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hepatocyte growth factor / scatter factor2(passive) triggered bya receptor tyrosine kinase
insulin receptorsresultingin receptor tyrosine kinase
0007 ] Strategiesresultin agonists of tyrosine kinase receptors
of at least three domains : an extracellular ligand binding domain , a transmembrane domain and a cytoplasmic catalytic domain that can phosphorylate tyrosine residues(passive) are composedReceptor tyrosine kinases
of an extracellular ligand binding domain , a single transmembrane helix , and an intracellular effector domain(passive) are most typically composedReceptor tyrosine kinases
of an extracellular ligand - binding domain Aloe Vera(passive) are composedReceptor tyrosine kinases
a tyr kinase receptorcausesthe tyrosine kinase receptors to dimerize
Another linkleadsfrom the receptor tyrosine kinase
commonly(passive) is ... triggeredTyrosine kinase receptor endocytosis
supportsignaling originatingfrom a receptor tyrosine kinase
KIT(passive) was ... discoveredThe receptor tyrosine kinase
To elucidate the role of receptor … ( More ) Ellen Margrethe Haugsten , Malgorzata Zakrzewska , +4 authorscan influenceJørgen Wesche Endocytosis of tyrosine kinase receptors
as a component of the fusion protein nucleophosmin(passive) was initially discoveredALK ) receptor tyrosine kinase
as an element from the fusion protein nucleophosmin(passive) was discoveredALK ) receptor tyrosine kinase
three different domains : extracellular ( ECD ) , intracellular ( ICD ) and transmembrane [ 4 , 7 , 8(passive) composed bya tyrosine kinase receptor
Activation optioncausesa tyrosine kinase receptor
ubiquitylation of the endocytic machinery(passive) is influenced byTyrosine kinase receptor internalization
three IgG - like domains and an acidic box in the extracellular space , a transmembrane domain and two intracellular tyrosine kinase domains(passive) composed bya tyrosine kinase receptor
Activation of various surface receptors including G protein‐coupled receptors ( GPCRs ) andleadsreceptor tyrosine kinases
processes such as feedback and internalizationmay influencereceptor tyrosine kinase signaling[5 , 6
an effortto discovernovel tyrosine kinase receptors
The junction at the site of the translocationcausesoverexpression of a receptor tyrosine kinase
Activation of G protein - coupled receptors ( GPCRs ) orleadstyrosine kinase receptors
gene mutations(passive) triggered byreceptor tyrosine kinases
that different antidepressants induce LPA1 activationleadingto receptor tyrosine kinase transactivation
first(passive) was ... discoveredThe receptor tyrosine kinase MERTK
Mutations in the binding site forleadsCbl tyrosine kinase receptors
The diversity in the signaling pathways activated by either G protein - coupled receptors ( GPCR ) orresultstyrosine kinase receptors
Tyrosine phosphorylation of GRP78 upon α2 M * binding Binding of growth factors to their cognate cell surface receptorscausestyrosine phosphorylation of the receptors
using drugsinfluencingthe receptors of tyrosine kinase
the downstream responses and finally stimulates cell division.[5triggersthe downstream responses and finally stimulates cell division.[5
the downstream responses and finally stimulates cell division ( 18triggersthe downstream responses and finally stimulates cell division ( 18
multiple signal transduction pathways at once Abnormal functioning of RTKscan triggermultiple signal transduction pathways at once Abnormal functioning of RTKs
multiple signal transduction pathways at once A kinase , alternatively known as a phosphotransferasecan triggermultiple signal transduction pathways at once A kinase , alternatively known as a phosphotransferase
in activation of ARresultingin activation of AR
to signaling from many receptors and participates as a signal transducer in multiple downstream pathways , including regulation of the actin cytoskeletoncontributesto signaling from many receptors and participates as a signal transducer in multiple downstream pathways , including regulation of the actin cytoskeleton
both the duration and the specificity of the signal emittedcan influenceboth the duration and the specificity of the signal emitted
to dimerization and activation by sequential autophosphorylation of specific tyrosine residuesleadsto dimerization and activation by sequential autophosphorylation of specific tyrosine residues
a variety of downstream signaling pathways , such as the RAF / RAS / MAPK cascade that results in phosphorylation of the ER and co - regulatory molecules such as AIB1 / Src-3 [ 12,13,14,15,16,17triggersa variety of downstream signaling pathways , such as the RAF / RAS / MAPK cascade that results in phosphorylation of the ER and co - regulatory molecules such as AIB1 / Src-3 [ 12,13,14,15,16,17
