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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

Multiple myeloma ( confirmed by appropriate serum or urine protein electrophoresis and bone marrow findings ) is considered disablinghas causedplasma cells ( 100 or more cells per cubic millimeter ) in the peripheral blood

by ability of organ eliminating target cells(passive) was influenced byplasma cells increase

a hormonecauseslymphocytes to develop into plasma cells

blood ... a rapidly rotating machinecausesplasma in the blood to separate from red blood cells

the tiny capillaries more leakyleadsto the plasma part of blood

antibodiesdiscoveredwithin the blood plasma

a form of blood cancercausesdegeneration of plasma cells

the hormonecausesplasma cells to develop

an overproduction of the hormonecausesplasma cells to develop

any drugcausingPLASMA CELLS PRESENT

other drugscausePLASMA CELLS PRESENT

ASPIRIN ... other drugscausePLASMA CELLS PRESENT

DEXAMETHASONE ... other drugscausePLASMA CELLS PRESENT

PREDNISONE ... other drugscausePLASMA CELLS PRESENT

a body fluidcomposedof blood cells suspended in the blood plasma

THALIDOMIDE ... other drugscausePLASMA CELLS PRESENT

In doing so , we compare ASPIRIN with other drugscausePLASMA CELLS PRESENT

THALIDOMIDEcausingPLASMA CELLS PRESENT

In vertebratesis composedof blood cells suspended in blood plasma

a disorderleadingto malignancy in plasma cells

In vertebrates , those same cellsiscomposedof blood cells suspended in blood plasma

an ample proteindiscoveredin the plasma ingredient of blood

an infiltratecomposedof IgG4-positive plasma cells

Multiple myeloma ... a type of blood canceroriginatesin plasma cells

localized tumorscomposedof monoclonal plasma cells

a type of blood canceroriginatesin plasma cells

a type of blood canceroriginatingin plasma cells

mass lesionscomposedof neoplastic plasma cells

lesioncomposedof polyclonal plasma cells

Multiple myeloma ... a blood canceroriginatesin plasma cells

blood cancercausesplasma cells

co - infection with other viruses(passive) caused byplasma cells

Multiple myeloma ( MM ... a bone marrow cancerinfluencesplasma cells

Many plasma miRNAs are knownto originatefrom peripheral blood mononuclear cells ( PBMC

any drugcausingPLASMA CELLS

DrugscausedPlasma Cells

The canceroriginatesfrom the Plasma Cells

canceroriginatesin plasma cells

a canceroriginatingfrom plasma cells

hematopoietic tissueresultingfrom plasma cells

from B lymphocytes produced in the bone marroworiginatefrom B lymphocytes produced in the bone marrow

almost 11,000 deaths each yearcausesalmost 11,000 deaths each year

Multiple myeloma(passive) is caused byMultiple myeloma

of watercomposedof water

in the bone marroworiginatingin the bone marrow

to disease severity of experimental autoimmune encephalomyelitiscontributeto disease severity of experimental autoimmune encephalomyelitis

in the bone marroworiginatesin the bone marrow

in the boneoriginatein the bone

painful , bone - destructive lesionscausespainful , bone - destructive lesions

of a high proportion of protein with little triglyceride and cholesterol and which concentration is associated with a decreased probability of developing coronary heart diseaseis composedof a high proportion of protein with little triglyceride and cholesterol and which concentration is associated with a decreased probability of developing coronary heart disease

to immunoglobulin proteinleadto immunoglobulin protein

to plasma cell malignancy diseases such as multiple myeloma ( MMleadsto plasma cell malignancy diseases such as multiple myeloma ( MM

to increased proliferation of these malignant cells and overproduction of M proteinleadingto increased proliferation of these malignant cells and overproduction of M protein

of a moderate proportion of protein with little triglyceride and a high proportion of cholesterolis composedof a moderate proportion of protein with little triglyceride and a high proportion of cholesterol

of a moderate proportion of protein with little triglyceride and a high proportion of cholesterolis composedof a moderate proportion of protein with little triglyceride and a high proportion of cholesterol

to immunoglobulin protein AAleadto immunoglobulin protein AA

to production of lesions due to inflammationleadto production of lesions due to inflammation

to end - organ damageleadingto end - organ damage

complement mediated damage to the graft cellscausecomplement mediated damage to the graft cells

from the germinal center reaction from T cell - dependent activation of B cellsresultfrom the germinal center reaction from T cell - dependent activation of B cells

in the abnormal accumulation of M - proteins ( also known as immunoglobulin M or IgM ) in the bloodresultsin the abnormal accumulation of M - proteins ( also known as immunoglobulin M or IgM ) in the blood

to the early generation of specific antibodiescontributeto the early generation of specific antibodies

to further antibody productionleadingto further antibody production

to antibody productionthereby leadingto antibody production

to bone marrow infiltration and bone destructionleadingto bone marrow infiltration and bone destruction

to production of lesionsleadto production of lesions

in high immunoglobulin levelsresultingin high immunoglobulin levels

to irreversible changes in tissuesleadingto irreversible changes in tissues

a wide variety of complications leading to organ dysfunction and eventually deathcausinga wide variety of complications leading to organ dysfunction and eventually death

within the bone marrow originatingwithin the bone marrow

to diseasecontributeto disease

in the observed monoclonal protein ( M - proteinresultingin the observed monoclonal protein ( M - protein

in the bone marrow 1originatein the bone marrow 1

from the bone marrow produce immunoglobulin moleculesoriginatingfrom the bone marrow produce immunoglobulin molecules

an increased secretion of paraprotein [ 1causingan increased secretion of paraprotein [ 1

to the development of Memory B - cellsthen leadto the development of Memory B - cells

to their productioncontributeto their production

in diffuse organ swelling , tissue - destructive lesions and fibrosisresultingin diffuse organ swelling , tissue - destructive lesions and fibrosis

widespread osteolytic bone damagecauseswidespread osteolytic bone damage

diseases such as in autoimmune conditions and cancers of plasma cells , called multiple myelomacan causediseases such as in autoimmune conditions and cancers of plasma cells , called multiple myeloma

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Smart Reasoning:

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