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Taiho Pharmaceutical(passive) discovered bytyrosine kinase inhibitor
IC50 's less than 10 & mgr;M. Inactivation of T cellsresultingfrom inhibition of the tyrosine kinase
The compound alpha - methyl - p - tyrosine ( AMPT ) competes with -tyrosine at the tyrosine - binding sitecausinginhibition of tyrosine hydroxylase
from 197,116 compounds in the SPECS database here(passive) were discoveredtyrosine kinase inhibitors
Kyowa Hakko Kirin and approved for the treatment of adult patients with advanced renal cell carcinoma in the European Union plus Norway and Iceland(passive) discovered bytyrosine kinase inhibitor ( TKI
Kyowa Kirin and approved for the treatment of adult patients with advanced renal cell carcinoma ( RCC ) in the European Union plus Norway and Iceland(passive) discovered bytyrosine kinase inhibitor ( TKI
to block different cytokine receptor signaling pathways(passive) are designedTyrosine kinase inhibitors
Kyowa Hakko Kirin and approved for the treatment of adult patients with advanced renal cell carcinoma ( RCC ) in the European Union plus Norway and Iceland(passive) discovered bytyrosine kinase inhibitor ( TKI
Kyowa Kirin and approved for the treatment of adult patients with advanced renal cell carcinoma ( RCC ) in the European Union plus Norway , New Zealand and Iceland(passive) discovered bytyrosine kinase inhibitor ( TKI
Kyowa Hakko Kirin and approved for the treatment of adult patients with advanced renal cell carcinoma ( aRCC ) in the European Union plus Norway and Iceland(passive) discovered bytyrosine kinase inhibitor ( TKI
Kyowa Kirin and approved for the treatment of adult patients with advanced renal cell carcinoma ( RCC ) in the European Union , the United Kingdom , Norway , New Zealand and Iceland(passive) discovered bytyrosine kinase inhibitor ( TKI
to block the action of a specific enzyme called tyrosine kinase(passive) are designedTyrosine kinase inhibitors
to block the BCR - ABL protein(passive) are designedTyrosine kinase inhibitors
Anticancer treatment withcausesthe tyrosine kinase inhibitor sunitinib
to optimize VEGF blockage while minimizing off - target toxicities(passive) was designedtyrosine kinase inhibitor ( TKI
to have effects against different types of cancer(passive) have been discoveredTyrosine kinase inhibitors
TKI ) imatinib(passive) was ... designedThe tyrosine kinase inhibitor
e.g. cetuximab , EMD72000 , or ABX - EGF ) , or intracellular tyrosine kinase inhibitors ( TKI ; e.g. gefitinib or erlotinib).13 Erlotinib is a EGFR tyrosine kinase protein inhibitorpreventingautophosphorylation of tyrosine kinase
to have effective antitumor activities(passive) have been discoveredTyrosine kinase inhibitors
These drugs(passive) were designedTyrosine kinase inhibitors
It was usedto designEGFR Tyrosine Kinase Inhibitors
tyrosine kinases ... downregulationresultsfrom tyrosine kinase inhibition
originally(passive) were ... discoveredTyrosine Kinase inhibitors
5.4 Intensive care medicinepreventsSrc tyrosine kinase inhibition
threonine ( Fig . 2B(passive) caused byaspartate kinase inhibition
inhibition of tyrosine phosphatasecould preventthe effect of inhibition of tyrosine kinase
rapid depletion of the amino acid intracellular poolsprovokemTOR kinase inhibition
Bresulttyrosine kinase inhibitors
their relief of current suppressiondoes ... resultfrom the inhibition of tyrosine kinase activity
Therapy with an epidermal growth factormay contributetyrosine kinase inhibitor
View at Google Scholar V. S. Rodrik - Outmezguine , S. Chandarlapaty , N. C. Pagano et al .causesmTOR kinase inhibition
Current treatment status - Undergoing active treatment Posts on Medivizor Home » Current treatment status - Undergoing active treatmentCan ... influencetyrosine kinase inhibitors
Similarly , non – small cell lung carcinoma ( NSCLC ) exposure to EGFRcan resulttyrosine kinase inhibitors
wif tyrosine at de tyrosine - binding sitecausinginhibition of tyrosine hydroxywase.[2
STI-571 ) selectively and competitively binds KITresultingin inhibition of tyrosine kinase phosphorylation
2 ) the apoptotic phenotyperesultingfrom inhibition of PDGF receptor tyrosine kinase
the abilityto triggera specific tyrosine kinase inhibition
This changecausesinhibition of IRS-1 tyrosine phosphorylation
Example 3 CaMPreventedKinase Inhibition
