Loading ...
DNA methylation , which is knownto resultin gene silencing
DNA methylation [ 34(passive) predominantly caused bygene silencing
DNA Methylation Silencing(passive) Is Caused bySilencing of Genes
DNA methylation and microRNA(passive) caused bygene silencing
DNA methylation pathwayleadingto transcriptional gene silencing
chemically synthesized small interfering RNAs ( siRNAs(passive) triggered by10.1371 / journal.pone.0075443 Gene silencing
because DNA methylation is usually perceivedto causegene silencing
RNA - mediated DNA methylation ,leadingto transcriptional gene silencing
DNA methylation of only promoter CGIscausesgene silencing
can play a role in DNA methylationresultingin transcriptional gene silencing
DNA methylation ... a covalent modificationtriggersheritable gene silencing
Aberrant DNA methylation of PROX1causinggene silencing
epigenetic changes , such as DNA methylation or altered miRNA(passive) is frequently caused byGene silencing
the this protein functions as a demethylase to activate transcription as DNA methylationcausesgene silencing
Expression of such hairpin constructs results in the production of double - stranded RNA ( dsRNAtriggeringposttranscriptional gene silencing
DNA methylation and repressive histone modification ... the most common mechanismscausegene silencing
levels of genic CHG and CHH context DNA methylationcan causegene silencing
CpG / CpNpG islands , which are important sites for DNA methylationmay resultin gene silencing
We are also very interested in proteins and processes that act downstream of DNA methylationto causegene silencing
Epigenetic alterations such as DNA methylation and histone modifications , which are frequent events in tumours [ 76might causesilencing of the CaSR gene
DNA methylation involves the chemical modification of cytosine residues in the genome ,generally resultingin gene “ silencing
self - replicative sense transgenes(passive) triggered bygene silencing
MGMT - promoter methylationcausesgene silencing
DNA methylation , in association with histone modifications and chromatin condensation ... a major epigenetic eventcausesgene silencing
DNA hypermethylation is knownto resultin gene silencing
sense , antisense , or double - stranded RNAcausedgene silencing
CIMP or aberrant DNA methylation Transcription inactivation by DNA hypermethylation at promoter CpG islands of tumor - suppressor genes ,causinggene silencing
B ) Induction of siRNAs at the H06 locus induces local DNA methylationleadingto transcriptional gene silencing
Promoter methylation is generally knownto causegene silencing
FXS ... promoter hypermethylationresultsin gene silencing
RNA - directed DNA methylation ( RdDM ) , first discovered in viroid - infected tobacco ... repressive epigenetic modificationscan triggertranscriptional gene silencing
32 Issue 2 , p1713 DNA methylation , especially in promoter regions of tumor suppressor genes ( GST ... the primary mechanismcausesepigenetic gene silencing
ArticleInfo & Metrics PDF AbstractBACKGROUND AND OBJECTIVES : Aberrant promoter methylation targets CpG islandscausinggene silencing
as a plant defence mechanism(passive) can be triggeredGene silencing
histone acetylation adopting gene expressionhistone deacetylation rambling gene silencinghistone methylation and DNA methylationcausinggene silencing
DNA methylation , particularly of the CG islands within genes ’ promoters or upstream regions , is thoughtto causegene silencing
Epigenetic mechanisms , such as promoter methylationmay causea gene silencing
another decade of R&D ... double - stranded RNAcausesgene silencing
the mechanism by which CpG methylation of the MGMT promoter regioninfluencedsilencing of the gene
With expanded repeat number , the FMR1 gene promoter region undergoes DNA methylation at C residues of CpG dinu - cleotidesresultingin gene silencing
in decreased expression of the PMCA1 proteinresultsin decreased expression of the PMCA1 protein
parthenocarpic fruit development in tomatocausesparthenocarpic fruit development in tomato
in an increase in expression of the gene tissue inhibitor of metalloproteinase-1 ( TIMP-1also resultedin an increase in expression of the gene tissue inhibitor of metalloproteinase-1 ( TIMP-1
gain of virulence in a plant pathogen ( 2013causesgain of virulence in a plant pathogen ( 2013
increased DNA synthesis in moderate hypoxiapreventedincreased DNA synthesis in moderate hypoxia
in recent years to an advanced understanding of the mosquito immune response against infections with bacteria and malaria parasiteshas ledin recent years to an advanced understanding of the mosquito immune response against infections with bacteria and malaria parasites
reactivation of viral production [ 47 , 84to preventreactivation of viral production [ 47 , 84
in C. elegans by short antisense RNAs https://doi.org/10.1126/science.1067534 https://doi.org/10.1101/cshperspect.a003731 https://doi.org/10.1073/pnas.0611282104 https://doi.org/10.1016/j.devcel.2009.03.008 Cell fractionation studies on the guinea pig pancreastriggeredin C. elegans by short antisense RNAs https://doi.org/10.1126/science.1067534 https://doi.org/10.1101/cshperspect.a003731 https://doi.org/10.1073/pnas.0611282104 https://doi.org/10.1016/j.devcel.2009.03.008 Cell fractionation studies on the guinea pig pancreas
to down - regulation of protein expression and functionsleadsto down - regulation of protein expression and functions
