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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

Increases stratum corneum hydration and water retention in the short termleading consequentlyto mid to long term improved desquamation and epidermal barrier function of the skin

a single aa substitution in the JAK1 tyrosine kinase that results in hyperactivationthereby leadingto skin serine protease overexpression and disruption of skin barrier function

negative events due to the nature of occlusioncausesstratum corneum hyperhydration and reduces the protective barrier properties of the skin

Sensitised skinleadsto inflammation and reduced skin barrier function

Dehydrationcan leadto dry skin and poor skin barrier function

the lack of whichcausesdry skin and impaired skin barrier function.[67

oilcausesinflammation ... weakens the skin , and disrupts the barrier function in the skin

The inflammationcausesscaling and impairs the stratum corneum barrier and skin functioning

The gene ... the lack of whichcausesdry skin and impaired skin barrier function

the lack of whichcausesdry skin and impaired skin barrier function

the protein filaggrin ... the lack of whichcausesdry skin and impaired skin barrier function

a chronic inflammatory skin diseasecausesdry skin and functional disruption of the skin barrier

Atopic dermatitis ( AD ... a chronic inflammatory skin diseasecan causeskin barrier function damage

constant exposure to urinecan causeskin irritation and compromise skin barrier function

Atopic dermatitis ( AD ... a chronic inflammatory skin diseasecausesdry skin and functional disruption of the skin barrier

Atopic eczema ... a genetic link(10leadsto defective skin barrier and skin breakdown

mutation in the ABCA12 gene , which cause a deficiency of the epidermal lipid transporterresultingin hyperkeratosis and abnormal barrier function of skin

constant exposure to urine , for example in diaperscan causeskin irritation and compromise skin barrier function

which cause a deficiency of the epidermal lipid transporterresultingin hyperkeratosis and abnormal barrier function of skin

The vast majority of affected individuals are due to mutation in the ABCA12 gene , which cause a deficiency of the epidermal lipid transporterresultingin hyperkeratosis and abnormal barrier function of skin

its degradation productsleadto dysfunction of the epidermis and reduced barrier function

This parasitecausesskin lesions and breakdown of epidermal tissue

application of olive oilcausedpoor skin barrier function and increased water loss from the skin

None of the formulationscausederythema or impaired the skin barrier function

Reducing intake of monounsaturated and saturated fats can enhance the anti - inflammatory effects of a diet rich in omega 3s and potentially reduce the amount oleic acid present in the sebumleadingto improved skin barrier function and sebum composition

Sebumcontributesto skin hydration and barrier function

The cutaneous necrosisleadsto widespread epidermal detachment and loss of skin barrier function

The cytokines released by Th2 cells lead to the proliferation and activation of both mast cells and eosinophils in atopic and allergic skin inflammationconsequently leadingto pruritus and impaired skin barrier function

a complex pathogenesis in whichcauseperturbations in the skin barrier and immunological function

psychological stressdoes ... causeskin barrier function to deteriorate

Extracellular matrixinfluencesalveolar epithelial claudin expression and barrier function

dryness(passive) caused bythe weakened skin barrier function

by allergens , such as D. farinae(passive) is causeddestructive skin barrier functions

inhibition of keratinocyte repair processescauseshypotrophy and hypoplasia of the epithelial layer of the skin

by allergens , such as D. farinae ... in AD and thereby an increase of systemic IgE level was suppressed(passive) is caused bydestructive skin barrier functions

itching , irritation ... and in some cases , eczemacan causeitching , irritation ... and in some cases , eczema

to itchy skin at nightcontributeto itchy skin at night

to all sorts of common - day skin issuesleadsto all sorts of common - day skin issues

in pore size reduction and firmer skinresultingin pore size reduction and firmer skin

to dehydrationleadingto dehydration

to increased trans - epidermal water - lossleadsto increased trans - epidermal water - loss

to intense itchingoften leadingto intense itching

to barrier dysfunctionleadingto barrier dysfunction

inflammationcan causeinflammation

to acnecontributeto acne

perforator(passive) caused byperforator

to cancermay leadto cancer

an AD flarecan causean AD flare

more breakouts down the linecausemore breakouts down the line

Current understanding from the medical community shows(passive) is caused byCurrent understanding from the medical community shows

to skin hypersensitivityleadsto skin hypersensitivity

to enhanced water loss and dry skinleadsto enhanced water loss and dry skin

serpiginous vesicular lesionscausingserpiginous vesicular lesions

to hypersensitivityleadsto hypersensitivity

a persistent ulcer , infectionsmay causea persistent ulcer , infections

both congestion and irritationcausesboth congestion and irritation

in making the skin more prone to dehydration , irritation , and infectionresultsin making the skin more prone to dehydration , irritation , and infection

eczemacauseseczema

of lipidsis ... composedof lipids

in scarring of at least some sites of involvementresultsin scarring of at least some sites of involvement

to loss of moistureleadingto loss of moisture

to fluid loss and invasion of pathogenic germscan leadto fluid loss and invasion of pathogenic germs

to atopic dermatitisleadingto atopic dermatitis

serpiginous vesicular lesionscausingserpiginous vesicular lesions

to loss of moisture and increased exposure to irritants and germsleadingto loss of moisture and increased exposure to irritants and germs

dryness(passive) caused bydryness

to improved skin elasticity and firmnessleadingto improved skin elasticity and firmness

to the aggravation of ADleadsto the aggravation of AD

in an increased penetration of the active ingredientsresultingin an increased penetration of the active ingredients

to excessive water lossalso leadsto excessive water loss

Such condition(passive) is caused bySuch condition

These problem(passive) is caused byThese problem

Such situation(passive) is caused bySuch situation

Such issue(passive) is caused bySuch issue

This kind of issue(passive) is caused byThis kind of issue

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Smart Reasoning:

C&E

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