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insertion or deletion mutations , nonsense mutations , and splice - site mutations(passive) caused byframeshift mutations
frameshift , nonsense , and splice - site mutations(passive) caused byhaploinsufficiency mutations
by frameshift , nonsense , and splice - site mutations(passive) caused byHaploinsufficiency mutations
Insertion , deletion and duplication mutationscauseFRAMESHIFT MUTATIONS
when there are insertions , deletions and duplication of the DNA bases in a gene(passive) are also causedFrameshift mutations
Insertions and deletion of single nucleotidescan causeframeshift mutations
Mutations ) insertion Results in the addition of extra DNA Insertionscan causeframeshift mutations
by small deletion or insertion(passive) caused byframeshift mutations
deletion or insertion and aberrant splicing(passive) caused byframeshift mutations
insertions or deletions of base pairscauseframeshift mutations
an insertion or deletion of a nucleotide causing the reading frame to shift & the protein(passive) are caused byFrameshift mutations
insertions or deletions of nucleotides(passive) are caused byFrameshift mutations
the addition or deletion of nucleotides(passive) are caused byFrameshift mutations
either by the addition of a nucleotide or by a deletion(passive) are causedFrameshift mutations
frameshift , nonsense , and splice - site mutations , which lead to failure to synthesize the products of one COL1A1 allele(passive) caused byhaploinsufficiency mutations
deletion of one or two nucleotides(passive) caused byframeshift mutations
6 Insertions and deletionscauseframeshift mutations
the addition or deletion of bases(passive) are caused byFrameshift mutations
by splicing mutations(passive) caused byframeshift mutations
the addition or loss of a base pair(passive) are caused byFrameshift Mutations
Insertions and deletionscauseframeshift mutations
Insertions and DeletionsDO causeFrameshift mutations
insertions and deletionscan causeframeshift mutations
a deletion(passive) are usually caused byFrameshift mutations
by small deletions , duplications , and insertions(passive) caused byframeshift mutations
Other base changescauseframeshift mutations
by coding region microsatellite(passive) caused byframeshift mutations
Deletionscan also causeframeshift mutations
deletionscausingframeshift mutations
which were predictedto causeframeshift mutations
Indels located in exonscauseframeshift mutations
coding region microsatellite instability(passive) caused byframeshift mutations
DNA polymerase slippagecan causeframeshift mutations
indelscausingframeshift mutations
by indels(passive) caused byFrameshift mutations
Insert between bases in DNAcan causeframeshift mutations
Insert between bases in DNAcan causeframeshift mutations
by duplications and deletions(passive) caused byframeshift mutations
by errors in transcription and splicing of an mRNA(passive) caused byframeshift mutations
by NHEJ(passive) caused byframeshift mutations
to aberrant constitutiveleadto aberrant constitutive
aging phenotypes without affecting reactive oxygen species productioncauseaging phenotypes without affecting reactive oxygen species production
in NSCLCwere discoveredin NSCLC
aging phenotypescauseaging phenotypes
in a cascade of incorrect amino acids and the subsequent proteincould resultin a cascade of incorrect amino acids and the subsequent protein
to a premature end to translation of the mRNAmay leadto a premature end to translation of the mRNA
in early termination of protein translationresultingin early termination of protein translation
to a premature end to translation of the mRNA as well as the can leadto a premature end to translation of the mRNA as well as the
in a premature aging phenotyperesultingin a premature aging phenotype
the production of different amino acidscan causethe production of different amino acids
prematurecausingpremature
to a premature endcan leadto a premature end
a premature endcan causea premature end
to a stop codonleadingto a stop codon
in severe defectsresultin severe defects
in severe genetic diseases such as Tay - Sachs disease.[19may resultin severe genetic diseases such as Tay - Sachs disease.[19
in a gain of fresultingin a gain of f
sporadic LAM(passive) is caused bysporadic LAM
to development of PVleadingto development of PV
to drastic loss of functioncan leadto drastic loss of function
usuallycauseusually
discovering(passive) is caused bydiscovering
in enchondromatosis syndromesresultin enchondromatosis syndromes
in genetic mosaicismresultin genetic mosaicism
in genetic mosaicismresultin genetic mosaicism
EPP after the age of 40causingEPP after the age of 40
the onset of cancerinfluencethe onset of cancer
to NRF2 accumulationleadingto NRF2 accumulation
to the development of age - associated diseasecontributeto the development of age - associated disease
haematopoietic stem cells(passive) caused byhaematopoietic stem cells
to loss of gene or gene product functionleadingto loss of gene or gene product function
to tumor biologycontributeto tumor biology
to the cancer phenotypecontributeto the cancer phenotype
to the constitutive activation of signaling pathways downstream of the affected geneoften leadto the constitutive activation of signaling pathways downstream of the affected gene
Sporadic cancers ( i.e. non - hereditary(passive) are caused bySporadic cancers ( i.e. non - hereditary
cancer in specific tissues ... for examplecan causecancer in specific tissues ... for example
in changes in growth regulation of the affected tissuesresultin changes in growth regulation of the affected tissues
in changes in genotypes and phenotypes , such as malignant mutations giving rise to cancersresultin changes in genotypes and phenotypes , such as malignant mutations giving rise to cancers
to the malfunction ( or death ) of one or more somatic cells ... it is possible for multiple somatic mutations to produce [ [ cancercan leadto the malfunction ( or death ) of one or more somatic cells ... it is possible for multiple somatic mutations to produce [ [ cancer
cancer , aging , and general genome instabilitycan causecancer , aging , and general genome instability