier ( BRBleadsto increased vascular permeability

passive cutaneous anaphylaxis , allergic mediators , and mediator releasers in rats(passive) caused byincreased vascular permeability

Inflammation , ischemia , and reperfusion activate endothelial cells , leukocytes , and platelets , which produce oxygen radicals and inflammatory mediatorscausingincreased vascular permeability

22 Capillary leakage ... the involved inflammatory mediatorscan causean increase in vascular permeability

passive cutaneous anaphylaxis and some chemical mediators in rats(passive) caused byincreased vascular permeability

these various preformed and newly generated mediators ... likelyto createan increase in vascular permeability

whether administration of PEG liposomes induced release of vasoactive mediatorsresultingin increased vascular permeability

that low vascular volume resulted in hypoxia , which in turn increased VEGF expression in these regionsleadingto increased vascular permeability

release of histamine from conjunctival mast cells(passive) caused byincreased vascular permeability

retinal oedemacausingretinal oedema

to the development of macular edemacontributingto the development of macular edema

in vascular leakage and macular edemaresultingin vascular leakage and macular edema

fluid to escape from capillaries into tissues , which leads to the classic symptoms of an allergic reaction — a runny nose and watery eyescausingfluid to escape from capillaries into tissues , which leads to the classic symptoms of an allergic reaction — a runny nose and watery eyes

in macular edema and decreased visionresultsin macular edema and decreased vision

pulmonary edema Increasedcausespulmonary edema Increased

to noncardiogenic pulmonary edemaleadsto noncardiogenic pulmonary edema

to pulmonary edema [ 3leadingto pulmonary edema [ 3

in systemic and/or pulmonary edemaresultingin systemic and/or pulmonary edema

to diffuse pulmonary edemaleadingto diffuse pulmonary edema

to pulmonary edema ( 29leadingto pulmonary edema ( 29

a local oedemacausinga local oedema

to pulmonary oedemaleadingto pulmonary oedema

to capillary leaks and pulmonary edemaleadingto capillary leaks and pulmonary edema

to noncardio- genic pulmonary edemaleadingto noncardio- genic pulmonary edema

fluid accumulation in the fovea ( diabetic macular edema DME(passive) caused byfluid accumulation in the fovea ( diabetic macular edema DME

to macular edema and development of neovascularization ( 1 , 4 , 5 , 8)leadingto macular edema and development of neovascularization ( 1 , 4 , 5 , 8)

to plasma leakage syndromeleadingto plasma leakage syndrome

to hemoconcentration and hypovolemic shock [ 3leadingto hemoconcentration and hypovolemic shock [ 3

tissue oedema and promoting mucus formationcausingtissue oedema and promoting mucus formation

in tissue edema and organ dysfunction ( 58resultingin tissue edema and organ dysfunction ( 58

to systemic edemaleadingto systemic edema

in mucosal edemaresultingin mucosal edema

to the development of oedema.23contributesto the development of oedema.23

hemorrhagic manifestations and plasma leakage(passive) caused byhemorrhagic manifestations and plasma leakage

in plasma leakage and hemorrhages ( 2resultingin plasma leakage and hemorrhages ( 2

to loss of intravascular fluid volume and hypotension during anaphylactic reactionscan leadto loss of intravascular fluid volume and hypotension during anaphylactic reactions

to pulmonary edema and protein leak into the alveolar spacesledto pulmonary edema and protein leak into the alveolar spaces

pulmonary edema and ultimately lead to respiratory failuremay triggerpulmonary edema and ultimately lead to respiratory failure

to hypovolemia and shockleadingto hypovolemia and shock

to glomerulations , edema , and inflammationleadingto glomerulations , edema , and inflammation

alveolar edema formation(passive) caused byalveolar edema formation

to protein leakage and edema ( 22leadsto protein leakage and edema ( 22

in severe pulmonary edema and lung injury ( 4–7resultingin severe pulmonary edema and lung injury ( 4–7

vasogenic brain edemacausingvasogenic brain edema

in the onset of macular oedema [ 2resultingin the onset of macular oedema [ 2

to oedema in lung injury.66contributesto oedema in lung injury.66

redness and oedema at the site of infectioncausingredness and oedema at the site of infection

brain oedema in other clinical settingscausingbrain oedema in other clinical settings

to the development of diabetic macular edema , which is the major cause of vision loss in patients with diabetic retinopathyleadsto the development of diabetic macular edema , which is the major cause of vision loss in patients with diabetic retinopathy

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