Loading ...

Blob

Smart Reasoning:

C&E

See more*

Qaagi - Book of Why

Causes

Effects

the diseasecausingINF2 mutations

smoking or environmental factors(passive) can be caused bySomatic mutations

indels ( insertions or deletions(passive) are caused byFrameshift mutations

lifestyle and environmental factors(passive) influenced bysomatic mutations

environmental factors , such as exposure to ultraviolet radiation or to certain chemicals(passive) are frequently caused bySomatic mutations

point mutations or small insertions / deletionscausingframeshift mutations

environmental factors , such as cigarette smoke(passive) can sometimes be caused bySomatic mutations

small deletions and insertions(passive) caused byframeshift mutations

a number of different environmental factors(passive) can be caused bySomatic mutations

environmental factors – meaning , not inherited(passive) are ... caused bysomatic mutations

insertions or deletions of a nucleotide(passive) are caused byFrameshift mutations

6 Insertions and deletionscauseframeshift mutations

eithersmall insertions or deletions(passive) caused byframeshift mutations

insertions or deletions of base pairscauseframeshift mutations

The majority of human cancers ... environmental factors and carcinogenic agentsmay leadto somatic mutations

environmental factors such as exposure to ultraviolet radiation , etc(passive) are also caused bySomatic mutations

insertions or deletions of nucleotides and point mutations(passive) caused byframeshift mutations

Insertions , deletions or duplications of a few base pairscauseframeshift mutations

insertions or deletions of a number of nucleotides that are not a multiple of three(passive) caused byframeshift mutations

small insertions and deletions ( indels ) in proteins that are expressed and properly processed by the antigen presentation machinery , culminating in the exposure of tumor neoantigens ( TNAs(passive) caused byframeshift mutations

Carey , exposure to ultraviolet wavelengths in sunlight , or to cancer - causing chemicalscan causesomatic mutations

insertion or deletion of ≥1 nucleic acids in the coding region often resulting in shortened truncated proteins ( frequently found in the MYBPC gene ) , or abnormal splicing of messenger ribonucleic acid ( mRNA(passive) are caused byFrameshift mutations

Non - homologous end joining ( NHEJ ... random insertions or deletionsmay causeframeshift mutations

SSRs(passive) caused byframeshift mutations

when there are insertions , deletions and duplication of the DNA bases in a gene(passive) are also causedFrameshift mutations

single base - pair deletions(passive) caused byframeshift mutations

exon 9 deletions or insertions(passive) caused byframeshift mutations

indels ( 9 isolates(passive) caused byframeshift mutations

orderto preventframeshift mutations

Gene expression ... helppreventsomatic mutations

environmental and life - style factorstriggeringsomatic mutations

Cancer - Specific Biomarkers - Altered protein productsresultingfrom somatic mutations

the identification of messenger RNA ... the Crick , Brenner et al . experiment of 1961discoveredframeshift mutations

reveals three factorsresultingfrom somatic mutations

insertions or deletions in the homopolymer guanosine ( G ) and cytidine ( C ) repeat regions of the UL23 gene(passive) caused byFrameshift mutations

radiation damage to DNA(passive) caused bySomatic mutation

DNA damage and copying errors in the genes of tumour cells(passive) are caused bySomatic mutations

a. A point mutation c. A deletion e. A proofreading mutation C : Insertions and deletionscauseframeshift mutations

experiment of 1961,[27discoveredframeshift mutations

experiment of 1961,[26discoveredframeshift mutations

to tissue mosaicismleadto tissue mosaicism

Most breast cancers(passive) are caused byMost breast cancers

in genetic mosaicism.[1][2][3resultin genetic mosaicism.[1][2][3

All cancers are known(passive) to be caused byAll cancers are known

AbstractAll cancers(passive) are caused byAbstractAll cancers

N All cancers(passive) are caused byN All cancers

UK.All cancers(passive) are caused byUK.All cancers

othersNature2013All cancers(passive) are caused byothersNature2013All cancers

to aging and diseases , such as cancerleadingto aging and diseases , such as cancer

to tumorigenesis or malignant transformationcontributeto tumorigenesis or malignant transformation

