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Qaagi - Book of Why

Causes

Effects

Loss of NRF-2 and PGC-1 genesleadsto retinal pigment epithelium damage

nutrientscausingpigment discoloration and wall detachment

surgical trauma during the creation of the initial flap in the ILM and from the abrasive suctioning on the floor of macular hole(passive) is caused byretinal pigment epithelium damage

long - term oxidative stress(passive) is mainly caused byRetinal pigment epithelium ( RPE ) degeneration

any drugcausingRETINAL PIGMENT EPITHELIAL TEAR

THERAPYcausesRETINAL PIGMENT EPITHELIAL TEAR

other drugscauseRETINAL PIGMENT EPITHELIAL TEAR

UV - radiation(passive) caused byRemoval of pigment lesions

bone spicule formation , 2 a waxy appearance of the optic nerve , and 3 the attentuation of blood vessels in the retina(passive) caused bythe retinal pigment epithelium RPE

GAresultingfrom flattening of a retinal pigment epithelial detachment

molecular defects in more than 40 different genes(passive) caused byretinal pigment epithelium ( RPE ) dystrophies

Natural vitaminscontributeto retinal pigment epithelium regeneration

other drugscauseDETACHMENT OF RETINAL PIGMENT EPITHELIUM

by bony spicule formation , ( 2 ) a waxy appearance of the optic nerve , and ( 3 ) the attenuation of blood vessels in the retina.[3(passive) caused bythe retinal pigment epithelium ( RPE

by bone spicule formation , 2 a waxy appearance of the optic nerve(passive) caused bythe retinal pigment epithelium RPE

by bone spicule formation(passive) caused bythe retinal pigment epithelium RPE

by molecular defects in multiple genes(passive) caused byretinal pigment epithelium dystrophies

by the deposits(passive) caused bythe retinal pigment epithelium ( RPE

the outer layeris composedof retinal pigment epithelium ( RPE

by drusen(passive) caused byretinal pigment epithelial detachments

bone retinitis pigmentaria formation(passive) caused bythe retinal pigment epithelium RPE

CMR ... a gene mutationcausespigment epithelium athrophy

drusen , which results in reduced intensity at Bruch 's membrane equivalent(passive) caused byretinal pigment epithelial detachments

by drusen , which results in reduced intensity at Bruch 's membrane equivalent(passive) caused byretinal pigment epithelial detachments

Commoncauseretinal pigment epithelium

the c - wave is knownto originatefrom the retinal pigment epithelium

This avascular focal leakagecausedin the retinal pigment epithelium

by non - neovascular age - related macular degeneration(passive) caused bypigment epithelium detachment

unwanted melanincausepigment lesions

melanincausingshattering of the melanin pigment

hemolysiscausingpigment nephropathy

any drugcausingPIGMENT NEPHROPATHY

rhabdomyolysis(passive) caused bypigment nephropathy (

rhabdomyolysiscausingpigment nephropathy

that most of the cysts were of primary etiologyoriginatedfrom the pigment epithelium

strong acoustic waves generated during the interaction between ESP laser pulses and the pigment particles(passive) caused bypigment disintegration

before taking a break-can causeworsening of pigment

carcausesexcretion of pigment

its depigmentation and focal destruction in the absence of RPE and excrescences in inner segment - outer segment ( IS - OS ) junction(passive) caused bythe pigment epithelium

some E locus mutationscauseepidermal pigment

in atrophyresultingin atrophy

central blindnesscausingcentral blindness

to complete blindnesssometimes leadingto complete blindness

to outer retinal and inner choroidal degenerationleadsto outer retinal and inner choroidal degeneration

the black dotscausethe black dots

to AMDleadto AMD

to leakage into the outer retina from the choriocapillaries and impaired fluid clearance by the retinal pigment epitheliumleadingto leakage into the outer retina from the choriocapillaries and impaired fluid clearance by the retinal pigment epithelium

to a loss of visual function over timecan leadto a loss of visual function over time

to photoreceptor degeneration of the overlying central retina , or maculaleadsto photoreceptor degeneration of the overlying central retina , or macula

in subsequent degeneration of the photoreceptorsresultingin subsequent degeneration of the photoreceptors

dysregulation of the photoreceptor cells ... and eventually cell deathcausesdysregulation of the photoreceptor cells ... and eventually cell death

to photoreceptor ( PR ) degeneration and blindnessleadsto photoreceptor ( PR ) degeneration and blindness

to outer retinal and inner choroidal degenerationleadsto outer retinal and inner choroidal degeneration

to vision lossleadingto vision loss

blindnesscan causeblindness

from effective BRAF + MEK inhibitionresultingfrom effective BRAF + MEK inhibition

loss of shading in the skin , hair , retina , and so oncausesloss of shading in the skin , hair , retina , and so on

AKIcausesAKI

AKIcausesAKI

to RPE andleadsto RPE and

to neovascularizationcontributesto neovascularization

in vision lossmay resultin vision loss

to cell deathleadingto cell death

to retinal cell death and tissue alterationsleadsto retinal cell death and tissue alterations

the slow destruction of the cells in the maculacausesthe slow destruction of the cells in the macula

to blindnesscan leadto blindness

various retinal diseases(passive) caused byvarious retinal diseases

macular degeneration and loss of visioncan ... causemacular degeneration and loss of vision

to the outer portion of the blood retinal barriercontributesto the outer portion of the blood retinal barrier

a detachment of the neurosensory retinacausinga detachment of the neurosensory retina

macula degeneration over the long termcan causemacula degeneration over the long term

age - related macular degenerationthereby causingage - related macular degeneration

RPE ) dysfunction or cell deathcan leadRPE ) dysfunction or cell death

to age - related degeneration of the maculaleadto age - related degeneration of the macula

postnatal visual developmentinfluencespostnatal visual development

on the maculacausingon the macula

lesions on the maculacausinglesions on the macula

to its atrophyleadingto its atrophy

dry macular degeneration(passive) is caused bydry macular degeneration

to permanent visual lossleadingto permanent visual loss

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