the downstream responses and finally stimulates cell division7triggersthe downstream responses and finally stimulates cell division7
in receptor dimerization / activationresultingin receptor dimerization / activation
different signaling pathways(passive) triggered bydifferent signaling pathways
multiple signal transduction pathways at once Copyright © 2008 Pearson Education , Inc. ... publishing as Pearson Benjamin Cummings Step 1 – signal molecules bind to receptors and a dimer is formedcan triggermultiple signal transduction pathways at once Copyright © 2008 Pearson Education , Inc. ... publishing as Pearson Benjamin Cummings Step 1 – signal molecules bind to receptors and a dimer is formed
in endothelial cell proliferation , migration , and angiogenesis 20resultingin endothelial cell proliferation , migration , and angiogenesis 20
to both survival advantageleadingto both survival advantage
in uncontrolled GIST cell proliferation , invasion , neoangiogenesis , and survivalresultingin uncontrolled GIST cell proliferation , invasion , neoangiogenesis , and survival
to activation of signaling pathways associated with cell growth and survivalleadsto activation of signaling pathways associated with cell growth and survival
to the regulation of cell proliferation , migration , and invasioncontributingto the regulation of cell proliferation , migration , and invasion
to the activation of a number of intracellular signaling pathwaysleadingto the activation of a number of intracellular signaling pathways
the cascade of biochemical events(passive) triggered bythe cascade of biochemical events
to regulate cell proliferation , invasion , migration , angio-discoveredto regulate cell proliferation , invasion , migration , angio-
conformational changes resulting in the endothelial cell proliferationcausingconformational changes resulting in the endothelial cell proliferation
using the Company 's proprietary Humaneered ® technologycreatedusing the Company 's proprietary Humaneered ® technology
to phosphorylation in kinase siteleadingto phosphorylation in kinase site
to its auto‐phosphorylation and activation of multiple downstream signaling networks that can drive cell proliferation , transformation , angiogenesis , invasion and metastasisleadsto its auto‐phosphorylation and activation of multiple downstream signaling networks that can drive cell proliferation , transformation , angiogenesis , invasion and metastasis
to recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation , differentiation , and numerous other biological processesleadingto recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation , differentiation , and numerous other biological processes
to downstream activation of PI3 kinase ( PI3 K ) , AKT , and ultimately mTORleadingto downstream activation of PI3 kinase ( PI3 K ) , AKT , and ultimately mTOR
to the phosphorylation of phosphatidylinositol 3-kinaseleadsto the phosphorylation of phosphatidylinositol 3-kinase
to phosphorylation and activation of Smad2/3leadingto phosphorylation and activation of Smad2/3
in increased phosphorylation on tyrosine residuesresultingin increased phosphorylation on tyrosine residues
the downstream activation of many kinases through various second messenger systems ( Ullrich and Schlessinger , 1990may triggerthe downstream activation of many kinases through various second messenger systems ( Ullrich and Schlessinger , 1990
toward blood vessel formation during angiogenesiscontributetoward blood vessel formation during angiogenesis
cellular proliferation , survival , invasion , and metastasisinfluencescellular proliferation , survival , invasion , and metastasis
to phosphorylation of IRS one and subsequent acti vationleadingto phosphorylation of IRS one and subsequent acti vation
to phosphorylation steps upon binding of its activator VEGFleadingto phosphorylation steps upon binding of its activator VEGF
to angiogenesis , the buildup of new blood vessels around a tumorcontributesto angiogenesis , the buildup of new blood vessels around a tumor
in the auto - phosphorylation of intracellular localized tyrosine residues of the EGFRresultingin the auto - phosphorylation of intracellular localized tyrosine residues of the EGFR
to phosphorylation of downstream molecules when activated through ligand binding [ 8leadingto phosphorylation of downstream molecules when activated through ligand binding [ 8
a complex cascade of events that ends with the cell passing the restriction pointtriggersa complex cascade of events that ends with the cell passing the restriction point
to phosphorylation at residues 239 , 240 ... and 317 within the collagen homologyleadsto phosphorylation at residues 239 , 240 ... and 317 within the collagen homology