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small regulatory moleculescausepost - transcriptional gene silencing
MicroRNAs ( miRNAs ... small regulatory moleculescausepost - transcriptional gene silencing
Heteroduplex DNA is also a source of small RNAs ( smRNAscausingpost - transcriptional gene silencing
by RNAi(passive) caused bytranscriptional gene silencing signals
resulting in the silencing of diseasecausinggenes ( gene silencing
using siRNAs targeting the promoter / enhancer of a geneto causetranscriptional gene silencing
by promoter hypermethylation(passive) is caused bytranscriptional silencing of the PCDH8 gene
by promoter hypermethylation(passive) is causedtranscriptional silencing of the PCDH8 gene
promoter hypermethylation(passive) is caused bytranscriptional silencing of the PCDH8 gene
usually(passive) is ... causedTranscriptional gene silencing of a transgene
p - shRNAcan causegene silencing , cytotoxicity
CpG island hypermethylationleadsto transcriptional gene silencing
histone H3resultsin transcriptional gene silencing
in plants is required for RNA - directed DNA methylationleadingto transcriptional gene silencing
This epigenetic changecausestranscriptional silencing of the gene
DNA methylationleadsto transcriptional gene silencing
The mechanism by whichcontributesto transcriptional gene silencing
first(passive) was ... discoveredTranscriptional gene silencing
transcriptional repression ... corresponding DNA sequencesleadsto transcriptional gene silencing
integrationresultingin transcriptional gene silencing
this repeated sequencecausesfrataxin gene silencing
Cancers with the CpG island methylator phenotype have frequent DNA hypermethylation in gene promoter regionsoften resultingin gene silencing
embryonic tissuescausingtranscriptional gene silencing
RdDMcan leadto transcriptional gene silencing
by DNA methylation and histone deacetylation [ 46(passive) was influenced byEpigenetic gene silencing
Regulation of chromatin structurecausesgene silencing by lncRNAs
Regulation of chromatin structure Regulation of chromatin structurecausesgene silencing by lncRNAs
sites of repaircan causeepigenetic gene silencing
the primary mechanismcausesepigenetic gene silencing
Methylation at CpG islands in DNA ... an important epigenetic mechanismmay resultin gene silencing
Hypermethylation of CpG islands in the promoter of tumor suppressor genescan resultin gene silencing
CG methylationcausesepigenetic gene silencing*.
CG methylationcausesepigenetic gene silencing
y cleared sites of repaircan causeepigenetic gene silencing
Methylation of cytosine in CpG - rich regions ( i.e. , CpG islands ) located in or near gene promotersresultsin gene silencing
miRNAs act as post - transcriptional regulators that bind to complementary sequences in the three prime untranslated regions ( 3 UTRs ) of target messenger RNA transcripts ( mRNAscan resultin gene silencing
methylation of CpG Island in the promoter regionmay resultin gene silencing
MicroRNAs are post - transcriptional regulators that bind to complementary sequences in the three prime untranslated regions ( 3 ' UTRs ) of target messenger RNA transcripts ( mRNAsusually resultingin gene silencing
Aberrant promoter methylation targets CpG islandscausinggene silencing
the addition of three methyl groups ... target gene promoterscausedgene silencing
for a faster , broader and reliable shRNA deliverydesignedfor a faster , broader and reliable shRNA delivery
to decreased Akt activity in ER - positive MCF-7 cellsledto decreased Akt activity in ER - positive MCF-7 cells
in promoter methylation and consequent inhibition of transcriptionresultsin promoter methylation and consequent inhibition of transcription
a marked inhibition of unstimulated and secretin - stimulated Cl-/HCO3- exchangecauseda marked inhibition of unstimulated and secretin - stimulated Cl-/HCO3- exchange
to tumor initiation , invasion , and metastasiscontributesto tumor initiation , invasion , and metastasis
in a significant reduction of cellular proliferationresultedin a significant reduction of cellular proliferation
the PTPRR downregulation we had observed(passive) was caused bythe PTPRR downregulation we had observed
arrhythmiacausesarrhythmia
in a 60 % decrease in CYP3A4 activity and protein levels with a concomitant 74 % increase in CYP2C9 activityresultedin a 60 % decrease in CYP3A4 activity and protein levels with a concomitant 74 % increase in CYP2C9 activity
in significant reduction in tumor growthresultedin significant reduction in tumor growth
in reduced cell migrationresultedin reduced cell migration
a reduction in the activities of KASII and SAD(passive) caused bya reduction in the activities of KASII and SAD
in enhanced intracellular calcium concentrations and increased insulin - induced Akt activationATP2B1 ... resultedin enhanced intracellular calcium concentrations and increased insulin - induced Akt activation
in decreased expression of the PMCA1 proteinresultsin decreased expression of the PMCA1 protein
cells(passive) caused bycells
to tumor formation and progressioncan contributeto tumor formation and progression
an increased response to LPScausedan increased response to LPS
an increased response to LPS ... in terms of exaggerated production of proinflammatory cytokines which was associated with enhanced TLR signaling and impaired tolerance to LPScausedan increased response to LPS ... in terms of exaggerated production of proinflammatory cytokines which was associated with enhanced TLR signaling and impaired tolerance to LPS
our understanding of developmental biology as well as of cancerinfluencesour understanding of developmental biology as well as of cancer
in dysfunction or diseasecan resultin dysfunction or disease
in significant cell viability inhibition , elevated apoptotic rateresultedin significant cell viability inhibition , elevated apoptotic rate
in a severe hyphal growth defect and reduction in conidiogenesisresultedin a severe hyphal growth defect and reduction in conidiogenesis
in significant cell viability inhibitionresultedin significant cell viability inhibition
in death or acute neurological defectsresultedin death or acute neurological defects
in higher intracellular Ca2 + and simultaneously led to enhanced insulin - induced AKT activityresultedin higher intracellular Ca2 + and simultaneously led to enhanced insulin - induced AKT activity
genes to not expresscan causegenes to not express
in enhanced intracellular calcium concentrationsresultedin enhanced intracellular calcium concentrations
plantto discoverplant
to genome maintenancecontributingto genome maintenance
to tumorigenesiscontributeto tumorigenesis
from regionoriginatingfrom region
from aberrant DNA methylationresultingfrom aberrant DNA methylation
in higher intracellular Ca2resultedin higher intracellular Ca2
in this modelwas ... discoveredin this model
to cancer development and progressioncontributesto cancer development and progression
to greatly increased autophagyledto greatly increased autophagy
in a heritable changedoes ... resultin a heritable change
in increased expression of E - cadherinresultedin increased expression of E - cadherin
to a reduction in total FAK proteinledto a reduction in total FAK protein
in accumulation of pathway intermediates allowing a novel biosynthetic pathway to be proposedresultedin accumulation of pathway intermediates allowing a novel biosynthetic pathway to be proposed