Genetic an environmental factorscausingvariability in psychotropic drug response
many factorscan ... contributeto variability in drug response
Genetics ... the factorscontributeto variability in drug response
quantify factorsinfluencesvariability in drug response
Clinical , environmental , and genetic factorscontributeto variability in drug response
genetic and non - genetic factorscontributeto variability in drug response
1985 Pharmacokinetic factorsinfluencingvariability in human drug response
B. " Pharmacokinetic factorsinfluencingvariability in human drug response
the identification of genomic factorsinfluencingvariability in drug response
198139:5 - 14 pharmacokinetic factorsinfluencingvariability in human drug response
how individual gene variationscausevariability in drug responses
other potential patient - related factors such as age , smoking behaviour , renal and liver functioncould ... contributeto the variability in drug response
the genes and mutations in these genescausingvariation in drug response
how genetic ( genome ) differences in MULTIPLE genesinfluencevariability in drug response
genetic variation in any of the genes regulating this pathwaymay causevariation in drug response
4 Plasma Binding Proteins Several physiological or pathological conditions including renal failure , cirrhosis , and inflammatory states , can modify the circulating level of goлd binding good trading strategy forex teins , mainly serum albumin and a1-acid glycoproteinresultingin drug response variability
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Variations in genes involved in drug disposition and in eliciting drug responsesignificantly contributeto the interpatient variability in drug response
variations in molecular function conferred by polymorphisms ( and mutations ) in one or more genes modulating drug actionscausevariability in drug response
specific genes and gene products associated with various Identifying genes and allelic variants of genesleadsto variability in drug response
besides genetic variation in genes encoding enzymes / proteins and transporters involved in the pharmacokinetics and pharmacodynamics ( pharmacogeneticscontributeto variability of drug response
Pharmacogenomic variants are knownto influencevariation in drug response
The activity level of these enzymes varies from one person to the nextleadingto variability in drug response
genomic heterogeneityleadsto variability in drug responses
knowledge about genetic differences , or polymorphismscontributeto variability in drug responses
Molecular mechanismscontributingto variability in drug response
An important aspectcontributesto variability in drug response
Interindividual differences in drug transporter expressioncan resultin variability in drug response
This ‘ one - dose - fits - all ’ approachleadsto variability in drug response
the drug metabolismleadingto variability in drug response
This could be different in different strains of Leishmania , as well as in different infected individuals ,leadingto variability in drug response
assumedto causedrug response variability
Information regarding patient characteristics ( e.g. , age , ethnicity , renal / hepatic function , concomitant disease , etc . ) knownto contributeto variability in drug response
Because every tumor exhibits a unique constellation of genomic alterations , regardless of the tissue of origin , and genomiccan leadto variability in drug responses
CYP ) enzyme systemcontributeto variability in drug response
key genetic variantsinfluencingvariation in drug response
genetic variabilitycontributesto the variability in drug response
the processescontributingto variability in drug response
to therapeutic failure ( eg , ultrarapid metabolizers ) and adverse drug responses ( poor metabolizerscan leadto therapeutic failure ( eg , ultrarapid metabolizers ) and adverse drug responses ( poor metabolizers
to therapeutic failure ( eg , ultrarapid metabolizers ) and adverse drug responses ( poor metaboliz- erscan leadto therapeutic failure ( eg , ultrarapid metabolizers ) and adverse drug responses ( poor metaboliz- ers
both efficacy and safetymay influenceboth efficacy and safety
to variation in drug safety and efficacyleadsto variation in drug safety and efficacy
in differences in clinical efficacymay resultin differences in clinical efficacy
partly from geneticsoriginatespartly from genetics
largely from genetically determined differences in 89 % of serum sicknessmay resultlargely from genetically determined differences in 89 % of serum sickness
the economic and societal burden(passive) caused bythe economic and societal burden
treatment failurecausestreatment failure
in very serious nega - tive consequencescan resultin very serious nega - tive consequences