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Qaagi - Book of Why

Causes

Effects

most commonly(passive) is ... causedPancytopenia due to methotrexate

Concomitant use of PPIs with methotrexate ( primarily at high dose ) may elevate and prolong serum concentrations of methotrexate and/or its metabolite hydroxymethotrexatepossibly leadingto methotrexate toxicities

mutations in the RAS family of genescauseresistance to methotrexate

Concomitant use of methotrexate should be avoided with Omeprazolemay causemethotrexate related toxicities

Concomitant use of methotrexate should be avoided with Rabeprazolemay causemethotrexate related toxicities

Concomitant use of omeprazole with methotrexate ( primarily at high dose ) may elevate and prolong serum concentrations of methotrexate and/or its metabolite hydroxymethotrexatepossibly leadingto methotrexate toxicities

Concomitant use of rabeprazole with methotrexate ( primarily at high dose ) may elevate and prolong serum levels of methotrexate and/or its metabolite hydroxymethotrexatepossibly leadingto methotrexate toxicities

Concomitant use of pantoprazole sodium with methotrexate ( primarily at high dose ) may elevate and prolong serum concentrations of methotrexate and/or its metabolite hydroxymethotrexatepossibly leadingto methotrexate toxicities

to mimic a folate molecule(passive) is designedThe drug methotrexate

prolong serum concentrations of methotrexate and/or its metabolite hydroxymethotrexatepossibly leadingto methotrexate toxicities

serum levels of methotrexate and/or its metabolite hydroxymethotrexatepossibly leadingto methotrexate toxicities

serum levels of methotrexate and/or its metabolitepossibly leadingto methotrexate toxicities

Concurrent use of NEXIUM with methotrexate ... elevated and prolonged levels of methotrexate and its metabolite in the bloodmay leadto methotrexate toxicities

Concurrent use of PRILOSEC with methotrexate ... elevated and prolonged levels of methotrexate and its metabolite in the bloodmay leadto methotrexate toxicities

viagracan ... causepriapism , methotrexate

the waydiscoveredthe joys of methotrexate

Since several factors have been shownto influencethe clearance of methotrexate

its metabolitepossibly leadingto methotrexate toxicities

COMMENTS Malaria Drug Has Utility in RA Hydroxychloroquine less likelyto causehyperlipidemia than methotrexate

Methotrexate in the urinecan causeMethotrexate

by the reduction of tubular secretion of methotrexate(passive) is ... caused bymethotrexate

of these drugs(passive) is composedMethotrexate

methotrexate toxicitycausesmethotrexate

Patientsresultedmethotrexate

the potentialto causemethotrexate

Mgmay causemethotrexate

inhibitors such as lansoprazolemay causemethotrexate

after World War II(passive) was discoveredMethotrexate

my doctorsdiscoveredMethotrexate

1Acausedmethotrexate

in 1947(passive) was discoveredMethotrexate

also(passive) has ... been discoveredMethotrexate

such the lansoprazolemay causemethotrexate

a few days(passive) is caused byMethotrexate

no prescriptioncan causemethotrexate

the nephrotoxicityresultingfrom methotrexate

cells dividing to DNAmay leadmethotrexate

the time hypertension by pancytopenia(passive) is usually caused byMethotrexate

the year viagrawas inventedmethotrexate

proton pump inhibitors such as lansoprazolemay causemethotrexate

severe toxicity when taken in high dosescan causesevere toxicity when taken in high doses

serious birth defectscan causeserious birth defects

folate deficiency(passive) caused byfolate deficiency

floaty and meditationsettingfloaty and meditation

serious liver problemscan causeserious liver problems

undesirable effects such as suppression of the haematopoetic system and gastrointestinal disordersmay causeundesirable effects such as suppression of the haematopoetic system and gastrointestinal disorders

severe toxicity of the liver and bone marrow , which require regular monitoring with blood testingcan causesevere toxicity of the liver and bone marrow , which require regular monitoring with blood testing

to elevated serum levels of the drug and increased toxicityleadingto elevated serum levels of the drug and increased toxicity

embryo - fetal toxicity and fetal death when administered during pregnancycan causeembryo - fetal toxicity and fetal death when administered during pregnancy

embryo - fetal toxicity , including fetal deathcan causeembryo - fetal toxicity , including fetal death

embryo - fetal toxicity and fetal deathcan causeembryo - fetal toxicity and fetal death

to an increase in methotrexate toxicityleadingto an increase in methotrexate toxicity

mouth sores methotrexate side effects cancer methotrexate injectioncausingmouth sores methotrexate side effects cancer methotrexate injection

birth defects and fetal deathhas causedbirth defects and fetal death

severe toxicity of the livermay causesevere toxicity of the liver

in the potential for increased toxicityresultingin the potential for increased toxicity

embryotoxicity , abortion , and fetal defects in humanscausesembryotoxicity , abortion , and fetal defects in humans

embryotoxicity , abortion , and fetal defects in humanscausesembryotoxicity , abortion , and fetal defects in humans

serious or life - threatening side effects on your liver , lungs , kidneys , and bone marrow ( immune systemcan causeserious or life - threatening side effects on your liver , lungs , kidneys , and bone marrow ( immune system

fetal death and congenital abnormalitiescausesfetal death and congenital abnormalities

intrauterine fetal death and/or congenital anomaliescan causeintrauterine fetal death and/or congenital anomalies

to their toxicity , and reduce the action of diuretics ( " water pills " ) by reducing blood flow to the kidneysleadingto their toxicity , and reduce the action of diuretics ( " water pills " ) by reducing blood flow to the kidneys

side effects due to the rapid destruction of cancer cells ( tumor lysis syndromemay causeside effects due to the rapid destruction of cancer cells ( tumor lysis syndrome

side effects due to the rapid destruction of cancer cells ( tumor lysis syndromecausesside effects due to the rapid destruction of cancer cells ( tumor lysis syndrome

serious or life - threatening side effects on your liver , lungs , or kidneyscan causeserious or life - threatening side effects on your liver , lungs , or kidneys

serious or life - threatening side effects on your liver , lungs , or kidneyscan causeserious or life - threatening side effects on your liver , lungs , or kidneys

fetal death , teratogenic effects and miscarriagecan causefetal death , teratogenic effects and miscarriage

side effects due to the with destruction of cancer cells tumor lysis syndromecausesside effects due to the with destruction of cancer cells tumor lysis syndrome

severe or fatal toxicitiescan causesevere or fatal toxicities

miscarriages and birth defects ... as well as liver damagecan causemiscarriages and birth defects ... as well as liver damage

serious or life - threatening side effects on your livercan causeserious or life - threatening side effects on your liver

fetal death or teratogenic effectscan causefetal death or teratogenic effects

serious ( possibly fatal ) side effectshas causedserious ( possibly fatal ) side effects

severe toxicity of the liver , kidneys and bone marrowmay causesevere toxicity of the liver , kidneys and bone marrow

birth defects or death of an unborn childcan causebirth defects or death of an unborn child

birth defects or death of an unborn childcan causebirth defects or death of an unborn child

a very increase in toxicitycausinga very increase in toxicity

hair loss , liver damagecan causehair loss , liver damage

impairment of fertility , oligospermia , and menstrual dysfunctioncan causeimpairment of fertility , oligospermia , and menstrual dysfunction

bone marrow suppression and hepatotoxicitycan causebone marrow suppression and hepatotoxicity

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