bone absorption and the arrival of calcium from bone to serumcausebone absorption and the arrival of calcium from bone to serum

in the boneoriginatein the bone

a blood cancer(passive) caused bya blood cancer

to MM progressionleadingto MM progression

from monoclonal proliferation of plasma cellsresultfrom monoclonal proliferation of plasma cells

to plasma cell malignancy diseases such as multiple myeloma ( MMleadsto plasma cell malignancy diseases such as multiple myeloma ( MM

to pancytopenia ( low level of all blood cell typesleadingto pancytopenia ( low level of all blood cell types

from the bone marrow from those out of control plasma cellsoriginatefrom the bone marrow from those out of control plasma cells

to production of lesions due to inflammationleadto production of lesions due to inflammation

to a range of symptomsleadingto a range of symptoms

to end - organ damageleadingto end - organ damage

in a transient ( 6 month ) depletion of > 60 % of circulating B - cellsresultsin a transient ( 6 month ) depletion of > 60 % of circulating B - cells

complement mediated damage to the graft cellscausecomplement mediated damage to the graft cells

from the germinal center reaction from T cell - dependent activation of B cellsresultfrom the germinal center reaction from T cell - dependent activation of B cells

malignant bone marrow disease(passive) caused bymalignant bone marrow disease

The The differential diagnosis in cases without circulating number of circulating myeloma cells(passive) has been setThe The differential diagnosis in cases without circulating number of circulating myeloma cells

to further antibody productionleadingto further antibody production

to antibody productionthereby leadingto antibody production

to bone marrow infiltration and bone destructionleadingto bone marrow infiltration and bone destruction

in high immunoglobulin levelsresultingin high immunoglobulin levels

to irreversible changes in tissuesleadingto irreversible changes in tissues

a wide variety of complications leading to organ dysfunction and eventually deathcausinga wide variety of complications leading to organ dysfunction and eventually death

within the bone marrow originatingwithin the bone marrow

within the bone marrowdiscoveredwithin the bone marrow

the diseasecausethe disease

the diseasecausingthe disease

in the observed monoclonal protein ( M - proteinresultingin the observed monoclonal protein ( M - protein

in the bone marrow 1originatein the bone marrow 1

from the bone marrow produce immunoglobulin moleculesoriginatingfrom the bone marrow produce immunoglobulin molecules

an increased secretion of paraprotein [ 1causingan increased secretion of paraprotein [ 1

to their productioncontributeto their production

widespread osteolytic bone damagecauseswidespread osteolytic bone damage

diseases such as in autoimmune conditions and cancers of plasma cells , called multiple myelomacan causediseases such as in autoimmune conditions and cancers of plasma cells , called multiple myeloma

from the abnormal proliferation of malignant plasma cells within the bone marrow ( BM ) microenvironmentresultingfrom the abnormal proliferation of malignant plasma cells within the bone marrow ( BM ) microenvironment

to the formation of white blood cellscontributeto the formation of white blood cells

of one light chain type and one heavy chain typeoverwhelmingly composedof one light chain type and one heavy chain type

in the bone marrow 1 Myelomaoriginatein the bone marrow 1 Myeloma

in the bone marrow and help the immune systemoriginatein the bone marrow and help the immune system

to release andleadingto release and

this effectis causingthis effect