to the opposite effectsledto the opposite effects

to cell death and cell - cycle arrest ( Fig . 2Bleadsto cell death and cell - cycle arrest ( Fig . 2B

in a reduction of ATRA - induced cell cycle arrest at the transition from G1 to S phase [ 9can also resultin a reduction of ATRA - induced cell cycle arrest at the transition from G1 to S phase [ 9

to a G2 / M arrest and proliferation inhibition in HCC827 and SKMES-1 lung cancer cell lines with a EZH2 poly comb protein dependent cyclinB1 and cdc2 regulation mechanism [ 17leadsto a G2 / M arrest and proliferation inhibition in HCC827 and SKMES-1 lung cancer cell lines with a EZH2 poly comb protein dependent cyclinB1 and cdc2 regulation mechanism [ 17

to a strong increase in F - actin bundles along cell edges and some increase in stress fibresledto a strong increase in F - actin bundles along cell edges and some increase in stress fibres

multiple mitotic defects that may promote genomic instabilitycausesmultiple mitotic defects that may promote genomic instability

HPA - v and adipogenic defect(passive) caused byHPA - v and adipogenic defect

in derepression of retrotransposonsresultedin derepression of retrotransposons

photoreceptor cell death in adult mouse retinacausedphotoreceptor cell death in adult mouse retina

in prompt myeloma cell death ( data not shownresultedin prompt myeloma cell death ( data not shown

a significant downregulation of cyclin D1 mRNA , which also translated into significant downregulation of cyclin D1 protein ( Fig . 5Bcauseda significant downregulation of cyclin D1 mRNA , which also translated into significant downregulation of cyclin D1 protein ( Fig . 5B

the extrinsic apoptosis pathway in the ectodermtriggeredthe extrinsic apoptosis pathway in the ectoderm

to similar effects with miR-298 overexpression on HCC cell proliferation , cell cycle progression , apoptosis and mobilityledto similar effects with miR-298 overexpression on HCC cell proliferation , cell cycle progression , apoptosis and mobility

to a marked decrease in the cell death rate in cells incubated with erastin ( Figure 3D , histogramledto a marked decrease in the cell death rate in cells incubated with erastin ( Figure 3D , histogram

in downregulated GLUT1 at both mRNA and protein levels ( Figure 3B , P<0.05resultedin downregulated GLUT1 at both mRNA and protein levels ( Figure 3B , P<0.05

to significant inhibition of cell growth , migration and invasionledto significant inhibition of cell growth , migration and invasion

invasiveness and cellular transformation of HBEC-3 cells in vitro EMT enhances tumor cell migration and invasion ( 16causesinvasiveness and cellular transformation of HBEC-3 cells in vitro EMT enhances tumor cell migration and invasion ( 16

to activation of TGFβ signalling and induced expression of a network of genes with functions in extracellular matrix , tumor cell invasion and vitamin D3 metabolismledto activation of TGFβ signalling and induced expression of a network of genes with functions in extracellular matrix , tumor cell invasion and vitamin D3 metabolism

to decreased MDA - MB-231 cell migration and invasion by mechanisms that did not involve the attachment of cells onto extracellular matrix or the regulation of Pak1specifically ledto decreased MDA - MB-231 cell migration and invasion by mechanisms that did not involve the attachment of cells onto extracellular matrix or the regulation of Pak1

shortening of replication tract lengths in unperturbed FANCD2-proficient cells ( 4.58 μm , 78 % of wild type , P < 0.0001 ) or FANCD2-deficient cells ( 4.35 μm , 74 % of FANCD2 deficient , P < 0.0001 ... Figcausedshortening of replication tract lengths in unperturbed FANCD2-proficient cells ( 4.58 μm , 78 % of wild type , P < 0.0001 ) or FANCD2-deficient cells ( 4.35 μm , 74 % of FANCD2 deficient , P < 0.0001 ... Fig

in decreased PTEN mRNA ... and vice versaresultedin decreased PTEN mRNA ... and vice versa

SG dissolution(passive) provoked bySG dissolution

the upregulation of Robo1 expression both at the mRNA and protein levelscausedthe upregulation of Robo1 expression both at the mRNA and protein levels

in a 65 % or 48 % reductionresultedin a 65 % or 48 % reduction

to the downregulation of CCND1 protein and RNA levelsleadsto the downregulation of CCND1 protein and RNA levels

to > 70 % lack of C5orf30 mRNA appearance at 24 and 48 h after treatmentledto > 70 % lack of C5orf30 mRNA appearance at 24 and 48 h after treatment

spontaneous melanization To test this hypothesiscausesspontaneous melanization To test this hypothesis

HRinfluencesHR

to reductions in Smurf2 expression via western blotting analysis ... 58 % , 43 % , and 47 % reduction for sh - S1 , sh - S2 and sh - S3 , respectively ( Figleadsto reductions in Smurf2 expression via western blotting analysis ... 58 % , 43 % , and 47 % reduction for sh - S1 , sh - S2 and sh - S3 , respectively ( Fig

p53 to be phosphorylated on serine 33 , consistent with involvement of the p38 stresscausesp53 to be phosphorylated on serine 33 , consistent with involvement of the p38 stress

a significant reduction in tumour spheroid size ( n = 40 , P = 0.0001 ... in all MPNST cell lines tested ( Figure 3bcauseda significant reduction in tumour spheroid size ( n = 40 , P = 0.0001 ... in all MPNST cell lines tested ( Figure 3b

to reduced cranial cartilage ( arrowheadleadsto reduced cranial cartilage ( arrowhead

to p53-dependent cell cycle arrest and increased cisplatin - induced apoptosisleadsto p53-dependent cell cycle arrest and increased cisplatin - induced apoptosis

in decreased PTEN mRNA and protein abundance ( Figresultedin decreased PTEN mRNA and protein abundance ( Fig

in the decreased viability and invasiveness of ATRA - responsive cell linesresultingin the decreased viability and invasiveness of ATRA - responsive cell lines

to a decrease in survival following treatment with DNA - damaging chemotherapeutics that are used to treat Ewing sarcoma clinicallywould leadto a decrease in survival following treatment with DNA - damaging chemotherapeutics that are used to treat Ewing sarcoma clinically

a marked de creasecauseda marked de crease

to a reduction in mitochondria markers that is PARIS dependentleadsto a reduction in mitochondria markers that is PARIS dependent

in 84 % ( P<0.01 ... whereas a knockdown of ADAM17 diminished sOb - R levels by 23 % ( p   =   0.26 ) compared to the sample transfected with a non - targeting siRNAresultedin 84 % ( P<0.01 ... whereas a knockdown of ADAM17 diminished sOb - R levels by 23 % ( p   =   0.26 ) compared to the sample transfected with a non - targeting siRNA

a considerable downregulation in the expression of CNKSR2 , a CNK homolog , followed by a concomitant de crease from the proliferation of breast cancer cellscauseda considerable downregulation in the expression of CNKSR2 , a CNK homolog , followed by a concomitant de crease from the proliferation of breast cancer cells