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Qaagi - Book of Why

Causes

Effects

can lead to many brain problems in late lifecausesmall - vessel disease of the brain

THERAPYcausesCEREBRAL SMALL VESSEL ISCHAEMIC DISEASE

by various mechanisms(passive) caused bycerebral small vessel disease

More diffusecausescerebral small vessel disease

a factorcan resultin small vessel ischemic disease

diabetes mellituscausesdiffuse small - vessel atherosclerotic disease

by a novel heterozygous mutation in HTRA1 3(passive) caused byCerebral small vessel disease

by a novel heterozygous mutation in HTRA1(passive) caused byCerebral small vessel disease

a non - ischaemic mechanism and that any thrombotic vessel lesions occur as secondary end stage pathology(passive) is ... caused bycerebral small vessel disease

small - vessel rubor usuallyaffects the glomeruli(passive) caused bySmall - vessel vasculitisrenal disease

risk factorsinfluencingintracranial small vessel disease

small - vessel redness usuallyaffects the glomeruli(passive) caused bySmall - vessel vasculitisrenal disease

small arteriesleadingto small vessel disease

strokescausedfrom small vessel occlusive disease

by mutations within the Notch3 gene(passive) caused bysmall - vessel disease

the complex mechanismscontributingto small vessel disease

likelydid contributeto the small vessel disease

White matter lesionsresultfrom subcortical small vessel disease

less oxygen ... casescausessmall vessel disease

by smoking and diabetes(passive) caused bysmall vessel disease

your braincan leadto small vessel disease

by diabetes(passive) caused bysmall vessel disease

by diabetes(passive) caused bythe small vessel disease

diabetescausingsmall vessel disease

Diabetescan causesmall vessel disease

a central mechanismleadingto small vessel disease

Smokingcan contributeto small vessel disease

by mutations in the Notch3 gene(passive) caused bysmall - vessel disease

by chronic hypertension(passive) caused bysmall - vessel disease

microscopic brain lesionsresultingfrom small vessel disease

by insufficient blood flow(passive) caused bySmall vessel disease

HT ... not the only oneto causethis small vessel disease

a narrowing of these tiny arteries(passive) is caused bySmall vessel disease

high levels of glucose ( in patients with diabetescan leadto small vessel disease

that high levels of glucose ( in patients with diabetescan leadto small vessel disease

exactly howcausesmall vessel disease

The precise mechanismscontributingto small vessel disease

by mutations in NOTCH3(passive) caused bya small vessel disease

diabetes mellituscausessmall vessel disease

High blood sugar levels in long termscan leadto small - vessel disease

dementia and strokecan causedementia and stroke

to a strokecan leadto a stroke

a variety of cognitive symptomscan causea variety of cognitive symptoms

lacunar stroke and white matter diseasecausinglacunar stroke and white matter disease

lacunar strokecauseslacunar stroke

injuries(passive) caused byinjuries

a quarter of all strokecausesa quarter of all stroke

25 % of all ischaemic strokescauses25 % of all ischaemic strokes

in lacunar infarctsresultingin lacunar infarcts

in lacunar stroke and cardioembolismresultingin lacunar stroke and cardioembolism

to cognitive impairment and dementiacontributesto cognitive impairment and dementia

Some cases(passive) are probably caused bySome cases

to a reduction in white matter which has been shown to be associated with an increased risk of stroke , cognitive dysfunction , dementia and deathimportantly contributesto a reduction in white matter which has been shown to be associated with an increased risk of stroke , cognitive dysfunction , dementia and death

ischemia or infarction of the associated parenchymacausesischemia or infarction of the associated parenchyma

damage to the brain 's white matter ... which can cause memory and cognitive issues over timecausesdamage to the brain 's white matter ... which can cause memory and cognitive issues over time

to memory and thinking problems and ultimately dementialeadsto memory and thinking problems and ultimately dementia

to stroke and vascular dementialeadingto stroke and vascular dementia

damage to the brain s white matter ... responsible for communication among regions ... which can cause memory and cognitive issues over timecausesdamage to the brain s white matter ... responsible for communication among regions ... which can cause memory and cognitive issues over time

to early dementialeadingto early dementia

alsocausesalso

to poor tissue healingleadingto poor tissue healing

stroke(passive) caused bystroke

Vascular dementia(passive) can also be caused byVascular dementia

whitecan also causewhite

to the clinical presentation of ADcontributesto the clinical presentation of AD

in seizures and strokecan resultin seizures and stroke

to local ischemia in the retinaleadsto local ischemia in the retina

dementiacan causedementia

to ease of skin breakdown and poor healing potentialleadingto ease of skin breakdown and poor healing potential

some patients of Syndrome X(passive) could be caused bysome patients of Syndrome X

in subcortical white matter ischemiaresultingin subcortical white matter ischemia

slowly progressive dementia by itselfcan causeslowly progressive dementia by itself

silent damage(passive) was caused bysilent damage

to chronic ischemialeadingto chronic ischemia

strokes(passive) caused bystrokes

to ischemic stroke and vascular dementialeadingto ischemic stroke and vascular dementia

to fatal strokeleadingto fatal stroke

ischemia(passive) caused byischemia

breakdown of the bones in his footcausingbreakdown of the bones in his foot

to damage of the functioning brain cellsleadsto damage of the functioning brain cells

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