in reduced pharmacologically active unbound drug and reduced insult to myocardial contractility.[6resultingin reduced pharmacologically active unbound drug and reduced insult to myocardial contractility.[6

in a > 100 fold shift in activity in a functional GTPγS assay run in tandem in the presence and absence of human serum albuminresultingin a > 100 fold shift in activity in a functional GTPγS assay run in tandem in the presence and absence of human serum albumin

in increased free methotrexate concentrations Cyclosporineresultingin increased free methotrexate concentrations Cyclosporine

19;322(1):131 - 4.Brain uptake of a food dye , erythrosin B(passive) prevented by19;322(1):131 - 4.Brain uptake of a food dye , erythrosin B

in more free drug available for metabolism through the liverresultingin more free drug available for metabolism through the liver

the activation of lymphocyte populations of Peyer 's patches and mesenteric lymph nodes , which is known as organizedpreventsthe activation of lymphocyte populations of Peyer 's patches and mesenteric lymph nodes , which is known as organized

17–53.PubMedGoogle Scholar Levitan , H. , Ziylan , Z. , Smith , Q.R. , Takasato , Y. , and Rapoport , S.I. , 1984 , Brain uptake of a food dye , erythrosin B(passive) prevented by17–53.PubMedGoogle Scholar Levitan , H. , Ziylan , Z. , Smith , Q.R. , Takasato , Y. , and Rapoport , S.I. , 1984 , Brain uptake of a food dye , erythrosin B

in more free drug available for hepatic metabolism Volume of Drug Distribution• Volume of distributionresultingin more free drug available for hepatic metabolism Volume of Drug Distribution• Volume of distribution

in more free drug available at the site of drug action / toxicity Organic acids that accumulate in renal failuremay resultin more free drug available at the site of drug action / toxicity Organic acids that accumulate in renal failure

to an increase in the free phenytoin fraction ( without increasing the total serum concentration of phenytoinmay leadto an increase in the free phenytoin fraction ( without increasing the total serum concentration of phenytoin

The stereoselectivity in brain distribution indicated by the partition coefficient Kp ( total AUC ratio brain to plasma(passive) was caused byThe stereoselectivity in brain distribution indicated by the partition coefficient Kp ( total AUC ratio brain to plasma

to the protein activationmay leadto the protein activation

the principal peaks in the absorption spectrumcausesthe principal peaks in the absorption spectrum

The plasma oncotic pressure(passive) is caused byThe plasma oncotic pressure

the movement of chemicals from blood to tissuecan influencethe movement of chemicals from blood to tissue

pharmacokinetics and interaction between pharma- ceuticals and substances in the bloodstreamsignificantly influencespharmacokinetics and interaction between pharma- ceuticals and substances in the bloodstream

in binding to proteins over 90 %resultingin binding to proteins over 90 %

the lowest volume of distribution ... because not being bound to proteins increases the chance it will reach deep into the tissues before it reaches the kidneyscreatesthe lowest volume of distribution ... because not being bound to proteins increases the chance it will reach deep into the tissues before it reaches the kidneys

in extensive ECMresultin extensive ECM

inappropriate metabolism and/or excretionhelps preventinappropriate metabolism and/or excretion

the formation of antibodiesinfluencethe formation of antibodies

to dermal fibrosis in diffuse cutaneous systemic sclerosisinevitably leadsto dermal fibrosis in diffuse cutaneous systemic sclerosis

from entering the posterior chamber of the eyeare preventedfrom entering the posterior chamber of the eye

blood clotscan causeblood clots

the free fraction of drug available to bind to its targetinfluencesthe free fraction of drug available to bind to its target

The distribution of cobalt in the body(passive) is also influenced byThe distribution of cobalt in the body

urinary excretionwill influenceurinary excretion

ASO activity and distribution to extra - hepatic tissues in a species - dependent manner and sets the stage to identify other strategies to enhance ASO potency in muscle tissuescan influenceASO activity and distribution to extra - hepatic tissues in a species - dependent manner and sets the stage to identify other strategies to enhance ASO potency in muscle tissues

to the formation of a complex fibrillar matrix composed primarily of fibrin and plasma fibronectinleadsto the formation of a complex fibrillar matrix composed primarily of fibrin and plasma fibronectin

to retinal edemacontributedto retinal edema

to heparin resistance , where very large doses are required to achieve anticoagulationcan leadto heparin resistance , where very large doses are required to achieve anticoagulation

to blood clot formationcontributesto blood clot formation

from the inhibition of tachykinin releaseresultingfrom the inhibition of tachykinin release

the increase in the δγ - T lymphocytes in Peyer ’s patches and in lamina propria , which supports the hypothesis that a SDP - supplemented diet can play a role in the modulation of the immune responsepreventsthe increase in the δγ - T lymphocytes in Peyer ’s patches and in lamina propria , which supports the hypothesis that a SDP - supplemented diet can play a role in the modulation of the immune response

in an increased unbound fractionresultingin an increased unbound fraction

from the patientscreatedfrom the patients

rapid mitosis of the hepatocytes and actual growth of liver , which is coupled with increase in synthesis of plasma proteins until blood values are again normal · Transaminationcausesrapid mitosis of the hepatocytes and actual growth of liver , which is coupled with increase in synthesis of plasma proteins until blood values are again normal · Transamination

diffusion of the compound through the fenestrated choroidal capillaries ... and permits better delineation of choroidal detailspreventsdiffusion of the compound through the fenestrated choroidal capillaries ... and permits better delineation of choroidal details

to slower elimination through the kidneysleadsto slower elimination through the kidneys

both the pharmacodynamic effects and the pharmacokinetic properties of peptidescan influenceboth the pharmacodynamic effects and the pharmacokinetic properties of peptides