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Qaagi - Book of Why

Causes

Effects

the spread of cells into the bloodstreammay leadto the development of plasma cell leukemia ( 8)

the bloodstreammay leadto the development of plasma cell leukemia ( 8)

the expression of CD138 ... the bloodstreammay leadto the development of plasma cell leukemia ( 8)

environmental and industrial elementscan contributeto development of Plasma Cell Leukemia

the expression of CD138 ... the bloodstreammay leadto the development of plasma cell leukemia

The terminal stage of myeloma progression ... stroma - independent growthresultsin extramedullary diseases and plasma cell leukemia

a protease inhibitorcausingapoptosis of plasma cell

any drugcausingPLASMA CELL DISORDER

ASPIRIN ... other drugscausePLASMA CELL DISORDER

not METHOTREXATEcausesPLASMA CELL DISORDER

the key agentcan causecell death in leukemia

1]. Hematological evaluation is criticalto discoverplasma cell disorders

Hematological evaluation is criticalto discoverplasma cell disorders

Hematological evaluation ... criticalto discoverplasma cell disorders

the reason for that ... the onescauseplasma cell leukemia

by human T cell leukemia virus 1(passive) caused byT - cell leukemia

chronic antigenic stimulation(passive) is caused byPlasma cell hyperplasia

Regulatory protein essential for hematopoietic development Inappropriate overexpression in T cellscontributesto T - cell leukemia

n : human T - cell leukemia virus-1 , HTLV-1 } retroviruscausingT - cell leukemia

by human T lymphotropic virus ( HTLV(passive) caused byT - Cell leukemia

human T lymphotropic virus ( HTLV(passive) caused byT - Cell leukemia

Human T - cell lymphotropic virus-1 ( HTLV-1 ... ableto causeT - cell leukemia

human T - cell leukemia virus-1 - retroviruscausingT - cell leukemia

a regulatory protein that is essential for hematopoietic development and inappropriate overexpression of Lmo2 in T - cellscontributesto T - cell leukemia

The human T - lymphotropic viruscan resultin T - cell leukemia

a possibilitycould causePlasma Cell Leukaemia

Human T - lymphotropic virus ( HTLV ) , of which there are several species ... a human , single - stranded RNA retroviruscausesT - cell [ [ leukemia

the conditional deletion of EZH2 in bone marrow cellscausesT - cell leukemia

if you engineered a constitutively active form of the Notch protein into micecould leadto T - cell leukemia

T cell lymphotropic virus ( HTLV)-1can causeT cell leukemia

Inappropriate activation of the Notch pathway in the human immune systemcausesT - cell leukemia

feline leukemia virus ( FeLVcan causeT - cell leukemia

An active infection with HTLV-1leadsto T - cell leukemia

the signaling mechanismscan leadto T cell leukemia

Infection by HTLV-1can leadto T - cell leukemia

Another virus under investigation ... which appearsto causeT - cell leukemia

What viruscausesT cell leukemia

a viruscausesT - cell leukemia

the viruscausesT - cell leukemia

HTLV-1 - retroviruscausingT - cell leukemia

in the bone marroworiginatesin the bone marrow

an overproduction of plasma cellscausesan overproduction of plasma cells

bone destructioncausesbone destruction

to skeletalleadingto skeletal

in the bone marroworiginatesin the bone marrow

them to swell up or look fullcausingthem to swell up or look full

in the boneoriginatein the bone

in the formation of osteosclerotic lesions in bonecan also resultin the formation of osteosclerotic lesions in bone

symptomsmay causesymptoms

Multiple myeloma(passive) is caused byMultiple myeloma

from the comparatively slow development of plasma cell / plasma cell precursor genetic abnormalities which initially create a clone of cells that cause the premalignant condition of monoclonal gammopathy of undetermined significanceresultsfrom the comparatively slow development of plasma cell / plasma cell precursor genetic abnormalities which initially create a clone of cells that cause the premalignant condition of monoclonal gammopathy of undetermined significance

from monoclonal proliferation of plasma cellsresultfrom monoclonal proliferation of plasma cells

fatigue and frequent infectionsmay causefatigue and frequent infections

as the primary manifestation of the diseasecan originateas the primary manifestation of the disease

to plasma cell malignancy diseases such as multiple myeloma ( MMleadsto plasma cell malignancy diseases such as multiple myeloma ( MM

in the bone marroworiginatedin the bone marrow

apoptosiscausingapoptosis

a significant morbidity due to organ damage and bone tissue destructioncausesa significant morbidity due to organ damage and bone tissue destruction

swelling in the liver , kidneys , or spleenhave causedswelling in the liver , kidneys , or spleen

from clonal expansion ofresultfrom clonal expansion of

lesions(passive) caused bylesions

in PPs and possibly other sites of B cell activationoriginatein PPs and possibly other sites of B cell activation

in soft tissuesoriginatesin soft tissues

from a B cell and produces antibodies as part of a humoral immune responseoriginatesfrom a B cell and produces antibodies as part of a humoral immune response

from a cancerous growth of white blood cellsresultsfrom a cancerous growth of white blood cells

AL amyloidosis(passive) caused byAL amyloidosis

damage of multiple organs with fatal consequences for patientscausingdamage of multiple organs with fatal consequences for patients

from a chromosomal translocationalso resultsfrom a chromosomal translocation

light chain tubulopathycausinglight chain tubulopathy

light chain tubulopathy without Fanconi syndromecausinglight chain tubulopathy without Fanconi syndrome

in the thymusoriginatesin the thymus

a malignant pleural effusioncan also causea malignant pleural effusion

a very high level of white blood cellscausesa very high level of white blood cells

allergic or anaphylactic reactions in some patientscould causeallergic or anaphylactic reactions in some patients

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