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genetic interactionscausingsynthetic lethality in somatic cells
excessive DNA damage(passive) caused bya chemical synthetic lethality
defective HR repair ... sufficientto causesynthetic lethality reviewed by
ATM lossleadsto synthetic lethality in BRCA1
by an inadequate RNR activity(passive) is caused bythe dun1 ixr1 synthetic lethality
an inadequate RNR activity(passive) is caused bythe dun1 ixr1 synthetic lethality
the deletion of both genes was reportedto resultin synthetic lethality
loss of checkpoint function in scaANBS1 mutantswas causingsynthetic lethality
whose mutationledto synthetic lethality
ATM lossleadsto synthetic lethality
multiple genescausingsynthetic lethality
2 Mutationscausedsynthetic lethality
its deletioncausedsynthetic lethality
loss of bothresultedin synthetic lethality
6 ATM lossleadsto synthetic lethality
genesresultsin synthetic lethality
a mutationcausessynthetic lethality
the mutationcausingsynthetic lethality
mutationscausingsynthetic lethality
mutationscausesynthetic lethality
mutationscausedsynthetic lethality
mutationsleadingto synthetic lethality
genetic interactions , including those interactionsresultin synthetic lethality
ATR signaling defectscontributeto synthetic lethality
the lack of SCAANBS1 functioncausessynthetic lethality
2017 ) ATM lossleadsto synthetic lethality
A defect in both repair mechanismsleadsto synthetic lethality
proteinscausesynthetic lethality
Our data ... the lack of SCAANBS1 functioncausessynthetic lethality
Dual inactivation of TDP1 and ATMcausessynthetic lethality
the twocausesynthetic lethality
PARP inhibitionleadsto synthetic lethality
PARP inhibitionwould resultin synthetic lethality
genetic interactionscausingsynthetic lethality
some genetic interactionsresultin synthetic lethality
genetic interactions ... those interactionsresultin synthetic lethality
single agentscausingsynthetic lethality
its absenceleadsto synthetic lethality
a mutantcausessynthetic lethality
the defect in these mutantscausingsynthetic lethality
cellular deathcausescellular death
to cell deathleadsto cell death
combination therapiesto designcombination therapies
a new hope of creating effective , personalized anti - tumor treatmenthas leda new hope of creating effective , personalized anti - tumor treatment
drug targetsto discoverdrug targets
of either a single type of lipid or a mixture of two lipidscomposedof either a single type of lipid or a mixture of two lipids
in studies of fruit fliesoriginatedin studies of fruit flies
to extensive researchleadingto extensive research
of poly(ethylene glycolcomposedof poly(ethylene glycol
using nucleic acidsdesignedusing nucleic acids
such side effects as bloating , headaches , fatigue and weight gaincausesuch side effects as bloating , headaches , fatigue and weight gain
to failwere designedto fail
the current epidemic(passive) caused bythe current epidemic
such side effects as bloating , headaches , fatigue and weight gain , and most recently associated with increasing the risk of cancercausesuch side effects as bloating , headaches , fatigue and weight gain , and most recently associated with increasing the risk of cancer
the damage(passive) caused bythe damage
the crashcausedthe crash
fluid retention and depressioncan also causefluid retention and depression
to the recent financial crisiscontributedto the recent financial crisis
breast cancercausebreast cancer
rapid dose - dependent hypoferremiacausesrapid dose - dependent hypoferremia
like ABACUS 2007-AC1contributedlike ABACUS 2007-AC1
strokecausestroke
alsoresultedalso
to mimic the ECMdesignedto mimic the ECM
to mimic the natural speciesdesignedto mimic the natural species
constriction of arteries and a decrease in HDLcan causeconstriction of arteries and a decrease in HDL
to suppress the immune system and fight against inflammationdesignedto suppress the immune system and fight against inflammation
with extensive regions of substrate interaction designed to optimize the specificity of the interaction between synthetic ribozyme and substratehave been designedwith extensive regions of substrate interaction designed to optimize the specificity of the interaction between synthetic ribozyme and substrate
in the death of the cellresultin the death of the cell
to cell death but no death with either mutation aloneleadsto cell death but no death with either mutation alone
to cell deathleadingto cell death
cell deathcausescell death
cell deathcausescell death
cell death(passive) caused bycell death
cell death ... but a mutation in one of those genes does notcausescell death ... but a mutation in one of those genes does not
in partis causedin part
some mischiefcould causesome mischief
from the combination of mutationsresultsfrom the combination of mutations
to cell death ... 5 , 23leadsto cell death ... 5 , 23
from their nuclease activitiesresultingfrom their nuclease activities