to Nrf2 accumulation in cancersleadingto Nrf2 accumulation in cancers

in gains of function in human cancersresultingin gains of function in human cancers

cancer or other diseasescan causecancer or other diseases

26195574 Luks VL , Kamitaki N , Vivero MP , Uller W , Rab R , Bovée JV , Rialon KL , Guevara CJ , Alomari AI , Greene AK , Fishman SJ , Kozakewich HP , Maclellan RA , Mulliken JB , Rahbar R , Spencer SA , Trenor CC 3rd , Upton J , Zurakowski D , Perkins JA , Kirsh A , Bennett JT , Dobyns WB , Kurek KC , Warman ML , McCarroll SA , Murillo R. Lymphatic and other vascular malformative / overgrowth disorders(passive) are caused by26195574 Luks VL , Kamitaki N , Vivero MP , Uller W , Rab R , Bovée JV , Rialon KL , Guevara CJ , Alomari AI , Greene AK , Fishman SJ , Kozakewich HP , Maclellan RA , Mulliken JB , Rahbar R , Spencer SA , Trenor CC 3rd , Upton J , Zurakowski D , Perkins JA , Kirsh A , Bennett JT , Dobyns WB , Kurek KC , Warman ML , McCarroll SA , Murillo R. Lymphatic and other vascular malformative / overgrowth disorders

to complete durable regression in metastatic breast cancer Nikolaos Zacharakisleadingto complete durable regression in metastatic breast cancer Nikolaos Zacharakis

disease , including cancercan causedisease , including cancer

to a range of neurodevelopmental and neurodegenerative diseasescontributeto a range of neurodevelopmental and neurodegenerative diseases

most cases of breast cancercausemost cases of breast cancer

The great majority ( > 95 % ) of human cancers(passive) are caused byThe great majority ( > 95 % ) of human cancers

to genotypic diversity in sterile and fertile populations of the threatened shrub , Grevillea rhizomatosa ( Proteaceae ) 28contributeto genotypic diversity in sterile and fertile populations of the threatened shrub , Grevillea rhizomatosa ( Proteaceae ) 28

to genotypic diversity in sterile and fertile populations of the threatened shrub , Grevillea rhizomatosa ( Proteaceae ) 15contributeto genotypic diversity in sterile and fertile populations of the threatened shrub , Grevillea rhizomatosa ( Proteaceae ) 15

to pituitary tumorigenesisleadto pituitary tumorigenesis

to CaP tumorigenesiscontributeto CaP tumorigenesis

to complete durable regression in metastatic breast cancer | Nature Medicine Nikolaos Zacharakis1leadingto complete durable regression in metastatic breast cancer | Nature Medicine Nikolaos Zacharakis1

to complete durable regression in metastatic breast cancer MEDICINE , RESEARCH & EXPERIMENTAL | TCR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMORleadingto complete durable regression in metastatic breast cancer MEDICINE , RESEARCH & EXPERIMENTAL | TCR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR

to breast cancer ( 78leadingto breast cancer ( 78

to the manifestations of the diseaseleadto the manifestations of the disease

to the pathogenesis of the diseasecontributingto the pathogenesis of the disease

to a disease statemay contributeto a disease state

in mosaicism confined to keratinocytes of the affected arearesultingin mosaicism confined to keratinocytes of the affected area

adult - onset disease , such as cancermay causeadult - onset disease , such as cancer

predisposition to multiple sporadic cancerscausingpredisposition to multiple sporadic cancers

sporadic cancers , one of the three kinds of cancercausessporadic cancers , one of the three kinds of cancer

to cancer developmentcould ... contributeto cancer development

to malignancies such as cancerleadingto malignancies such as cancer

to the development of cancerleadto the development of cancer

endometrial cancercausingendometrial cancer

A majority of cancers ... the likelihood that this will happen increases when we get older(passive) are caused byA majority of cancers ... the likelihood that this will happen increases when we get older

to truncations of its protein in many types of tumors , including breast cancer ( 16–24leadto truncations of its protein in many types of tumors , including breast cancer ( 16–24

cancer , possibly other diseases and agingcausecancer , possibly other diseases and aging

Blob

Smart Reasoning:

C&E

See more*