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Qaagi - Book of Why

Causes

Effects

a very high O2 affinitycausingsevere tissue hypoxia

cause vascular spasm , blood viscosity increasescausingtissue hypoxia ischemia

COcausesfetal tissue hypoxia

4 affinityleadingto extreme tissue hypoxia

Poisoningcausesfetal tissue hypoxia

that is , repeated acute exposurescausingrepeated tissue hypoxia

decreased tissue oxygen partial pressurepossibly leadingto tissue hypoxia

decreased partial pressure of oxygen in tissuespossibly leadingto tissue hypoxia

tissue oxygen partial pressurepossibly leadingto tissue hypoxia

to decreased oxygen - carrying capacity and the decreased release of oxygen to tissuescausingtissue hypoxia

Various bacterial enzymes and toxins lead to vascular occlusion , ... decreased oxygen ) and ultimately tissue necrosis ( deathresultingin tissue hypoxia

the Various bacterial enzymes and toxins lead to vascular occlusion , ... decreased oxygen ) and ultimately tissue necrosis ( deathresultingin tissue hypoxia

The reduced oxygen - carrying capacity of the bloodleadsto tissue hypoxia

a reduced oxygen - carrying capacity of the bloodresultingin tissue hypoxia

poor gas exchanges in the lungs(passive) caused bytissue oxygenation ( tissue hypoxia )

Capillary loss or drop - out in the retina may lead to reduced oxygen diffusion into the retinal tissuecausingtissue hypoxia

oxygen partial pressurepossibly leadingto tissue hypoxia

An increased kidney oxygen consumptioncausingtissue hypoxia

increased kidney oxygen consumptionresultingin tissue hypoxia

that at the tissue level the hemoglobin will not release oxygen as easilycould resultin tissue hypoxia

by the decreased oxygen - carrying capacity of the reduced red cell mass(passive) caused bytissue hypoxia

This results in decreased tissue perfusion andresultingtissue hypoxia

the oxygen carrying capacity of the bloodcausingtissue hypoxia

adequate oxygenation , ... ( reduced oxygen ) orresultsin tissue hypoxia

It reduces the oxygen - carrying capacity of the bloodleadingto tissue hypoxia

tissue perfusion pressurecausingtissue hypoxia

inadequate oxygen deliveryresultingin tissue hypoxia

The lower tissue perfusion and oxygenation of the bloodleadsto tissue hypoxia

the cerebral perfusion pressure ... in turncausestissue hypoxia

to transfer oxygen to the tissuescausingtissue hypoxia

so increased intrarenal oxygen consumption ... likelyto causetissue hypoxia

Background Reduced retinal vascular oxygen ( O2 ) contentcausestissue hypoxia

This ultimately results in less oxygen being delivered to peripheral tissues and less carbon dioxide being removedcan causetissue hypoxia

Impairment of pulmonary function reduces oxygen intakeresultingin tissue hypoxia

its ability to transport oxygenleadingto tissue hypoxia

cerebral perfusion decreasescausingtissue hypoxia

inadequate tissue perfusionleadingto tissue hypoxia

oxygen for hemoglobinresultsin tissue hypoxia

A reduced cerebral blood flowalso causestissue hypoxia

cerebral perfusion decreases ... , decrease serum pH , and increase in CO2causingtissue hypoxia

to adverse myocardial remodelingto contributeto adverse myocardial remodeling

to increases in permanent tissue damageleadsto increases in permanent tissue damage

hemorrhagic shockcauseshemorrhagic shock

cellular oedema and eventual membrane damage ... for reasons of ion transport mainlywill causecellular oedema and eventual membrane damage ... for reasons of ion transport mainly

from anemiaresultingfrom anemia

symptoms of poisoningthereby causingsymptoms of poisoning

alsomay ... causealso

poisoningto causepoisoning

inflammation , oxidative stress , liver cell injury and increased nuclear transcriptional regulationmay causeinflammation , oxidative stress , liver cell injury and increased nuclear transcriptional regulation

impaired functions of the affected tissuescausingimpaired functions of the affected tissues

to increased capillary permeability and primary brain edemaleadsto increased capillary permeability and primary brain edema

to : a. Metabolic alcalosis d. Convertioncan leadto : a. Metabolic alcalosis d. Convertion

from either decreased oxygen - carrying capacity associated with anemia or decreased oxygen contentresultingfrom either decreased oxygen - carrying capacity associated with anemia or decreased oxygen content

a lessening in the pHcausesa lessening in the pH

to the pathogenesis of insulin resistance likely via increased tissue inflammation ( 45may contributeto the pathogenesis of insulin resistance likely via increased tissue inflammation ( 45

to decreased cellular functionleadsto decreased cellular function

from decreased oxygen availability in the tissuesresultsfrom decreased oxygen availability in the tissues

to local acidification , which is caused by the anaerobic cell metabolism and the lactic acid production associated with itleadsto local acidification , which is caused by the anaerobic cell metabolism and the lactic acid production associated with it

to tissue inflammationcan leadto tissue inflammation

in cellular death and dysfunction of vital organsresultingin cellular death and dysfunction of vital organs

to cellular deathleadingto cellular death

an increased intracellular oxidative stress(passive) may be causedan increased intracellular oxidative stress

to cellular injuryleadingto cellular injury

in increased Epo levelsresultingin increased Epo levels

in an augmentation of the neovascular response in this ROP modelresultingin an augmentation of the neovascular response in this ROP model

anaerobic metabolism , which increases lactate productioncausesanaerobic metabolism , which increases lactate production

to cellular dysfunctionleadsto cellular dysfunction

in cell death ( necrosisresultingin cell death ( necrosis

to the impaired function of the organsleadsto the impaired function of the organs

in proteinuriaresultsin proteinuria

to expression and release of angiogenic factorsleadsto expression and release of angiogenic factors

blood supply , edema and inflammation(passive) caused byblood supply , edema and inflammation

in cellsresultingin cells

to damageleadingto damage

to formation of VEGFleadingto formation of VEGF

to formation of VEGFleadingto formation of VEGF

pulmonary vasoconstriction(passive) caused bypulmonary vasoconstriction

several pathological changes in multiple organscan causeseveral pathological changes in multiple organs

to deathleadsto death

increased lactate(passive) caused byincreased lactate

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Smart Reasoning:

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