to human aging and the formation of tumorscontributesto human aging and the formation of tumors
ER stressthereby causingER stress
to the accumulation of unfolded proteins in the lumenleadingto the accumulation of unfolded proteins in the lumen
to cellular apoptosisleadsto cellular apoptosis
to autoimmunityleadingto autoimmunity
to an unpleasant state ( driveleadsto an unpleasant state ( drive
in cellresultin cell
in chronic inflammationresultingin chronic inflammation
to cell deathleadingto cell death
to activation of all three branches of UPR pathwayleadingto activation of all three branches of UPR pathway
to ER stress responseleadingto ER stress response
to the misfolding of proteinsleadto the misfolding of proteins
to an OA phenotypemay leadto an OA phenotype
for plaque formation and atherosclerosiscontributesfor plaque formation and atherosclerosis
to feeding and metabolic disorders leading to such diseases as obesitycan leadto feeding and metabolic disorders leading to such diseases as obesity
to abnormal fetal developmentleadingto abnormal fetal development
to diseases and loss of life alsoleadingto diseases and loss of life also
in some cytotoxic effectsresultingin some cytotoxic effects
in hyperproliferation and loss of differentiationresultingin hyperproliferation and loss of differentiation
to their established antagonismcontributesto their established antagonism
severe ER stress resulting in accumulation of unfolded proteins in the ER and activation of the UPRcausessevere ER stress resulting in accumulation of unfolded proteins in the ER and activation of the UPR
to hyperplastic clonesleadingto hyperplastic clones
to cellular dysfunction and apoptosiscan leadto cellular dysfunction and apoptosis
to insulin resistance and progression toward various metabolic disorders , including cardiovascular disease , obesity , and type 2 diabetescan ... leadto insulin resistance and progression toward various metabolic disorders , including cardiovascular disease , obesity , and type 2 diabetes
in increased oxidative stressresultingin increased oxidative stress
to insulin resistance and diabetes during chronic treatmentcan ... leadto insulin resistance and diabetes during chronic treatment
in various metabolic complicationsresultingin various metabolic complications
to diseasecan leadto disease
to diseaseleadingto disease
to insulin resistance and diabetes during chroniccan ... leadto insulin resistance and diabetes during chronic
ER - stress and apoptotic cell death [ 19causingER - stress and apoptotic cell death [ 19
to development of contractile failuremay contributeto development of contractile failure
to cell deathleading ultimatelyto cell death
in apoptosismay ... resultin apoptosis
to insulin resistance and diabetescan ... leadto insulin resistance and diabetes
in cardiac dysfunctionresultingin cardiac dysfunction
in the abnormal functionscan resultin the abnormal functions
to insulin resistance and DM during chronic treatmentcan ... leadto insulin resistance and DM during chronic treatment
a reduction in inflammation in inflamed cells , which can cause a headachealso causesa reduction in inflammation in inflamed cells , which can cause a headache