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in the cell line derived from large cell carcinoma of the lung(passive) has been discoveredSomatic Point mutation K122N
any known factorsinfluencingsomatic mutation rate
the factorsinfluencesomatic mtDNA mutations
changes to the chromosome number(passive) are caused byChromosomal mutation
the change in structure and number of chromosomes(passive) is caused byChromosomal mutation
in human cancer(passive) are discoveredsomatic STAT5 mutations
DNA damage and copying errors in the genes of tumour cells(passive) are caused bySomatic mutations
the diseasecausingIVS1 mutation
by mobile genetic elements or errors in DNA repair(passive) caused bySomatic mutations
mobile genetic elements or errors in DNA repair(passive) caused bySomatic mutations
the mechanisms and potential genetic interactionscausesomatic mutations
mitochondrial genes(passive) are sometimes caused bySomatic mutations
We used whole - genome sequencingto discoversomatic mutations
by chemicals(passive) caused bychromosomal mutation
environmental agents ... mutagenscausesomatic mutations
the DNAcausingsomatic mutations
by gene - environment interactions(passive) caused bysomatic mutations
Some environmental exposures like smoking and radiationcan also causesomatic mutations
by different mutational processes(passive) caused bysomatic mutations
DNA damage and deficiency of DNA repair systems ... two major forcesto causesomatic mutations
other drugscauseCHROMOSOMAL MUTATION
well - studied p53 pathway cancerto ... causingsomatic mutations
whole - genome sequencingto discoversomatic mutations
Exposure to exogenous mutagenscan causesomatic mutations
by TP53 gene(passive) caused bysomatic mutations
by environmental factors meaning ... not inherited(passive) are ... caused bysomatic mutations
by environmental factors meaning ... not inherited (passive) are ... caused bysomatic mutations
resequencing protein coding regionsto discoversomatic mutations
by various mutagenic processes(passive) caused bysomatic mutations
cancercausingsomatic mutations
carcinogens like cigarette smoke or UV rays from the sun(passive) can be caused bySomatic mutations
DNA damagecan ... causesomatic mutations
Scientistshave discoveredsomatic mutations
smoking or environmental factors(passive) can be caused bySomatic mutations
the potentialto causesomatic mutations
environmental factorscausingsomatic mutations
environmental factors(passive) can be caused bySomatic mutations
by environmental factors(passive) are ... caused bysomatic mutations
by environmental factors(passive) are ... causedsomatic mutations
no potential mutagencausingsomatic mutations
I major histocompatibility antigen(passive) caused byI major histocompatibility antigen
cancercausescancer
to aberrant constitutiveleadto aberrant constitutive
a defect in negative regulation of TSHcan causea defect in negative regulation of TSH
in MSI - H statusresultsin MSI - H status
to functional damage in critical cell ormay leadto functional damage in critical cell or
to tumor developmentleadingto tumor development
to intrinsic epileptogenicity in pediatric brain tumorscontributesto intrinsic epileptogenicity in pediatric brain tumors
to intrinsic epileptogenicity in pediatric brain tumors)?contributesto intrinsic epileptogenicity in pediatric brain tumors)?
to the development of age - associated diseasecontributeto the development of age - associated disease
port - wine stains(passive) caused byport - wine stains
to loss of gene or gene product functionleadingto loss of gene or gene product function
to the cancer phenotypecontributeto the cancer phenotype
to the constitutive activation of signaling pathways downstream of the affected geneoften leadto the constitutive activation of signaling pathways downstream of the affected gene
Sporadic cancers ( i.e. non - hereditary(passive) are caused bySporadic cancers ( i.e. non - hereditary
cancer in specific tissues ... for examplecan causecancer in specific tissues ... for example
in changes in growth regulation of the affected tissuesresultin changes in growth regulation of the affected tissues
in changes in genotypes and phenotypes , such as malignant mutations giving rise to cancersresultin changes in genotypes and phenotypes , such as malignant mutations giving rise to cancers
cancer , aging , and general genome instabilitycan causecancer , aging , and general genome instability
to the constitutive activation of the pathwayleadingto the constitutive activation of the pathway
activation of oncogenes or loss of function of tumor - suppressor genescausingactivation of oncogenes or loss of function of tumor - suppressor genes
to the development of these disordersleadto the development of these disorders
to chromosome instability in human tumorscould contributeto chromosome instability in human tumors
predisposition to multiple sporadic cancerscausingpredisposition to multiple sporadic cancers
to the pathogenesis of the diseasecontributingto the pathogenesis of the disease
to cancer progression and drug resistanceledto cancer progression and drug resistance
to the development of cancerous tumorscontributeto the development of cancerous tumors
to multiple sporadic cancerscausingto multiple sporadic cancers
human cancerscausinghuman cancers
before tumor initiation in patients of various ageoriginatedbefore tumor initiation in patients of various age
constitutive activation of this processcausingconstitutive activation of this process
in constitutive activation of the BRAF kinaseresultin constitutive activation of the BRAF kinase
to the development of tumorscontributeto the development of tumors
to the development of tumorsleadto the development of tumors
to tumor developmentleadto tumor development
in tumor developmentresultin tumor development
to cancer or other chronic degenerative processes such as agingleadingto cancer or other chronic degenerative processes such as aging
to an increase of kinase activity ofleadingto an increase of kinase activity of
to the diseaseleadto the disease
the diseasecould causethe disease