gain of virulence in a plant pathogen ... , Nature Communications , 4:1349causesgain of virulence in a plant pathogen ... , Nature Communications , 4:1349
in enhanced intracellular calcium concentrations and increased insulin - induced Akt activationATP2B1 ... resultedin enhanced intracellular calcium concentrations and increased insulin - induced Akt activation
beta - cell death and improve the survival and function of isletswill preventbeta - cell death and improve the survival and function of islets
β - cell death and improve the survival and function of isletswill preventβ - cell death and improve the survival and function of islets
to augmentation of HSP-70 protein expression after heat shockleadsto augmentation of HSP-70 protein expression after heat shock
gain of virulence in a plant pathogen , 4 http://dx.doi.org/10.1038/ncomms2354 Dong , S. , Kong , G. , Qutob , D. , Yu , X. , Tang , J. , Kang , J. , Dai , T. , Wang , H. , Gijzen , M. , Wang , Y. ( 2012causesgain of virulence in a plant pathogen , 4 http://dx.doi.org/10.1038/ncomms2354 Dong , S. , Kong , G. , Qutob , D. , Yu , X. , Tang , J. , Kang , J. , Dai , T. , Wang , H. , Gijzen , M. , Wang , Y. ( 2012
in the suppression of insulin resistance in PA - induced insulin resistance model in Huh7 cellscan resultin the suppression of insulin resistance in PA - induced insulin resistance model in Huh7 cells
suppression by WIN of TRPV1-induced TAK1-JNK1 signalingpreventedsuppression by WIN of TRPV1-induced TAK1-JNK1 signaling
formation of a proteinpreventsformation of a protein
transcription , which will lower the amount of mRNA template that can be translated into a proteinwill preventtranscription , which will lower the amount of mRNA template that can be translated into a protein
cryptic RNA polymerase II transcription of these genespreventscryptic RNA polymerase II transcription of these genes
expression of the cryptic mating loci ( HM ) ( reviewed in Kingston et al . ... 1996preventsexpression of the cryptic mating loci ( HM ) ( reviewed in Kingston et al . ... 1996
in tumor suppressor inactivationresultingin tumor suppressor inactivation
fluorescent signals(passive) caused byfluorescent signals
protein production stemming from the detrimental genepreventsprotein production stemming from the detrimental gene
if the transcript level of the introduced transgenes surpassed a gene - specific thresholdwas triggeredif the transcript level of the introduced transgenes surpassed a gene - specific threshold
in generation of Tol - DC that suppressed T cell responses and selectively promoted Treg generationresultedin generation of Tol - DC that suppressed T cell responses and selectively promoted Treg generation
HIV-1 gp120IIIB - induced degeneration of striatal neuronspreventsHIV-1 gp120IIIB - induced degeneration of striatal neurons
HIV-1 gp120(IIIB)-induced degeneration of striatal neuronspreventsHIV-1 gp120(IIIB)-induced degeneration of striatal neurons
HIV-1 gp120(IIIB)-induced degeneration of striatal neuronsJ NeurovirolYear : 201117414921234828 McMahon J , Huang X , Yang J , Komatsu M , Yue Z , Qian J , et alpreventsHIV-1 gp120(IIIB)-induced degeneration of striatal neuronsJ NeurovirolYear : 201117414921234828 McMahon J , Huang X , Yang J , Komatsu M , Yue Z , Qian J , et al
The disappearance of transcripts(passive) was caused byThe disappearance of transcripts
to genome maintenance and controlling a variety of developmental and physiological processescontributingto genome maintenance and controlling a variety of developmental and physiological processes
in Upregulation of GnRHR and IL23R Expression Normal Colon Cell Lines To identify in vivo relevant target genes of NAV3Resultedin Upregulation of GnRHR and IL23R Expression Normal Colon Cell Lines To identify in vivo relevant target genes of NAV3
in reduced expression of MTA-1 , MPP-2 , MMP-9 and vimentin , and increased expression of TIMP-2 , E - cadherin and collagen 1 at the protein and mRNA levelMYH10 ... resultedin reduced expression of MTA-1 , MPP-2 , MMP-9 and vimentin , and increased expression of TIMP-2 , E - cadherin and collagen 1 at the protein and mRNA level
to the inhibition of migration and invasion of NSCLC cells and a significant decrease in the expression of the invasion - related protein MMP-2ledto the inhibition of migration and invasion of NSCLC cells and a significant decrease in the expression of the invasion - related protein MMP-2
TNF - alpha - mediated insulin resistance in cultured human skeletal musclepreventedTNF - alpha - mediated insulin resistance in cultured human skeletal muscle
from TALE - TET1–induced demethylation and not through simple steric hindrance by binding of the TALE fusion protein itselfresultedfrom TALE - TET1–induced demethylation and not through simple steric hindrance by binding of the TALE fusion protein itself
the TNFSF15-stimulation of up - regulation of miR-29b ( Figure (Figure3D).3Dpreventedthe TNFSF15-stimulation of up - regulation of miR-29b ( Figure (Figure3D).3D
expression strength of the toxic proteins ... Tau[R406W ... or polyQ ... per semight influenceexpression strength of the toxic proteins ... Tau[R406W ... or polyQ ... per se
the TNFSF15-stimulation of up - regulation of miR-29b ( Figure 3Dpreventedthe TNFSF15-stimulation of up - regulation of miR-29b ( Figure 3D
to further genetic instability and dysfunction of the cell cyclemay leadto further genetic instability and dysfunction of the cell cycle