in a reduction of ATRA - induced cell cycle arrest at the transition from G1 to S phasecan also resultin a reduction of ATRA - induced cell cycle arrest at the transition from G1 to S phase

in a 65 % or 48 % reduction , respectively ( Fig 1Eresultedin a 65 % or 48 % reduction , respectively ( Fig 1E

to inhibition of mitochondrial complexledto inhibition of mitochondrial complex

the decreased MMP-9 activity(passive) was caused bythe decreased MMP-9 activity

to an enhanced responseledto an enhanced response

in the decreased viability and invasiveness of ATRA - responsive cell linesresultingin the decreased viability and invasiveness of ATRA - responsive cell lines

to a decrease in total and active GTPledto a decrease in total and active GTP

to a strong increase in F - actin bundles along cell edges and some increase in stress fibresledto a strong increase in F - actin bundles along cell edges and some increase in stress fibres

to an approximately 60 % reduction of the corresponding mRNAs ( data not shownledto an approximately 60 % reduction of the corresponding mRNAs ( data not shown

to a G2 / M arrest and proliferation inhibition in HCC827 and SKMES-1 lung cancer cell lines with a EZH2 poly comb protein dependent cyclinB1 and cdc2 regulation mechanismleadsto a G2 / M arrest and proliferation inhibition in HCC827 and SKMES-1 lung cancer cell lines with a EZH2 poly comb protein dependent cyclinB1 and cdc2 regulation mechanism

AKT activation(passive) caused byAKT activation

almost all mitotic defects(passive) caused byalmost all mitotic defects

a considerable downregulation in the expression of CNKSR2 , a CNK homolog , followed by a concomitant de crease from the proliferation of breast cancer cellscauseda considerable downregulation in the expression of CNKSR2 , a CNK homolog , followed by a concomitant de crease from the proliferation of breast cancer cells

to a decrease of CEBPA mRNA expression and to a significant increase in DNA methylationledto a decrease of CEBPA mRNA expression and to a significant increase in DNA methylation

to an acceleration of tumorigenesis and liver colonizationledto an acceleration of tumorigenesis and liver colonization

alsoledalso

in enhanced association of core paraspeckle proteins with NEAT1_2would resultin enhanced association of core paraspeckle proteins with NEAT1_2

to lowered collagen expressionledto lowered collagen expression

to significant dysregulation of ASD risk genes in human neural stem cellsleadsto significant dysregulation of ASD risk genes in human neural stem cells

a marked de crease while in the expression of CNKSR2 which in turn down regulates the proliferation and invasiveness properties of breast cancer cells by means of the PI3 K AKT signaling cascadecauseda marked de crease while in the expression of CNKSR2 which in turn down regulates the proliferation and invasiveness properties of breast cancer cells by means of the PI3 K AKT signaling cascade

retinal degeneration in zebrafishcausesretinal degeneration in zebrafish

in significant reduction of the expression of MIR31HG in HaCaT keratinocytes stimulated with different kinds of cytokines ( IL-17Aresultedin significant reduction of the expression of MIR31HG in HaCaT keratinocytes stimulated with different kinds of cytokines ( IL-17A

the inactivating of Wnt / CTNNB1 signaling pathway(passive) caused bythe inactivating of Wnt / CTNNB1 signaling pathway

in increased levels of TOMM40 , APOE and APOC1 -mRNAsresultedin increased levels of TOMM40 , APOE and APOC1 -mRNAs