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the factorscontributeto inter - individual variability in drug response
genetic componentscontributeto inter - individual variability in drug response
Genetic backgroundinfluencingdrug effect and variability in drug response
the least explored factorscontributingto the inter - individual variability in drug response
genetic factorscontributeto inter - individual variability in drug response
the genetic variationsinfluenceinter - patient variability in drug response
a single polymorphismdoes ... causesignificant variation in drug response
Pharmacokinetic factorsinfluencingvariability in human drug response
The epigenetic regulation of expression of genes involved in the absorption , distribution , metabolism , and excretion ( ADME ) of drugscontributesto inter - individual variability in drug response
an important factorcontributingto individual variation in drug response
a pharmaceutical effect and factorsinfluencedrug disposition leading to variation in drug response
imperfect compliancewill causesignificant variability in drug response
a standard doseresultsin wide variation in drug response
common genetic variation in the proximal promoter regions of transporter genescontributeto observed variation in drug response
a standard doseresultsin broad variation in drug response
a regular doseresultsin broad variation in drug response
gene variantscausingdifferences in drug response
common genetic polymorphismsmay contributeto interindividual variability in drug response
more than one genetic variantmay contributeto variation in drug response
a recognition ... more than one genetic variantmay contributeto variation in drug response
a common genetic polymorphismcontributesto interindividual variability in drug response
factorscontributeto the interindividual variability in drug response
potential mechanismscontributingto interindividual variability in drug response
other factorscontributingto variation in drug response
new factorscontributingto variability in drug response
the resulting variation in gene expressionleadsto variation in drug response
genescausevariation in drug response
genetic and non - genetic factorscontributeto variability in drug response
The mechanismsleadingto antiplatelet drug response variability
a factorcan contributeto interindividual variability of drug response
Discussion Understanding in a comprehensive manner the genetic risk factorscontributingto variation in drug response
the factorscontributeto variability of drug response
the factorscontributeto variability in drug response
the factorscontributingto variability in drug response
factorscontributeto variability in drug response
Genetics ... the factorscontributeto variability in drug response
the drug metabolismleadingto variability in drug response
the genetic risk factorscontributingto variation in drug response
pharmacodynamic factorscausingvariation in drug response
Delays or drug loss during absorptionmay contributeto variability in drug response
the treatment of several diseases ( 4,6influencingthe treatment of several diseases ( 4,6
from environmental factorsto resultfrom environmental factors
to intensive efforts in the discovery of such biomarkershas ledto intensive efforts in the discovery of such biomarkers
serious side effects or ineffectiveness(passive) caused byserious side effects or ineffectiveness
in 90 % inhibition of the target enzymeresultingin 90 % inhibition of the target enzyme
from inherited differences in drug sensitivitycan resultfrom inherited differences in drug sensitivity
to high variability in the efficacy of chemotherapy treatment and the side effects that are associated with cytotoxic drugscan leadto high variability in the efficacy of chemotherapy treatment and the side effects that are associated with cytotoxic drugs
pharmacokinetic parametersmay influencepharmacokinetic parameters
in 90 % stoppage of the target enzymeresultsin 90 % stoppage of the target enzyme
in four taxonomic groupsresultsin four taxonomic groups
viral replicationcausesviral replication
viral replication orcausesviral replication or
Sincemay be causedSince
inactivation of the drug or other adverse clinical eventscan causeinactivation of the drug or other adverse clinical events
medical condition(passive) caused bymedical condition
the rejectionwould ... causethe rejection
from antigen - antibody reactionresultingfrom antigen - antibody reaction
to differences in dosingcould leadto differences in dosing
both efficacy and safetymay influenceboth efficacy and safety
users to seek products with higher potencyleadsusers to seek products with higher potency
to reinforcementleadto reinforcement
to hepatic failure ( see PRECAUTIONS , General , Hepatic Effectsleadingto hepatic failure ( see PRECAUTIONS , General , Hepatic Effects
to differences in drug efficacymay leadto differences in drug efficacy
to acute hepatitisleadingto acute hepatitis
to hepatic failure ( see PRECAUTIONS , Generalleadingto hepatic failure ( see PRECAUTIONS , General
to differences in drug efficacy and safetymay leadto differences in drug efficacy and safety
in the preclinical testing of several clinically approved drugs that could be repurposed for the treatment of head and neck cancerhas resultedin the preclinical testing of several clinically approved drugs that could be repurposed for the treatment of head and neck cancer
very nature a drug regimens of oral concentratecan causevery nature a drug regimens of oral concentrate
to precise and strong treatment of cancer diseasesleadto precise and strong treatment of cancer diseases
to the development of a new field in biomedical science calledhas ledto the development of a new field in biomedical science called
to hepatic failure ( see PRECAUTIONS , General : Pioglitazone hydrochlorideleadingto hepatic failure ( see PRECAUTIONS , General : Pioglitazone hydrochloride
rash , fever , inflammation of internal organs , hematologic abnormalities and systemic sicknesscausesrash , fever , inflammation of internal organs , hematologic abnormalities and systemic sickness
for all students , recent graduates , and new researchers in the pharmaceutical and biotechnology industries who need tois designedfor all students , recent graduates , and new researchers in the pharmaceutical and biotechnology industries who need to
for all students , recent graduates , and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substanceis designedfor all students , recent graduates , and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance
total remissioncan causetotal remission
the overall process of finding the correct SNP to be very expensive and time - consuming and resource intensive as wellcausesthe overall process of finding the correct SNP to be very expensive and time - consuming and resource intensive as well
to increased risk of overdosecould leadto increased risk of overdose
to failurecan leadto failure
to different outcomesleadsto different outcomes
to the development of more potent P2Y12 inhibitors such as prasugrel and ticagrelorhas ledto the development of more potent P2Y12 inhibitors such as prasugrel and ticagrelor