The relationship between molecular descriptors , drug - likeness parameters and ADMET properties of small moleculescontributedtyrosine kinase inhibitors '
SIRPalpha - induced NO production(passive) was prevented bySIRPalpha - induced NO production
lung injury and death after intravenous LPS in mice R. Scott Stephens , Laura Johnston , Laura Servinsky , Bo S. Kim , Mahendra Damarla Physiological Reports Nov 2015preventslung injury and death after intravenous LPS in mice R. Scott Stephens , Laura Johnston , Laura Servinsky , Bo S. Kim , Mahendra Damarla Physiological Reports Nov 2015
lung injury and death after intravenous LPS in mice ... Johns Hopkins Universitypreventslung injury and death after intravenous LPS in mice ... Johns Hopkins University
any particular effectcausesany particular effect
the upregulation of TNF transcription by LPS in RIPK1 KO macrophagespreventedthe upregulation of TNF transcription by LPS in RIPK1 KO macrophages
pathological microglial phagocytosispreventspathological microglial phagocytosis
feedback - dependent biphasic regulation of AKT signalingcausesfeedback - dependent biphasic regulation of AKT signaling
lung injury and death after intravenous LPS in mice Robert Stephens , Laura Johnston , Laura Servinsky , Bo Soo Kim ... Mahendra Damarlapreventslung injury and death after intravenous LPS in mice Robert Stephens , Laura Johnston , Laura Servinsky , Bo Soo Kim ... Mahendra Damarla
to inhibition of the division and growth of T - cells and some cancer cells activityleadingto inhibition of the division and growth of T - cells and some cancer cells activity
T - cell receptor - mediated signal transduction , ProcpreventsT - cell receptor - mediated signal transduction , Proc
a similar downregulatory effectcauseda similar downregulatory effect
the 3D COL1-mediated induction of BIK.MCF-7 ( A ) andpreventsthe 3D COL1-mediated induction of BIK.MCF-7 ( A ) and
Ang II internalization in MSC and selectively decreased AP Ang II internalization in LLCPK(AT1R ) cells suggesting that AP AT1R in LLCPK(AT1R ) cells and MSC AT1R have similar endocytic phenotypes , and tyrosine kinase activity may play a role in AT1R internalization . " , author = " Becker , { B. N. } and S. Kondo and Jiankang Chen and Harris , { R. C. } " , doi = " 10.3109/10799899909038435preventedAng II internalization in MSC and selectively decreased AP Ang II internalization in LLCPK(AT1R ) cells suggesting that AP AT1R in LLCPK(AT1R ) cells and MSC AT1R have similar endocytic phenotypes , and tyrosine kinase activity may play a role in AT1R internalization . " , author = " Becker , { B. N. } and S. Kondo and Jiankang Chen and Harris , { R. C. } " , doi = " 10.3109/10799899909038435
intracellular calcium release , J. Immunolpreventsintracellular calcium release , J. Immunol
an increased association of alpha - catenin and p120-Cas with E - cadherin(passive) is prevented byan increased association of alpha - catenin and p120-Cas with E - cadherin
an increased association of α - catenin and p120-Cas with E - cadherin(passive) is prevented byan increased association of α - catenin and p120-Cas with E - cadherin
a reduction of STEP61 levels in primary cortical neurons , an effect(passive) was prevented bya reduction of STEP61 levels in primary cortical neurons , an effect
in inhibition of cell growth and cell proliferationmay resultin inhibition of cell growth and cell proliferation
the inhibitory effect of ouabain on prevalence and amplitude of vasomotionpreventedthe inhibitory effect of ouabain on prevalence and amplitude of vasomotion
a strong discerning pressure for cells to acquire resistance to chemotherapy through kinase mutations [ 263triggersa strong discerning pressure for cells to acquire resistance to chemotherapy through kinase mutations [ 263
cell growth inhibition in vitro and reduces lung metastases in vivo | Cancer Research Skip to main content Tumor Biology Abstract 3970causescell growth inhibition in vitro and reduces lung metastases in vivo | Cancer Research Skip to main content Tumor Biology Abstract 3970
necrosome - induced cell death ( Fig . 3c ... and partially prevented the necrosome - associated upregulation of TNFαpreventednecrosome - induced cell death ( Fig . 3c ... and partially prevented the necrosome - associated upregulation of TNFα
