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Araki T , Sasaki Y , and Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activationpreventaxonal degeneration
Akari T , Sasaki Y , Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activationpreventaxonal degeneration
MillbrandtJ. Increased nuclear NAD biosynthesis and SIRT1 activationpreventaxonal degeneration
Aug 13;305(5686):1010 - 3.Increased nuclear NAD biosynthesis and SIRT1 activationpreventaxonal degeneration
the retina of the eye ... to helppreventmacula degeneration
All of these could potentially helppreventaxonal degeneration
Lutein and zeaxanthin ... to helppreventmacula degeneration
View at Publisher · View at Google ScholarT. Araki , Y. Sasaki , and J. Milbrandt , “ Increased nuclear NAD biosynthesis and SIRT1 activationpreventaxonal degeneration
Pubmed]The synaptic vesicle protein CSP alphapreventspresynaptic degeneration
B6 , B12 and B9 helppreventmacula degeneration
Eye vitamins Ocuvites ... that helppreventmacula degeneration
R.A. Target - derived neurotrophins coordinate transcription and transport of bclwto preventaxonal degeneration
different experimental paradigms including in vitro Wallerian degeneration , Brain Research , 1030(1(passive) caused byneuritic degeneration
Nov. PMID 26291061 Neurotensin - polyplex - mediated brain - derived neurotrophic factor gene delivery into nigral dopamine neuronspreventsnigrostriatal degeneration
NishimuneL. TabaresF. Schmitz2004The synaptic vesicle protein CSP alphapreventspresynaptic degeneration
Anatomical context of Dnajc5The synaptic vesicle protein CSP alphapreventspresynaptic degeneration
calcification Congenital heart disease(passive) caused byValvular degeneration
Epidermal control of axonal attachment via β - spectrin and the GTPase - activating protein TBC-10 ... Nature Communications ( 2020preventsaxonal degeneration
genetic mutations found in patients with inherited peripheral neuropathy ( IPN(passive) caused byaxonal degeneration
hypoxia , ischaemia or the treatment of hepatocytes with endotoxins or other chemicals [ 10(passive) can be caused byhydropic degeneration
cell death , including programmed apoptosis and nonapoptotic autophagy.[10(passive) is ... caused byIVD degeneration
Valvular Heart Diseasecausingvalvular degeneration
Amyotrophic lateral sclerosis or Lou Gehrig ’s disease ... is thoughtto influenceaxonal degeneration
raised levels of intracellular Ca(2(passive) triggered byaxonal degeneration
the cause is still unclearcausesmacula degeneration
48 ] N. G. Hernandez - Chan , M. J. Bannon , C. E. Orozco - Barrios et al . , " Neurotensin - polyplex - mediated brain - derived neurotrophic factor gene delivery into nigral dopamine neuronspreventsnigrostriatal degeneration
Methamphetamine ... shownto causedopaminergic degeneration
Because hypertension has been shownto causearteriolar degeneration
a variety of primary lesions in the dento - rubro - olivary pathway or Guillain - Mollaret triangle(passive) caused bytransneural degeneration
targeted strategiesto preventaxonal degeneration
the neurological diseasescan causecerebellar degeneration
withdrawal of other trophic support , axotomy or vincristine exposure(passive) caused byaxonal degeneration
This loss of SCG10 ... sufficientto triggeraxonal degeneration
ALS&colon ... sufficientto directly causeaxonal degeneration
both mechanical and toxic insults in ex vivo and in vitro mouse and rat model systems(passive) triggered byaxonal degeneration
the SARM1 protein in nerve cellscan triggeraxonal degeneration
The synaptic vesicle protein CSPαpreventspresynaptic degeneration
The synaptic vesicle protein CSPalphapreventspresynaptic degeneration
GFLV ... several virusescausefanleaf degeneration
have used gene therapy in miceto preventaxonal degeneration
white matter dysfunction in the mouse central nervous system , Nature Medicine ( 2018causeswhite matter dysfunction in the mouse central nervous system , Nature Medicine ( 2018
white matter dysfunction in the mouse central nervous system ” Reprinted from materials provided by USCcauseswhite matter dysfunction in the mouse central nervous system ” Reprinted from materials provided by USC
white matter dysfunction in the mouse central nervous system | Nature Medicine Axel Montagne1causeswhite matter dysfunction in the mouse central nervous system | Nature Medicine Axel Montagne1
a loss in central vision acuitycausesa loss in central vision acuity
white matter dysfunction in the mouse central nervous system Diffuse white - matter disease associated with small - vessel disease and dementia is prevalent in the elderlycauseswhite matter dysfunction in the mouse central nervous system Diffuse white - matter disease associated with small - vessel disease and dementia is prevalent in the elderly
the hyperphosphorylation of the tau protein and redistributing those proteins from the axon to the dendrites , which begins the breakdown of routing and sorting mechanisms.[16causesthe hyperphosphorylation of the tau protein and redistributing those proteins from the axon to the dendrites , which begins the breakdown of routing and sorting mechanisms.[16
