Loading ...
a neurodegenerative disorderresultsfrom mutations in the SMN1 gene ... leading to survival motor neuron ( SMN ) protein deficiency
Infants with SMA type 1 have homozygous gene mutations or deletion of SMN1leadingto a lack of survival motor neuron ( SMN ) protein and the death of motor neurons , which are particularly reliant on it
Mutations in genes that control microtubule regulation and dynamics have been shownto causemotor neuron degeneration in mice and in a form of human motor neuron disease
Loss of myotubularinalso resultedin reduction of MTMR12 protein in C2C12 cells , mice and humans
One prominent example of a neurodegenerative disease featuring RNA dysfunction ... infancyresultsfrom ubiquitous deficiency in the survival motor neuron ( SMN ) protein ( Burghes and Beattie 2009
lower levels of a protein called BDNF , a member of the neurotrophin familyis composedof proteins that regulate the development , function , and survival of neurons
These results together indicateinfluencescell survival and acts as an anti - apoptotic protein in neural cells
a pediatric motor neuron diseaseresultingfrom the loss of the survival motor neuron ( SMN ) protein
Spinal muscular atrophy ( SMA ... the spinal cordresultsfrom the loss of survival motor neuron ( SMN ) protein
The diseaseresultsfrom low levels of the protein encoded by the survival motor neuron ( SMN ) gene
the diseaseresultsthe genetic source of survival motor neuron ( SMN ) protein
that results from mutations in the SMN1 geneleadingto survival motor neuron ( SMN ) protein deficiency
the researchersdesigneda protein to be expressed in neurons of the mouse motor cortex
SMA ... the survival motor neuron 1 ( SMN1 ) geneleadsto a deficiency of the survival motor neuron ( SMN ) protein
expressioncontributesto germ cell / stem cell homeostasis and neural development
motor neuron 1 ( SMN1 ) geneleadsa deficiency of the survival motor neuron ( SMN ) protein
Spinal muscular atrophy ( SMAresultsfrom insufficient levels of the survival motor neuron ( SMN ) protein
neuron 1 ( SMN1 ) generesultsin a deficiency of the survival motor neuron ( SMN ) protein
the survival motor neuron 1 ( SMN1 ) geneleadingto a decrease in the protein , survival motor neuron ( SMN
the survival motor neuron 1 , or SMN1 , geneleadingto a decrease in the survival motor neuron , or SMN protein
endogenous soluble proteinsinfluencingsurvival , development and morphological plasticity of nerve cells ( " neurotrophism
the channels and molecular processescontributeto motor neuron excitability in primary mouse and human iPSC - derived motor neurons
Spinal muscular atrophyresultsfrom the lack of survival motor neuron ( SMN ) protein
The mutationsleadto a deficiency of the survival motor neuron protein
the survival motor neuron 1 ( SMN1 ) geneleadingto a decrease in the survival motor neuron protein
defect in , the survival motor neuron 1 ( SMN1 ) geneleadingto a decrease in the survival motor neuron protein
SMN1 ) geneleadingto a decrease in the survival motor neuron protein
The neuromuscular disease spinal muscular atrophy ( SMA ) is a leading genetic cause of infant mortalityresultingfrom low levels of full - length survival motor neuron ( SMN ) protein
Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy ( SMAresultingfrom low levels of ubiquitously - expressed survival motor neuron ( SMN ) protein
by a genetic defect in the SMN1 gene which codes for SMN(passive) caused bythe survival of motor neuron ( SMN ) protein in snRNP biogenesis
The autosomal recessive neurodegenerative disease spinal muscular atrophy ( SMAresultsfrom low levels of survival motor neuron ( SMN ) protein
Spinal muscular atrophy ( SMA ... deleterious variants in SMN1leadto a marked decrease in survival motor neuron ( SMN ) protein expression
SMA ... a missing or defective SMN1 generesultsin reduced levels of the survival motor neuron ( SMN ) protein