pulmonary ischemia - reperfusion - induced acute lung injury Latner Thoracic Surgery Research Laboratories , University Health Network , Toronto General Research Institute , Toronto , ON , Canada Intensive Care Med 38:894 - 905preventspulmonary ischemia - reperfusion - induced acute lung injury Latner Thoracic Surgery Research Laboratories , University Health Network , Toronto General Research Institute , Toronto , ON , Canada Intensive Care Med 38:894 - 905
in reduction and proliferation of the leukemic cellshas resultedin reduction and proliferation of the leukemic cells
pulmonary ischemia - reperfusion - induced acute lung injury Takeshi Oyaizu , Shan - Yu Fung , Atsushi Shiozaki , Zehong Guan , Qiao Zhang , Claudia C dos Santos , Bing Han , Marco Mura , Shaf Keshavjee , Mingyao Liupreventspulmonary ischemia - reperfusion - induced acute lung injury Takeshi Oyaizu , Shan - Yu Fung , Atsushi Shiozaki , Zehong Guan , Qiao Zhang , Claudia C dos Santos , Bing Han , Marco Mura , Shaf Keshavjee , Mingyao Liu
in sustained tumor regression of bladder cancer ... although bladder cancer is important to note that the early use of sunitinib and similar agents in this setting did not have a clinically sustained outcomeresultsin sustained tumor regression of bladder cancer ... although bladder cancer is important to note that the early use of sunitinib and similar agents in this setting did not have a clinically sustained outcome
cell growth inhibition in vitro and reduces lung metastases in vivo Laura D. Nelson , Tiffany N. Lynch , Yanwen Yang , Wei - Lien Wang , Diane Liu , Dafydd G. Thomas and Dennis P. M. Hughes Cancer Res October 1 2014causescell growth inhibition in vitro and reduces lung metastases in vivo Laura D. Nelson , Tiffany N. Lynch , Yanwen Yang , Wei - Lien Wang , Diane Liu , Dafydd G. Thomas and Dennis P. M. Hughes Cancer Res October 1 2014
cell growth inhibition in vitro and reduces lung metastases in vivo Laura D. Nelson , Tiffany N. Lynch , Yanwen Yang , Wei - Lien Wang , Diane Liu , Dafydd G. Thomas and Dennis P. M. Hughes Laura D. Nelson1UT MD Anderson Cancer Center , Houston , TX;Findcausescell growth inhibition in vitro and reduces lung metastases in vivo Laura D. Nelson , Tiffany N. Lynch , Yanwen Yang , Wei - Lien Wang , Diane Liu , Dafydd G. Thomas and Dennis P. M. Hughes Laura D. Nelson1UT MD Anderson Cancer Center , Houston , TX;Find
to increased levels of unphosphorylated Bad which is free to exert its proapoptotic effect either by binding Bcl - xL / Bcl-2 or through its direct actionleadsto increased levels of unphosphorylated Bad which is free to exert its proapoptotic effect either by binding Bcl - xL / Bcl-2 or through its direct action
in a drastic reduction in the amount of H3K9me3 / S10ph modification that was observed by western blotting ( Figure 4Fresultedin a drastic reduction in the amount of H3K9me3 / S10ph modification that was observed by western blotting ( Figure 4F
aberrant angiogenesis in the lungs ... reverses gas exchange abnormalities , and reduces intrapulmonary shunting in the HPS animal modelpreventsaberrant angiogenesis in the lungs ... reverses gas exchange abnormalities , and reduces intrapulmonary shunting in the HPS animal model
in disruption of cellular function including tumor formation and progressionresultingin disruption of cellular function including tumor formation and progression
hypothyroidism in a patient on levothyroxinecausinghypothyroidism in a patient on levothyroxine
and developed by Eisaidiscoveredand developed by Eisai
phosphorylation and activation of these kinases and blocked volume - sensitive activation of NHE1preventedphosphorylation and activation of these kinases and blocked volume - sensitive activation of NHE1
search viagra viagrapreventssearch viagra viagra
in its use as the frontline therapy for chronic myeloid leukemia ( CML ) across the worldhas resultedin its use as the frontline therapy for chronic myeloid leukemia ( CML ) across the world
the activity - dependent modulation of TrkB internalizationpreventsthe activity - dependent modulation of TrkB internalization
internalization of the TCR and therefore increases the number of cell surface TCRs that can bind the tetramer and hence the detection signalpreventsinternalization of the TCR and therefore increases the number of cell surface TCRs that can bind the tetramer and hence the detection signal
dna synthesis and repairpreventsdna synthesis and repair