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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

GABA Acauseshyperpolarization ( inhibition

DNA methylationcausestranscriptional inhibition

GSK3-mediated phosphorylationscausetranscriptional inhibition

relatedto promptVEGF inhibition

by any mechanism(passive) caused byproteasome inhibition

retrograde signal from metabotropic glutamate to cannabinoid receptors(passive) caused byPresynaptic inhibition

Activation of GABAB receptorscausespresynaptic inhibition

malayamycin treatment(passive) caused bysporulation inhibition

by BTZ treatment(passive) caused byproteasome inhibition

MG132 treatment increased levels of high molecular weight polyubiquitinated proteins after 4 and 16 h(passive) caused byproteasome inhibition

that has previously been shownto causepresynaptic inhibition

MG132(passive) caused byproteasome inhibition

by retrograde signal(passive) caused byPresynaptic inhibition

NAD+ depletion(passive) caused bySIRT1 inhibition

Nutrient insufficiency ... in whichcausesmTOR inhibition

This primary afferent depolarizationcausespresynaptic inhibition

endogenous adenosine(passive) caused bypresynaptic inhibition

by noradrenaline(passive) caused bypresynaptic inhibition

Enkephalincausespresynaptic inhibition

evidencecan influenceGABAergic inhibition

by water(passive) caused byvagal Inhibition

Histoneleadsdeacetylase inhibition

a sudden shockcausingvagal inhibition

a sudden shock ... orcausingvagal inhibition

> High dosescan causeCox-1 inhibition

High dosescan causeCox-1 inhibition

either L - NAME or N - PLA(passive) caused byNOS1 inhibition

Vilitra ... generic as VardenafilcausesPDE5 inhibition

poisoning(passive) caused bythepetitive inhibition

By selectively exciting A - beta nerve fibres in the skin with TENS , the amount of painful stimulation being transmitted by smaller diameter A - delta and C - fibres can be reducedcausingsegmental inhibition

the mechanism of the P450-catalyzed conversion of NMH ... a nitrosomethane intermediatecausesP450 inhibition

lot of things that physical therapists , physicians , strength and conditioning experts , and coaches docauseneuromuscular inhibition

The aim of achieving a satisfactory statement given of source of stored serotonin amfetamine , cocaine , fenu- ramine , mdma , meperidineleadsreuptake inhibition

in decreased cellular proliferationwill resultin decreased cellular proliferation

to complement activationmay contributeto complement activation

regression of established vesselsdoes ... causeregression of established vessels

to stabilization of actinleadsto stabilization of actin

neurodegenerationcausesneurodegeneration

Gastrointestinal perforation(passive) can be caused byGastrointestinal perforation

to drug - drug interactions , toxicity , and other adverse effectsmay leadto drug - drug interactions , toxicity , and other adverse effects

to an accumulation of misfolded proteins in the cell resulting in endoplasmic reticulum ( ER ) stresswould leadto an accumulation of misfolded proteins in the cell resulting in endoplasmic reticulum ( ER ) stress

morphometric changes in the bowel mucosa [ 15 , 16may causemorphometric changes in the bowel mucosa [ 15 , 16

This phenotype(passive) is caused byThis phenotype

to the loss of the 3leadsto the loss of the 3

or not the increase of ubiquitinated proteins following niclosamide treatment(passive) is caused byor not the increase of ubiquitinated proteins following niclosamide treatment

a reduction in cellular viability , which was reverted by inhibition of autophagycauseda reduction in cellular viability , which was reverted by inhibition of autophagy

alsoleadsalso

alsomight ... contributealso

in decreased toxicityresultingin decreased toxicity

an abnormal build - up of proteinscausesan abnormal build - up of proteins

to a decrease in methylation and an increase in gene expressionshould leadto a decrease in methylation and an increase in gene expression

to a heat - shock response , induction of endoplasmic reticulum chaperones , and thermotoleranceleadsto a heat - shock response , induction of endoplasmic reticulum chaperones , and thermotolerance

an increase in p21causesan increase in p21

large ubiquitin - containing aggregates(passive) caused bylarge ubiquitin - containing aggregates

to the activation of all members of the heat - shock - factor familyleadsto the activation of all members of the heat - shock - factor family

to aggregate formationleadsto aggregate formation

enhanced degradation of p53causesenhanced degradation of p53

the antigen processing and cytotoxic T - cell response and suppress essential immune functions of human CD4 + T cellscould influencethe antigen processing and cytotoxic T - cell response and suppress essential immune functions of human CD4 + T cells

maximal perturbation of the circadian systemcausesmaximal perturbation of the circadian system

activation of thecausesactivation of the

to BLTleadingto BLT

to cell deathleadsto cell death

to autonomic dysfunctionleadingto autonomic dysfunction

thought?ordoes ... causethought?or

significantlycontributessignificantly

to decreased methylationleadsto decreased methylation

a redistribution of CBP and p300 in HEp-2 cellscausesa redistribution of CBP and p300 in HEp-2 cells

the increased membrane excitability(passive) caused bythe increased membrane excitability

opposite effectscausedopposite effects

in accumulation of ubiquitinated proteins , which were shunted into autophagosomes in mouse tumor models and following vaccination improved cross - presentation of short - lived proteins [ 5 , 9 , 11resultedin accumulation of ubiquitinated proteins , which were shunted into autophagosomes in mouse tumor models and following vaccination improved cross - presentation of short - lived proteins [ 5 , 9 , 11

bdnf DNA demethylationcausesbdnf DNA demethylation

alsoresultedalso

to changes in lipoprotein metabolismleadsto changes in lipoprotein metabolism

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Smart Reasoning:

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