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Abstract : In the search for effective , selective , and nontoxic antiviral and antitumor agents , a variety of strategies have been devisedto designnucleoside analogues
Pharmacistshave createdRiboxin analogues
et lescomposespolycycliques analogues
replacing the central histidine with substituted pyridinium moieties(passive) were designed byTRH ) analogues
ResearchersdesignedPGF2a analogues
to include a N - Acetylglucosamine to help stabilise a β-turn that is a structural feature present in somatostatinâs pharmacophoric region(passive) were designedPeptidomimetic analogues
the loss or depletion of nucleoside kinases(passive) caused bynucleoside analogues
to improve(passive) are designedZanamivir analogues
to be incorporated into viral nucleic acids and act as chain terminators thus inhibiting efficient viral replication(passive) are designedNucleoside analogues
The introduction of a new class of antiglaucoma drugshas resultedthe prostaglandin analogues
Synthesis ofdesigned1,3-diarylpropenone analogues
the hormonal - induced activation of nuclear receptors such as MR and also GR by inducing their degradation via the ubiquitin - proteasome system [ 6 ] , [ 7 ] , [ 8preventthe hormonal - induced activation of nuclear receptors such as MR and also GR by inducing their degradation via the ubiquitin - proteasome system [ 6 ] , [ 7 ] , [ 8
significant conjunctival hyperaemia [ 14 ... and are also potentially proinflammatory [ 11 - 13do causesignificant conjunctival hyperaemia [ 14 ... and are also potentially proinflammatory [ 11 - 13
loss of libido and erectile dysfunctioncauseloss of libido and erectile dysfunction
lid inflammation , irritation , and perhaps even exacerbation of Meibomian gland dysfunctioncould causelid inflammation , irritation , and perhaps even exacerbation of Meibomian gland dysfunction
and synthesized and tested for their anti - epileptic activitywere designedand synthesized and tested for their anti - epileptic activity
bicarbonate secretion and enhance mucosal blood flowcausebicarbonate secretion and enhance mucosal blood flow
and synthesized based on structure - activity relationships and molecular modeling ... 18 , 21 , 22 , 26 , 31 , 34have been designedand synthesized based on structure - activity relationships and molecular modeling ... 18 , 21 , 22 , 26 , 31 , 34
diarrhea , a very troublesome side effect ( Playford et al . , 2001also causediarrhea , a very troublesome side effect ( Playford et al . , 2001
a hormonal thrustcausea hormonal thrust
DNA hypomethylation via inhibition of DNMT1 and can lead to an increase in HbF. Decitabine is FDA approved for the treatment of myeloid malignanciescauseDNA hypomethylation via inhibition of DNMT1 and can lead to an increase in HbF. Decitabine is FDA approved for the treatment of myeloid malignancies
increased eyelash growth(passive) caused byincreased eyelash growth
a testosterone spike in the first few weeks of usagetriggera testosterone spike in the first few weeks of usage
using in silico modelling and subsequently synthesizedwere designedusing in silico modelling and subsequently synthesized
an increase in the whole metabolic activity of PC cellscausean increase in the whole metabolic activity of PC cells
based on the structure of an HDAC6-selective substratedesignedbased on the structure of an HDAC6-selective substrate
goblet cells(passive) caused bygoblet cells
increased pigmentation of the iris and periorbital tissue ( eyelidmay causeincreased pigmentation of the iris and periorbital tissue ( eyelid
fewer side effectswould provokefewer side effects
to the acid environment for h. Pylorimay contributeto the acid environment for h. Pylori
side effects such as eye irritation , itching , eye pain , change of eye colour and darker pigmentation around the eyecan causeside effects such as eye irritation , itching , eye pain , change of eye colour and darker pigmentation around the eye
side effects such as loss of sexual desire , impotence , hot flashes and the development of osteoporosis , which increases the risk of bone fracturescan causeside effects such as loss of sexual desire , impotence , hot flashes and the development of osteoporosis , which increases the risk of bone fractures
in increased uveoscleral outflow andresultsin increased uveoscleral outflow and
unwanted effects akin to lack of sexual desire , impotence , hot flashes and the development of osteoporosis , which increases the risk of bone fracturesmay causeunwanted effects akin to lack of sexual desire , impotence , hot flashes and the development of osteoporosis , which increases the risk of bone fractures
the high fat diet - induced fat expansionpreventthe high fat diet - induced fat expansion
a number of side effects that are dangerous to the eyestriggera number of side effects that are dangerous to the eyes
no cardiovascular or pulmonary side effectscauseno cardiovascular or pulmonary side effects
inflammation and irritation on the eyelidcan causeinflammation and irritation on the eyelid
negative effects similar to lack of sexual desire , impotence , hot flashes and the development of osteoporosis , which increases the risk of bone fracturescan causenegative effects similar to lack of sexual desire , impotence , hot flashes and the development of osteoporosis , which increases the risk of bone fractures
a true inflammation ... even if they cause vessel dilation of the conjunctiva ( hyperemia ) and some stingingcausea true inflammation ... even if they cause vessel dilation of the conjunctiva ( hyperemia ) and some stinging
from the X - ray structure of the natural product in complex with a representative family 18 chitinasedesignedfrom the X - ray structure of the natural product in complex with a representative family 18 chitinase
to side effects like eye irritationcan leadto side effects like eye irritation
thicker , longer and natural looking lashesto createthicker , longer and natural looking lashes
hyperemia and short breakup timecan provokehyperemia and short breakup time
adipocyte differentiation by inhibiting the adipogenic transcriptional program that led to the reduction of lipid accumulation into the cellpreventedadipocyte differentiation by inhibiting the adipogenic transcriptional program that led to the reduction of lipid accumulation into the cell
to increased growth of eyelashescontributeto increased growth of eyelashes
uterine contractionscan causeuterine contractions
side effects such as eye irritation , itching , eye pain , change of eye color and darker pigmentation around the eyecan causeside effects such as eye irritation , itching , eye pain , change of eye color and darker pigmentation around the eye
an increase petropo lis brown pigment of the irismay causean increase petropo lis brown pigment of the iris
significant conjunctival hyperaemia [ 14 Alm A , Grierson I , Shields MBdo causesignificant conjunctival hyperaemia [ 14 Alm A , Grierson I , Shields MB
typicallycausetypically