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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

the recent trendsinfluencingthe Plasma Protein Binding Assay Market

In order to achieve high unbound plasma drug concentration , it seems obviousto designcompounds with low plasma protein binding

This disruptionresultsin accumulation of different plasma proteins

mature plasma cellsleadingto an overproduction of plasma cell proteins ( immunoglobulins

Factors ... free drug concentrationinfluencedrug binding to plasma proteins

Long - term use of prednisolonecausesdeficiency of proteins in blood plasma

Factorsinfluencingplasma protein binding , such as acidosis

hemorrhage(passive) can be caused byPlasma protein loss

knownto causenon - enzymatic glycation of plasma proteins

36 Plasma proteinwill causebinding Extensive plasma protein binding

Iron deficiencyleadsto low plasma bound protein

the formation of immune complexes , which are hypothesizedto causeenhanced glomerular permeability to plasma proteins

7 Medicinal chemistry optimization of WM-8014designedto reduce plasma - protein binding

knownto influenceMPA plasma protein binding

the situationscausedaltered plasma protein binding

A quantitative trait locusinfluencingfree plasma protein

the relationship between total and free MPA pharmacokinetics ... knownto influenceMPA plasma protein binding

likely ... the free concentrations of drugsto influenceplasma protein binding and

Factorsinfluencingplasma protein binding

componentsinfluencingplasma protein binding

Ruscus extractinfluencesthe passage of plasma protein in the interstitium

1 mg of 2.5 mg per day or higherresultedin plasma protein binding

doses of 2.5 mg per day or higherresultedin plasma protein binding

30 mg doses of 2.5 mg per day or higherresultedin plasma protein binding

mg / ml doses of 2.5 mg per day or higherresultedin plasma protein binding

of two identical molecular halves each consisting of three non - identical A alpha- , B beta- and gamma - chain subunits held together by multiple disulfide bonds(passive) is composedFibrinogen , a 340-kDa plasma protein

70 mg uses doses of 2.5 mg per day or higherresultedin plasma protein binding

side effects of 2.5 mg per day or higherresultedin plasma protein binding

muscular doses of 2.5 mg per day or higherresultedin plasma protein binding

500 mg doses of 2.5 mg per day or higherresultedin plasma protein binding

Studies administering fibroblast growth factor 8 assay doses of 2.5 mg per day or higherresultedin plasma protein binding

hyperglycemiacausingnonenzymatic glycation of plasma proteins

orange pill of 2.5 mg per day or higherresultedin plasma protein binding

Substance Pcausesplasma protein extravasation

the thermospheric windcausesplasma distribution in the topside ionosphere

Studies administering how much does methotrexate pill cost doses of 2.5 mg per day or higherresultedin plasma protein binding

Physicalcausesmild in plasma proteins

capillary permeabilitycausingextravasation of plasma proteins

a capillary leak syndromeresultingfrom extravasation of plasma proteins

Damage to the alveolar wallscausesextravasation of plasma proteins

to the increase of the concentration of binding drugwould contributeto the increase of the concentration of binding drug

significant medical helpcausingsignificant medical help

in an increased background activity in micro PET imagesresultsin an increased background activity in micro PET images

to the metabolite contributing a greater share to the efficacycontributesto the metabolite contributing a greater share to the efficacy

the distribution , clearance , and efficacy of a drugmay significantly influencethe distribution , clearance , and efficacy of a drug

efficacy , distribution and eliminationcan influenceefficacy , distribution and elimination

the compounds to have reduced distribution in the plasmamay causethe compounds to have reduced distribution in the plasma

very low brain uptake(passive) caused byvery low brain uptake

Drug effectiveness(passive) might be influenced byDrug effectiveness

This syndrome(passive) is caused byThis syndrome

to swift excretionleadingto swift excretion

alsoinfluencesalso

mGluR1s(passive) was ... caused bymGluR1s

in increased plasma clearanceresultedin increased plasma clearance

the pharmacokinetic and pharmacodynamic properties of a druginfluencesthe pharmacokinetic and pharmacodynamic properties of a drug

to increase in freeleadto increase in free

to the violence of growth and sexual development of children and adolescentsleadsto the violence of growth and sexual development of children and adolescents

renal clearancecan influencerenal clearance

more drug to stay in thewill causemore drug to stay in the

alsoinfluencesalso

alsoinfluencesalso

your resultsinfluencingyour results

One characteristic of nonlinear plasma concentration profiles(passive) caused byOne characteristic of nonlinear plasma concentration profiles

nonlinear plasma concentration profiles(passive) caused bynonlinear plasma concentration profiles

not only urate deposition but also the renal excretion of uric acidmay influencenot only urate deposition but also the renal excretion of uric acid

the entry of drugs into the central nervous compartmentsinfluencesthe entry of drugs into the central nervous compartments

to an increase in free levels of these substancesleadsto an increase in free levels of these substances

to a higher free fraction of the drugleadingto a higher free fraction of the drug

in reduced pharmacologically active unbound drug and reduced insult to myocardial contractilityresultingin reduced pharmacologically active unbound drug and reduced insult to myocardial contractility

The stereoselective brain distribution indicated by the K(p ) of 0.22 and 0.04 for S- and R - CZE(passive) respectively ... was caused byThe stereoselective brain distribution indicated by the K(p ) of 0.22 and 0.04 for S- and R - CZE

The stereoselective brain distribution indicated by the K(p ) of 0.22 and 0.04 for S- and R - CZE , respectively(passive) was caused byThe stereoselective brain distribution indicated by the K(p ) of 0.22 and 0.04 for S- and R - CZE , respectively

displacement interactions More than one drug can bind to the same site on albumincan causedisplacement interactions More than one drug can bind to the same site on albumin

betterpromptingbetter

side effectscausingside effects

displacement interactionscan causedisplacement interactions

alsoinfluencesalso

to maximal plasma - free concentrations that are insufficient to inhibit OAT1leadsto maximal plasma - free concentrations that are insufficient to inhibit OAT1

unproductive loss of CO to blood haemoglobinwould causeunproductive loss of CO to blood haemoglobin

to failure of the devicecan leadto failure of the device

to increased levels of free concentrations of drugsleadingto increased levels of free concentrations of drugs

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Smart Reasoning:

C&E

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