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Qaagi - Book of Why

Causes

Effects

of multiple myeloma ( MM ) , and primary and secondary plasma cell leukemia(passive) are composedPlasma cell dyscrasias

a drug or a condition(passive) caused byplasma cell dyscrasia

An abnormal proliferation of one type ( or clone ) orcan leadplasma cell

pathwayspreventplasma cell apoptosis

light chainsresultingfrom plasma - cell dyscrasia

the Muliple Meloma and the prognosis(passive) is caused byplasma cell Leukimia

to be most numerous within the lymphoid aggregates ( Figure 2 , D ) and less prominent within the fibrosclerotic tracts(passive) were discoveredIgG4-positive plasma cells

Chen , D , Ireland , SJ , Davis , LS , Kong , X , Stowe , AM , Wang , Y , White , WI , Herbst , R & Monson , NL 2016contributeAutoreactive CD19+CD20- plasma cells

Jean - Pierre [ UCL ] AL amyloidosis ... whose productionresultsfrom a plasma cell dyscrasia

the oncogenic eventscauseplasma cell malignancy

the antibodycreatingplasma cell

Clobetasol Propionatecould ... causePlasma Cell Dyscrasia

systemic amyloidosisresultingfrom plasma cell dyscrasia

Epstein - Barr virus infection is knownto causeplasma cell

normal aging(passive) caused byPlasma cell cheilitis ,

Two main types of EVs ... the microparticlesoriginatefrom cell plasma memb

any chanceto triggerplasma cell

NCT00344526 AL amyloidosis(passive) is caused byNCT00344526 AL amyloidosis

Acquired AL amyloidosis(passive) caused byAcquired AL amyloidosis

Fujioka Y. Severe pulmonary hypertension(passive) caused byFujioka Y. Severe pulmonary hypertension

a protein conformation disorder(passive) caused bya protein conformation disorder

381 - 388 AL amyloidosis(passive) is caused by381 - 388 AL amyloidosis

a wide variety of complications leading to organ dysfunction and eventually death [ 14causinga wide variety of complications leading to organ dysfunction and eventually death [ 14

117 - 118a , November 16 AL amyloidosis(passive) is caused by117 - 118a , November 16 AL amyloidosis

7 pagesdoi:10.1155/2012/836893 Case Report Severe Pulmonary Hypertension(passive) Caused by7 pagesdoi:10.1155/2012/836893 Case Report Severe Pulmonary Hypertension

in inflammatory lesions and fibrosisresultingin inflammatory lesions and fibrosis

poems syndrome , steroid - dependent diabetes mellitus , rheumatoid arthritis , RA , and skin vasculitis in our patient(passive) were triggered bypoems syndrome , steroid - dependent diabetes mellitus , rheumatoid arthritis , RA , and skin vasculitis in our patient

from the clonal proliferation of malignant plasma cells ( PC ) within the bone marrow ( BMresultingfrom the clonal proliferation of malignant plasma cells ( PC ) within the bone marrow ( BM

to disease severity of experimental autoimmune encephalomyelitis — University of Texas Southwestern Medical Center Autoreactive CD19+CD20- plasma cells contribute to disease severity of experimental autoimmune encephalomyelitiscontributeto disease severity of experimental autoimmune encephalomyelitis — University of Texas Southwestern Medical Center Autoreactive CD19+CD20- plasma cells contribute to disease severity of experimental autoimmune encephalomyelitis

along with decreased levels of normal immunoglobulinscan leadalong with decreased levels of normal immunoglobulins

in diffuse organ swelling , tissue - destructive lesions , and fibrosisresultingin diffuse organ swelling , tissue - destructive lesions , and fibrosis

to the Neoplastic proliferation of plasma cell which produce Ig and Ig Fragmentsleadto the Neoplastic proliferation of plasma cell which produce Ig and Ig Fragments

to 1.89 % of all plasma cell dyscrasiascontributingto 1.89 % of all plasma cell dyscrasias

from clonal expansion of plasma cells which produce large amount of M - proteinresultfrom clonal expansion of plasma cells which produce large amount of M - protein

to over production of one clone of B - lymphocytes and its antibody proteinleadsto over production of one clone of B - lymphocytes and its antibody protein

biopsy - proven systemic ALcausingbiopsy - proven systemic AL

when certain cells in the blood ( called plasma cells ) become cancerousresultwhen certain cells in the blood ( called plasma cells ) become cancerous

diffuse infiltrates(passive) to be caused bydiffuse infiltrates

in excess production of immunoglobulin protein chainsresultin excess production of immunoglobulin protein chains

stretch injury causes vulval cancer causes inflammatory arthritis causes partial retinal detachment causes bacterial prostatitis causes endplate osteophyte causes renal parenchymal cysts causes renal cystic disease causes posterior episcleritis causescausesstretch injury causes vulval cancer causes inflammatory arthritis causes partial retinal detachment causes bacterial prostatitis causes endplate osteophyte causes renal parenchymal cysts causes renal cystic disease causes posterior episcleritis causes

plasma cells to manufacture the M protein antibody , a fault that leads to abnormally thick bloodcan causeplasma cells to manufacture the M protein antibody , a fault that leads to abnormally thick blood

no anemia , hypercalcemia or renal impairment(passive) caused byno anemia , hypercalcemia or renal impairment

from terminally differentiated B lymphocytes that have undergone malignant transformationoriginatefrom terminally differentiated B lymphocytes that have undergone malignant transformation

from differences of inside versus outside concentration of potassium , sodium , chloride , and other ions across cells ' or ORGANELLES membranesresultfrom differences of inside versus outside concentration of potassium , sodium , chloride , and other ions across cells ' or ORGANELLES membranes

a rare paraneoplastic disorder(passive) caused bya rare paraneoplastic disorder

in extensive fibrosisresultingin extensive fibrosis

cardiac and muscle hypertrophycausedcardiac and muscle hypertrophy

in abnormal extracellular deposition of fibrillary protein which can occur in association with multiple myeloma [ 1resultingin abnormal extracellular deposition of fibrillary protein which can occur in association with multiple myeloma [ 1

Some of the narrowing(passive) is caused bySome of the narrowing

Fanconi syndrome , a type 2 proximal renal tubular acidosis characterized by hypophosphatemia and inappropriate glycosuriamay also causeFanconi syndrome , a type 2 proximal renal tubular acidosis characterized by hypophosphatemia and inappropriate glycosuria

to monoclonal light - chain deposition ... with cardiac involvement occurring in up to 50 % of casesleadsto monoclonal light - chain deposition ... with cardiac involvement occurring in up to 50 % of cases

in myeloma - defining events ( end - organ damage and/or biomarkers of malignancyresultingin myeloma - defining events ( end - organ damage and/or biomarkers of malignancy

microengineered networks of endothelial cellscreatesmicroengineered networks of endothelial cells

Changes in the blood(passive) caused byChanges in the blood

via an autoimmune mechanism to the typical histologic findings - storiform fibrosis ( " storiform " = whorled ... like a straw matleadsvia an autoimmune mechanism to the typical histologic findings - storiform fibrosis ( " storiform " = whorled ... like a straw mat

big amounts of antibodiescreatesbig amounts of antibodies

POEMS syndrome presenting with severe PH(passive) caused byPOEMS syndrome presenting with severe PH

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