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factorsinfluencingplasma protein binding
certain metal ions ( e.g.iron , zinc , lead ) 5 Free - plasma and erythrocyte - bound xenobiotics example :leadbinding to ALAD protein plasma Pb++
an altered albumin distribution produced a greater effect onV than that caused by an altered albumin amount(passive) caused byplasma - protein binding
the breakdown and eventual loss of the cartilage of one or more joints(passive) caused byplasma protein binding
componentsinfluencingplasma protein binding
concomitant drugs ( e.g. , GDC-0449 ) or disease states ( e.g. , increased and varied AAG levels in patients with cancer(passive) caused byplasma protein binding
AG10 , a small moleculepreventsamyloidosis of the plasma protein Transthyretin
salicylates or competitive inhibition of tubular secretion of creatinine by salicylates.33 Kidney Dysfunction(passive) caused byplasma protein binding
concomitant drug ( e.g. , GDC-0449 ) or disease states ( e.g. , ↑AAG level in cancer(passive) caused byplasma protein binding
the negative charges of the nanocomplexescould preventthe nanocomplexes from plasma protein binding
in reduced pharmacologically active unbound drug and reduced insult to myocardial contractility.[6resultingin reduced pharmacologically active unbound drug and reduced insult to myocardial contractility.[6
to part of the difference in the volume of distributionmay contributeto part of the difference in the volume of distribution
the free fraction of drug available to bind to its targetinfluencesthe free fraction of drug available to bind to its target
both the pharmacodynamic effects and the pharmacokinetic properties of peptidescan influenceboth the pharmacodynamic effects and the pharmacokinetic properties of peptides
One characteristic of nonlinear plasma concentration profiles(passive) caused byOne characteristic of nonlinear plasma concentration profiles
its pharmacokinetic parameters depending on the doseinfluencesits pharmacokinetic parameters depending on the dose
displacement interactionscan causedisplacement interactions
The stereoselectivity in brain distribution indicated by the partition coefficient Kp ( total AUC ratio brain to plasma(passive) was caused byThe stereoselectivity in brain distribution indicated by the partition coefficient Kp ( total AUC ratio brain to plasma
in detectable levels of oligonucleotide in the urine ( Crooke , 1998resultedin detectable levels of oligonucleotide in the urine ( Crooke , 1998