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16 Tautomeric shiftsresultin transition mutations
cytosine deamination(passive) caused bytransition mutations
the deamination of 5-meC(passive) caused bytransition mutations
spontaneous hydrolytic deamination(passive) caused byT transition mutations
If the DNA replication machinery perceives an O6MeG as an adenine homologue , thymine would be paired opposite O6MeGresultingin transition mutations
Deamination of cytosines and 5‐methylcytosinescan leadto C→T transition mutations
The SNP rate for CpG dinucleotides is constant but about ten times higher than other bases because of methyl - mediated deamination of cytosine to uracilcausingtransition mutations
tautomerization between a cytosine form and a thymine formcausestransitional mutations
that cause genetic diseases and cancers through spontaneous deamination of 5-mCresultingin C→T transition mutations
the hypermutability effects of CpG dinucleotide sites and deamination of methylated cytosines(passive) caused bytransition mutations
The mutation takes place in the exon 5causingtransversion and transition mutations
observed substitutions(passive) were caused byTransition mutations
transversion mutations and the othercausedtransition mutations
the targeted nucleotide positions ... more likelyto resultin transition mutations ( A↔G , C↔T
DNA adductscausingtransition mutation
transient tautomersleadto transition mutations
Translesion DNA synthesis across abasic sitescan resultin transition mutations
During SHM , mutations arise from these mismatches through several different mechanismsleadsto transition mutations
the silencing(passive) caused byA transition mutations
Since thymine is not recognized by DNA repair enzymes , cytosine to thymine conversionscan causetransition mutations
This methylated nucleotide pairs with thymine instead of cytosineleadingto GC→AT transition mutations
single - base substitutionsresultingin transition mutations
Modifiers ¶Hydroxylamine ¶ Hydroxylamine Reaction HydroxylamineHydroxylamine ... a chemical mutagencausestransition mutations in DNA
alkyl groups ... O6 of guanine and O4 of thymidinecan leadto transition mutations
the loss of Polη in POLN−/−POLQ−/−(passive) caused byA transition mutations
The presence of nitrous acidcan causetransition mutations
Inosine residues in DNA have been shownto resultin transition mutations
This lesionresultsin transition mutations
EMS mutagenesiscausestransition mutations
O6-MeG pairs ambiguously with both C and Tcausingtransition mutations
PolV after UV induction in E. coli ( 30 , 64(passive) caused bythe transition mutations
the incorporation of RTP into the viral RNAcausestransition mutations ( 8)
in premature terminations in the plant homolog of Exportin 5 HASTY ( HST ) , known to be important in miRNAresultin premature terminations in the plant homolog of Exportin 5 HASTY ( HST ) , known to be important in miRNA
from theTransition mutations result from the exchange of one purine , or pyrimidineresultfrom theTransition mutations result from the exchange of one purine , or pyrimidine
from the substitution of one pyrimidine for another or one purine for anotherresultsfrom the substitution of one pyrimidine for another or one purine for another
higher mutation frequencies and generates a range of error typescausehigher mutation frequencies and generates a range of error types
in a purine - to - purine or pyrimidine - to - pyrimidine changeresultingin a purine - to - purine or pyrimidine - to - pyrimidine change
to a gain of predicted MoRFs , significantly more frequently than control mutations ( marked with an asterisk , and reproduced in Figure 2 of the main textleadto a gain of predicted MoRFs , significantly more frequently than control mutations ( marked with an asterisk , and reproduced in Figure 2 of the main text
to a lossleadto a loss
to the Rifr phenotype occurring spontaneously or after treatment with different mutagensleadingto the Rifr phenotype occurring spontaneously or after treatment with different mutagens
to the gain of predicted α - MoRFs ( Panel B ) significantly more frequently than control mutationsleadto the gain of predicted α - MoRFs ( Panel B ) significantly more frequently than control mutations