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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

the abilityto causeincreased vascular permeability , vasodilation

The neuropeptidescan causean increase vascular permeability and vasodilation

acute diffuse , inflammatory lung injuryleadingto increased pulmonary vascular permeability

ARDS Pathogenesis ARDS is characterized as an acute diffuse , inflammatory lung injuryleadingto increased pulmonary vascular permeability

We all knowcausesincreased vascular permeability in angiogenesis

which in turn increased VEGF expression in these regionsleadingto increased vascular permeability

increased VEGF and NO production in hypoxiahad resultedin increased vascular permeability

The increased VEGF expressioncausesthe increased vascular permeability

Increased bradykinin levelsleadto an increase in vascular permeability

induced vascular endothelial cell injury and focal lossresultingin increased vascular permeability

The process of inflammationcausesincreased vascular permeability

early in acute inflammation(passive) is causedThe increased vascular permeability

Its activation is often coupled with upregulation of VEGF - Acausingincreased vascular permeability

hypoxia trigger VEGF expressionleadingto increased vascular permeability

The acute inflammationcausesan increase in the vascular permeability

2 ] VEGF is thoughtto causeincreased vascular permeability

Endothelial injury and dysfunction ,causingincreased vascular permeability

by endothelial cell injury and disruption of cellular junctions(passive) caused byIncreased vascular permeability

3 ] VEGF is thoughtto causeincreased vascular permeability

Repeated endothelial damagemay causeincreased vascular permeability

the factorscauseincreased vascular permeability

Factorscausingincreased vascular permeability

by these cells(passive) caused byincreased vascular permeability

Damage to the endothelium of the pulmonary microvasculature is thoughtto causeincreased vascular permeability

These cells , as a result of IL-2 bindingcausesincreased vascular permeability

by inflammation(passive) caused byincreased vascular permeability

the action ... local re actioncauseincreased vascular permeability

inflammation(passive) is caused byAn increase in vascular permeability

endothelial cells or other structural components of the alveolar - capillary membraneresultsin increased vascular permeability

activation of protein kinase Cleadsto increase vascular permeability

inflammatory pathwayscausingincreased vascular permeability

The release of mediatorscausesincreased vascular permeability

e.g. , an inhibitor of Vascular Endothelial Growth Factor ( VEGF ... the VEGF signalling pathwayleadsto increased vascular permeability

injury ... the alveolar - capillary membraneresultsin increased vascular permeability

inflammatory substances ( histamine , bradykininresultsin increased vascular permeability

endothelial cell damageresultsin increased vascular permeability

Administration of anti - VE - cadherin antibody to micecausedincrease in vascular permeability

In addition , tight junction proteins appear to be down - regulated ,leadingto an increase in vascular permeability

infectionleadingto increased vascular permeability

at capillary levelcauseincreased vascular permeability

to edema ( swellingleadsto edema ( swelling

to vasodilation , hypotension , and edemaleadingto vasodilation , hypotension , and edema

to chronic airway edema which leads to mucosal thickening and swelling of the airwayleadsto chronic airway edema which leads to mucosal thickening and swelling of the airway

to retinal edema and capillary closure leading to retinal ischemia and new vessel growthleadingto retinal edema and capillary closure leading to retinal ischemia and new vessel growth

to edema formation in peripheral tissueleadingto edema formation in peripheral tissue

pulmonary edema Increased vascular permeability causes pulmonary edema Pathologycausespulmonary edema Increased vascular permeability causes pulmonary edema Pathology

to loss of intravascular fluid volume and hypotensioncan leadto loss of intravascular fluid volume and hypotension

to an increase of fluid in the lung , and also acts to up - regulate adhesion molecules on the local vascular endotheliumleadingto an increase of fluid in the lung , and also acts to up - regulate adhesion molecules on the local vascular endothelium

to edema formationleadingto edema formation

in edema formationresultsin edema formation

in vascular leakage and macular edemaresultingin vascular leakage and macular edema

loss of fluid and proteincausingloss of fluid and protein

to loss of fluid from the circulationleadsto loss of fluid from the circulation

to edema from vascular leaking of plasma , which can cause cerebral edema and proteinurialeadsto edema from vascular leaking of plasma , which can cause cerebral edema and proteinuria

to a loss of plasma volumeleadingto a loss of plasma volume

in leakage of edema fluid , fibrin , and sometimes hemorrhageresultingin leakage of edema fluid , fibrin , and sometimes hemorrhage

to the development of macular edemacontributingto the development of macular edema

to a fall in blood pressure , shock and deathcan leadto a fall in blood pressure , shock and death

in tissue edemaresultingin tissue edema

the loss of fluidcausingthe loss of fluid

to loss of fluidleadingto loss of fluid

to loss of fluidleadsto loss of fluid

cerebral edema(passive) caused bycerebral edema

to vascular leakage , hypovolemia , and shockleadingto vascular leakage , hypovolemia , and shock

in leakage of edema fluid , fibrin , and sometimesresultingin leakage of edema fluid , fibrin , and sometimes

fluid shift from intra - vascularcausingfluid shift from intra - vascular

to capillary leakage and edemaleadsto capillary leakage and edema

in edema ... vasodilation , tachycardia , and increased cardiac outputresultsin edema ... vasodilation , tachycardia , and increased cardiac output

to edema and finally cardiovascular shock ( 1can leadto edema and finally cardiovascular shock ( 1

more mucosal edema formationcausesmore mucosal edema formation

to edema ( swellingleadsto edema ( swelling

in leakage of edema fluid , fibrin , and sometimes hemorrhage.(6resultingin leakage of edema fluid , fibrin , and sometimes hemorrhage.(6

in swelling and a decrease in blood pressureresultingin swelling and a decrease in blood pressure

tissue oedemacausingtissue oedema

to retinal edema , or ( 2leadingto retinal edema , or ( 2

in tissue edema and organ dysfunctionresultingin tissue edema and organ dysfunction

the characteristic swelling of tissuescausesthe characteristic swelling of tissues

the leakage of fluidcausingthe leakage of fluid

an influx of plasma into the site of inflammationcausesan influx of plasma into the site of inflammation

the observed fall in gas exchange and development of acute pulmonary oedemacausingthe observed fall in gas exchange and development of acute pulmonary oedema

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