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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

cannabinoids ... an agentpreventsCB1 receptor stimulation

inhibitors of MEK or PI 3-kinase(passive) could be prevented byAMPA receptor stimulation

microbial infections results in IL-6 and other cytokines that block Treg function [ 26(passive) triggered bystrong Toll - like receptor stimulation

that use of formalin deconforms viral epitopes of RSVresultingin poor Toll - like receptor ( TLR ) stimulation

Ang II ) throughtriggersAT1 receptor stimulation

Increased energy demand duringcontributesadrenergic receptor stimulation

2 ) Cardiac & skeletal muscle : Direct stimulation of V - gated Ca2 + channels β1resultsadrenergic receptor stimulation

Expression of Itgb2 which encodes β2 integrincan leadto suppression of Toll - like receptor stimulation

to down - regulation of IRAK-4 protein J Leukoc Biolleadsto down - regulation of IRAK-4 protein J Leukoc Biol

to cardiac hypertrophy in rat neonatal myocytesleadsto cardiac hypertrophy in rat neonatal myocytes

an increase in heart rate and respiratory ratecausesan increase in heart rate and respiratory rate

↵ Yoshikawa H , Tasaka K. Caspase - dependent and -independent apoptosis of mast cells induced by withdrawal of IL-3(passive) is prevented by↵ Yoshikawa H , Tasaka K. Caspase - dependent and -independent apoptosis of mast cells induced by withdrawal of IL-3

to the activation of both innate and adaptive immune responsescan leadto the activation of both innate and adaptive immune responses

dendritic cell maturation and results in the induction of costimulatory molecules and increased antigen - presenting capacitytriggersdendritic cell maturation and results in the induction of costimulatory molecules and increased antigen - presenting capacity

dendritic cell maturation and leads to the induction of costimulatory molecules and elevated antigen - presenting capabilitytriggersdendritic cell maturation and leads to the induction of costimulatory molecules and elevated antigen - presenting capability

the titer of polyreactive antibodies in the circulationprofoundly influencesthe titer of polyreactive antibodies in the circulation

profoundlyinfluencesprofoundly

to additional innate and adaptive immune responsesleadsto additional innate and adaptive immune responses

to increased gene expression of NOD1 and NOD2 in PDL cellsledto increased gene expression of NOD1 and NOD2 in PDL cells

to activation of NF - kB. Tumor necrosis factor alpha - induced proteinleadsto activation of NF - kB. Tumor necrosis factor alpha - induced protein

to the activation of lncRNAs , including lncRNA - Cox2 , PACER , and NEAT1 , which regulate the inflammatory response through specific interactions with cellular proteins ( 15 ⇓leadsto the activation of lncRNAs , including lncRNA - Cox2 , PACER , and NEAT1 , which regulate the inflammatory response through specific interactions with cellular proteins ( 15 ⇓

to activation of NF - kB , which plays a key role in regulating the immune responseleadsto activation of NF - kB , which plays a key role in regulating the immune response

locomotion at this early stagecan triggerlocomotion at this early stage

to the activation of anti - Sm B cells through the B - cell receptor / Toll - like receptor pathwayleadsto the activation of anti - Sm B cells through the B - cell receptor / Toll - like receptor pathway

to up-/down - regulation of various miRNA expressionscan leadto up-/down - regulation of various miRNA expressions

in the expression of a fully functional IL-2Rresultingin the expression of a fully functional IL-2R

to the activation of a pertussis toxin – sensitive G proteinleadsto the activation of a pertussis toxin – sensitive G protein

to down - modulate the inflammation occurred in MS by a positive feedback control of its expressionmay contributeto down - modulate the inflammation occurred in MS by a positive feedback control of its expression

various diseases(passive) caused byvarious diseases

to Th17 cell development within the … ( More ) Glycan recognition at the interface of the intestinal immune system ... target for immune modulation via dietary componentsleadsto Th17 cell development within the … ( More ) Glycan recognition at the interface of the intestinal immune system ... target for immune modulation via dietary components

to impairment of myocyte contractility and activation of several intracellular mediators such as kinases , which are known as critical regulators of myocardial remodellingcan leadto impairment of myocyte contractility and activation of several intracellular mediators such as kinases , which are known as critical regulators of myocardial remodelling

to Th17 cell development within the lungleadsto Th17 cell development within the lung

in cytokine and chemokine release driving persistent T - cell activationresultingin cytokine and chemokine release driving persistent T - cell activation

The expression of chemokine genes by bacteria(passive) to be triggered byThe expression of chemokine genes by bacteria

to NFκB - mediated transcriptionleadsto NFκB - mediated transcription

to innate immune responsescontributesto innate immune responses

to renal arterial vasoconstriction , tubule epithelial sodium reabsorption , augmentation of tubulo – glomerular feedback sensitivity , and inhibition of pressure - natriuresis.77 Converselyleadsto renal arterial vasoconstriction , tubule epithelial sodium reabsorption , augmentation of tubulo – glomerular feedback sensitivity , and inhibition of pressure - natriuresis.77 Conversely

in a loss of SERT activity and reduces platelet 5-HT signalingresultingin a loss of SERT activity and reduces platelet 5-HT signaling

the production of anti - inflammatory mediators of human amniotic epithelial cellsinfluencesthe production of anti - inflammatory mediators of human amniotic epithelial cells

a buildup of intracellular inositol triphosphate and thereby an increase of cytosolic Ca2causesa buildup of intracellular inositol triphosphate and thereby an increase of cytosolic Ca2

tonic clonic convulsionspreventedtonic clonic convulsions

to m - ydriasis , t -achycardia , w - eakness , h - ypertension , and f - asciculationsleadsto m - ydriasis , t -achycardia , w - eakness , h - ypertension , and f - asciculations

to the effects of nicotine in the DBA/2 mouse model of sensory gatingcontributesto the effects of nicotine in the DBA/2 mouse model of sensory gating

corticosteroid - refractory airway neutrophilia and hyperresponsiveness in micecausescorticosteroid - refractory airway neutrophilia and hyperresponsiveness in mice

several cytokines and chemokines in human microglia(passive) caused byseveral cytokines and chemokines in human microglia

Apoptosis of Mast Cells Induced by Withdrawal of IL-3 ... ” European Journal of Immunology , Vol .(passive) Is Prevented byApoptosis of Mast Cells Induced by Withdrawal of IL-3 ... ” European Journal of Immunology , Vol .

a transient burst in Ii – MHC class II biosynthesis , efficient generation of peptide – MHC class II complexes that traffic to the plasma membrane in tubular endosomes and degradation of residual MHC class II present in lysosomesleadsa transient burst in Ii – MHC class II biosynthesis , efficient generation of peptide – MHC class II complexes that traffic to the plasma membrane in tubular endosomes and degradation of residual MHC class II present in lysosomes

bovine adrenal medulla cells in culture(passive) caused bybovine adrenal medulla cells in culture

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Smart Reasoning:

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