nigra and well - defined motor symptoms(passive) caused bynigra and well - defined motor symptoms
to the final diagnosis of SCC ( Figure 2).Figure 2A =leadingto the final diagnosis of SCC ( Figure 2).Figure 2A =
permanent loss of functioncausespermanent loss of function
in blindness ( GAresultingin blindness ( GA
to gradual bilateral decrease in vision starting in early childhood or the teenage yearsleadsto gradual bilateral decrease in vision starting in early childhood or the teenage years
to pain in the spinecan leadto pain in the spine
to coalescence of fluid and cyst formationleadsto coalescence of fluid and cyst formation
The blurry vision(passive) caused byThe blurry vision
ataxia and peripheral neuropathy that resembles Friedreich ataxiacausesataxia and peripheral neuropathy that resembles Friedreich ataxia
neurovascular uncoupling and blood - brain barrier ( BBB ) breakdowncausesneurovascular uncoupling and blood - brain barrier ( BBB ) breakdown
to pigment lossleadingto pigment loss
to vision loss and even complete loss of sight - blindnessleadsto vision loss and even complete loss of sight - blindness
in ataxia , pyramidal signs , peripheral neuropathy and developmental delayresultingin ataxia , pyramidal signs , peripheral neuropathy and developmental delay
the hyperphosphorylation of the tau protein and redistributing those proteins from the axon to the dendrites , which begins the breakdown of routing and sorting mechanisms.[15 ] Cockayne SyndromeEdit Cockayne syndrome results from a mutation in genes that interfere with transcription - coupled repair of nuclear and mitochondrial DNA , replication , and transcriptioncausesthe hyperphosphorylation of the tau protein and redistributing those proteins from the axon to the dendrites , which begins the breakdown of routing and sorting mechanisms.[15 ] Cockayne SyndromeEdit Cockayne syndrome results from a mutation in genes that interfere with transcription - coupled repair of nuclear and mitochondrial DNA , replication , and transcription
to joint space narrowing [ 10 ... that there is a strong association between meniscal damage and cartilage loss [ 9 ] , and that degenerative meniscal tears are positively associated with the severity of articular degeneration compared with other types of meniscal tears [ 14contributesto joint space narrowing [ 10 ... that there is a strong association between meniscal damage and cartilage loss [ 9 ] , and that degenerative meniscal tears are positively associated with the severity of articular degeneration compared with other types of meniscal tears [ 14
to distortion of image and rapid loss of visionleadsto distortion of image and rapid loss of vision
people with moderate and profound vision loss(passive) caused bypeople with moderate and profound vision loss
in hypertrophy of the targeted regionresultingin hypertrophy of the targeted region
This progressive visual loss(passive) was caused byThis progressive visual loss
the visual field losswas causingthe visual field loss
loss of BBB integritycausingloss of BBB integrity
my loss of balance and incoordinationwas causingmy loss of balance and incoordination
from the disintegration of the brain and spinal nervesresultedfrom the disintegration of the brain and spinal nerves
chronic low back pain(passive) caused bychronic low back pain
disease progression and accumulation of disability in multiple sclerosis ( MS ) and other neurodegenerative disorderscausesdisease progression and accumulation of disability in multiple sclerosis ( MS ) and other neurodegenerative disorders
the connections between the brain and muscles to slowly deterioratecausesthe connections between the brain and muscles to slowly deteriorate
ataxia and possibly action or sustention tremorcausesataxia and possibly action or sustention tremor
to the loss of entire spinal tractsleadingto the loss of entire spinal tracts
to joint space narrowing ... that there is a strong association between meniscal damage and cartilage loss , and that degenerative meniscal tears are positively associated with the severity of articular degeneration compared with other types of meniscal tearscontributesto joint space narrowing ... that there is a strong association between meniscal damage and cartilage loss , and that degenerative meniscal tears are positively associated with the severity of articular degeneration compared with other types of meniscal tears
narrowing of disc space , which approximates the vertebral bodies and jams the posterior facets ( Fig . 6.11has causednarrowing of disc space , which approximates the vertebral bodies and jams the posterior facets ( Fig . 6.11
impaired tactile sensation and persistent paincausesimpaired tactile sensation and persistent pain
the ubiquitous ailment of low back paincausesthe ubiquitous ailment of low back pain
to neurovascular uncoupling and limits from a 2.8 kg rectangular air mattress , sourceleadsto neurovascular uncoupling and limits from a 2.8 kg rectangular air mattress , source
chronic pain in peripheral nerves in the hand and legcan causechronic pain in peripheral nerves in the hand and leg