The autosomal recessive neurodegenerative diseaseresultsfrom low levels of survival motor neuron ( SMN ) protein
by mutations in the SMN1 gene(passive) caused bythe survival motor neuron ( SMN ) protein
The diseaseresultsfrom low levels of the protein encoded by the survival motor neuron
This reduction in inflammationresultedin improved neural cell function and survival
by homozygous deletions in the SMN gene(passive) caused bysurvival motor neuron ( SMN ) protein
Higher levels of SMN2 RNAwould leadto high levels of survival motor neuron protein
by mutations in the SMN1 gene(passive) caused bysurvival of motor neurons " ) protein
The disorder(passive) is caused byThe disorder
This disease(passive) is caused byThis disease
The disease(passive) is caused byThe disease
SMA(passive) is caused bySMA
Spinal Muscular Atrophy ( SMA(passive) is caused bySpinal Muscular Atrophy ( SMA
spinal muscular atrophy in model miceto causespinal muscular atrophy in model mice
Spinal muscular atrophy ( SMA(passive) is caused bySpinal muscular atrophy ( SMA
muscular atrophy ( SMA(passive) is caused bymuscular atrophy ( SMA
spinal muscular atrophy in model mice expressing the human centromeric ( SMN2 ) geneto causespinal muscular atrophy in model mice expressing the human centromeric ( SMN2 ) gene
Spinal muscular atrophy(passive) is caused bySpinal muscular atrophy
to a decrease in the survival motorleadingto a decrease in the survival motor
to Spinal Muscular Atrophy ( SMAleadingto Spinal Muscular Atrophy ( SMA
to restoration of nuclear - staining foci ... called gems , which are absent in patients with severe SMAcan leadto restoration of nuclear - staining foci ... called gems , which are absent in patients with severe SMA
The underlying pathology of SMA(passive) is caused byThe underlying pathology of SMA
The underlying pathology of SMA(passive) is caused byThe underlying pathology of SMA
This inherited condition(passive) is caused byThis inherited condition
spinal muscular atrophy ( SMA(passive) is caused byspinal muscular atrophy ( SMA
SMA is known(passive) to be caused bySMA is known
Spinal muscular atrophy ( SMA(passive) is caused bySpinal muscular atrophy ( SMA
to the loss of spinal motor neuronsleadsto the loss of spinal motor neurons
the genetic neuromuscular disorder spinal muscular atrophy ( SMA ) , characterized by spinal cord motoneuron degenerationcausesthe genetic neuromuscular disorder spinal muscular atrophy ( SMA ) , characterized by spinal cord motoneuron degeneration
Spinal muscular atrophy ( SMA(passive) is caused bySpinal muscular atrophy ( SMA
a neuromuscular disease(passive) caused bya neuromuscular disease
The disease(passive) is caused byThe disease
The disease(passive) is caused byThe disease
The neurodegenerative disease spinal muscular atrophy ( SMA(passive) is caused byThe neurodegenerative disease spinal muscular atrophy ( SMA
The human SMN kit(passive) is designedThe human SMN kit
defects in motor axon outgrowth and pathfindingcausesdefects in motor axon outgrowth and pathfinding
SMA(passive) is caused bySMA
SMA(passive) is caused bySMA
to a decrease in the proteinleadingto a decrease in the protein
to pancreas regeneration after targeted T cell removalmay contributeto pancreas regeneration after targeted T cell removal
a neuromuscular disease(passive) caused bya neuromuscular disease
muscles to atrophy over timecausesmuscles to atrophy over time
an inherited neurodegenerative disease(passive) caused byan inherited neurodegenerative disease
all the systemic defects(passive) caused byall the systemic defects
Spinal muscular atrophy ( SMA(passive) is caused bySpinal muscular atrophy ( SMA
a neuromuscular disorder(passive) caused bya neuromuscular disorder
a neuromuscular disorder(passive) caused bya neuromuscular disorder
Spinal muscular atrophy ( SMA ) , the leading genetic disease of children(passive) is caused bySpinal muscular atrophy ( SMA ) , the leading genetic disease of children