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Qaagi - Book of Why

Causes

Effects

Bisphenol exposurecausesmeiotic aneuploidy

the actin cytoskeleton ... mechanismspreventoocyte aneuploidy

Acquired chromosome missegregationcausinganeuploidy Aneuploidy

both nondisjunction of bivalent chromosomes and predivision of univalent chromosomes(passive) caused byoocyte aneuploidy

chromosome mis - segregation in HKIF4A - depleted MRC-5 cells(passive) caused byQuantitation of aneuploidy

therefore is where small aspirated objects commonly lodgecausing-?-Segmental atelectasis

Alterations in the profile of the hormonal milieu are also suspectedto causeoocyte aneuploidy

maintains the cohesive subpopulation of cohesin in postnatal mouse oocytesto preventoocyte aneuploidy

exogenous agents(passive) caused byoocyte aneuploidy

to early embryonic lossleadsto early embryonic loss

due to defects and delays in the DNA replication and repair mechanismoriginatesdue to defects and delays in the DNA replication and repair mechanism

the zygotic lethality(passive) caused bythe zygotic lethality

subsegmental atelectasis causescausessubsegmental atelectasis causes

to infertilitycan leadto infertility

implantation failure or pregnancy losscan ... causeimplantation failure or pregnancy loss

cancer and genetic instabilitymay causecancer and genetic instability

the increased rate of miscarriage with aging Aneuploidy is responsible for most of the decline in fertility with advancing age ( both with and without IVFcausesthe increased rate of miscarriage with aging Aneuploidy is responsible for most of the decline in fertility with advancing age ( both with and without IVF

changes in gene transcription levels(passive) caused bychanges in gene transcription levels

in miscarriage or severe birth defectsmay resultin miscarriage or severe birth defects

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