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4. Point mutationcausestransition mutations of C - G
Point mutationcausestransition mutations of C - G
in other speciesleadsto an increase in transition mutations
these agentscausetransition type of mutation
these mismatchescauseC to T transition mutations
deamination of cytosines(passive) caused byC - to - T transition mutations
these mispairscan causeC to T transition mutations
methyl - cytosinescausesC : T transition mutations
point mutations or small truncations leading to the expression of a gene product that has lost an interaction with another protein(passive) are caused byEdgetic mutations
Unsuccessful repair of the damageoften resultsin transversion or transition mutations
ionizing radiations and toxic substances ... pregnancycan provokegenatic mutations
single - base substitutionsresultingin transition mutations
were foundto causetransition mutations
imp1 andcausecut15 mutations
by deamination(passive) caused byTransition mutations
Deamination agents , for example nitrous acidcan causetransition mutations
for example nitrous acidcan causetransition mutations
The presence of nitrous acidcan causetransition mutations
This lesionresultsin transition mutations
U mismatchescan causetransition mutations
alkylation damagecausestransition mutations
4 ] Deaminating agents , for example nitrous acidcan causetransition mutations
Deaminating agents , for example nitrous acidcan causetransition mutations
alkylation of nucleotidesleadto transition mutations
O6-MeG pairs ambiguously with both C and Tcausingtransition mutations
alkyl groups ... O6 of guanine and O4 of thymidinecan leadto transition mutations
dueto causestransition mutation
guaninecausinga transition mutation
it may mispair with cytosinecausinga transition mutation
an entirely pathological forcecan causemutations ( transitions
by production in eggs(passive) caused byantigenic mutations
MUTATIONS Mistakes in copying DNA Radiation Chemicals in environment ... somethingcan causemutations
Inducing factorscausetransforming mutations
copying errors during dna replication or induced by exposure to external elements such as chemical mutagens , radiation or viruses(passive) can be spontaneously caused byMutations
random errors in dna replication or repair , or by chemical or radiation damage(passive) can be caused byMutations
The free radicals in turn damage large molecules such as proteins and DNA Damage to DNAcausesmutations
random processes or mutation enhancing agents ( like chemicals or radiation(passive) caused bymutations
CpG hypermutability(passive) caused bythe transitional mutations
mistakes during cell division or by exposure to DNA - damaging agents in the environment(passive) may be caused byMutations
radiation , viruses , transposons and mutagenic chemicals , as well as errors that occur during meiosis or DNA replication(passive) are caused byMutations
to a lossleadto a loss
to superior animalsleadsto superior animals
higher mutation frequencies and generates a range of error typescausehigher mutation frequencies and generates a range of error types
in the substitution of serineresultedin the substitution of serine
from the exchange of oneresultfrom the exchange of one
to amino acid ( aa ) changes or formation of a stop codon in PerR , which caused early termination of PerR translationledto amino acid ( aa ) changes or formation of a stop codon in PerR , which caused early termination of PerR translation
to a truncated protein product with negative effectsleadingto a truncated protein product with negative effects
from oxidative DNA damagemay ... resultfrom oxidative DNA damage
to carcinogenesiswill leadto carcinogenesis
to enhanced plant uptake and tolerancecould leadto enhanced plant uptake and tolerance
The glaucoma phenotype seen in this group of patients(passive) caused byThe glaucoma phenotype seen in this group of patients
myeloid disease resembling acute myeloid leukemia in micecausedmyeloid disease resembling acute myeloid leukemia in mice
in free sialic acid - storage diseasesresultingin free sialic acid - storage diseases
to defects in the fusion between autophagosomes and endosomesleadto defects in the fusion between autophagosomes and endosomes
in premature terminations in the plant homolog of Exportin-5 HASTY ( HST ) , known to be important inresultin premature terminations in the plant homolog of Exportin-5 HASTY ( HST ) , known to be important in
to the major signs and symptoms of Shwachman - Diamond syndromeleadto the major signs and symptoms of Shwachman - Diamond syndrome
in premature terminations in the plant homolog of Exportin-5 HASTY ( HSTresultin premature terminations in the plant homolog of Exportin-5 HASTY ( HST
to new genes leading to new functionalityleadingto new genes leading to new functionality
myocilin to accumulate in the cells of the trabecular meshworkcausemyocilin to accumulate in the cells of the trabecular meshwork
to improved fitness and survivalleadingto improved fitness and survival
long QT and Brugada syndromescausinglong QT and Brugada syndromes
the diagnosis of Brugada syndrome(passive) caused bythe diagnosis of Brugada syndrome
to cancer susceptibility ... and germline mutations in this gene may be associated with a cancer predisposition syndrome that does not show microsatellite instabilityleadto cancer susceptibility ... and germline mutations in this gene may be associated with a cancer predisposition syndrome that does not show microsatellite instability
in hematopoietic failureresultin hematopoietic failure
striking alterations in the structure of the male X chromosomealso causestriking alterations in the structure of the male X chromosome
alsocausealso
gain of functioncausinggain of function
to enhanced bone formation in Tricho - Dento - Osseous syndromeleadingto enhanced bone formation in Tricho - Dento - Osseous syndrome
to enhanced bone formation in Tricho - Dento - Osseous syndrome leadingto enhanced bone formation in Tricho - Dento - Osseous syndrome
in a 300 % increase in sodium currentresultedin a 300 % increase in sodium current
AHCcauseAHC
to colorectal cancer susceptibility in Algerian families with suspected Lynch syndromecontributeto colorectal cancer susceptibility in Algerian families with suspected Lynch syndrome
3 M syndrome typecause3 M syndrome type
long QT ( E1784 K ) and Brugada ( R1512W and R1432 G ) syndromescausinglong QT ( E1784 K ) and Brugada ( R1512W and R1432 G ) syndromes
long QT ( E1784 K ) and Brugada ( R1512W and R1432 gcausinglong QT ( E1784 K ) and Brugada ( R1512W and R1432 g
severe mitochondrial translation defectcausesevere mitochondrial translation defect
sALS in a particular geographic populationmay causesALS in a particular geographic population
to a wide spectrum of clinical phenotypes including limb - girdle and scapuloperoneal muscle weaknesses but also late - onset distal myopathymay leadto a wide spectrum of clinical phenotypes including limb - girdle and scapuloperoneal muscle weaknesses but also late - onset distal myopathy
chromosome missegregation and failure in mitosis ... suggesting dis3 promotes cell divisioncausechromosome missegregation and failure in mitosis ... suggesting dis3 promotes cell division