the electron - withdrawing heteroatom adjacent to C4 ' benefits the interaction of the inhibitor and ER[alpha(passive) caused byphenyl ring electronegativity
C - O bond ... helpspreventhydrogenation of the phenyl ring
this smaller volumesettingthe benzylidene phenyl ring
the CH bonds and the NH2 groups(passive) caused bythe phenyl rings
the interparticle interactions ( indicated by yellow dashed linesare ... originatedfrom phenyl ring H to phenyl ring
the inversion of isoxazoline ring – its isomer 17a(passive) caused bythe phenyl rings
a bonding hydrogen atom donorcomposedof phenyl ring
to the quenching of fluorescenceleadsto the quenching of fluorescence
in a low enough triplet energy to quench green phosphorescent emissionmay resultin a low enough triplet energy to quench green phosphorescent emission
physisorption of the macrocyclepreventingphysisorption of the macrocycle
to rapid decay of the excited statesleadingto rapid decay of the excited states
to a stronger π - π interactionleadingto a stronger π - π interaction
a π - π interaction with Tyr407createsa π - π interaction with Tyr407
in torsion angles of -179.1 ( 7resultingin torsion angles of -179.1 ( 7
to MCG315 , a stronger inhibitor of PARP-1 , -3 , and -16 and more potent CFTR correctorledto MCG315 , a stronger inhibitor of PARP-1 , -3 , and -16 and more potent CFTR corrector
to the increase and improvement of the cytotoxic effectsledto the increase and improvement of the cytotoxic effects
to SHU9119 , a superpotent antagonist at the melanocortin 3 and 4 receptors , which demonstrates the drastic change in biological action that a small change in structure can induceledto SHU9119 , a superpotent antagonist at the melanocortin 3 and 4 receptors , which demonstrates the drastic change in biological action that a small change in structure can induce
on average a 27-fold reduction of potency relative to 5qcausedon average a 27-fold reduction of potency relative to 5q
TNT - b8 to TNT - b14(passive) were composedTNT - b8 to TNT - b14
sixfold phenyl embraces interpenetrating with the polar networksresultingsixfold phenyl embraces interpenetrating with the polar networks
in a higher band - gap and higher oxidation potentialresultingin a higher band - gap and higher oxidation potential
to CNB-023ledto CNB-023
to benzyl and silabenzyl cationsleadingto benzyl and silabenzyl cations
from the azide reactantoriginatingfrom the azide reactant
a high cytotoxicity against Hela cellscauseda high cytotoxicity against Hela cells
to the lower solubility of derivative 4ledto the lower solubility of derivative 4
to 3-[3-(3-chloro-5-trifluoromethyl-2-pyridinyloxy)-4-chloro-6-hydroxyphenyl]urealeadingto 3-[3-(3-chloro-5-trifluoromethyl-2-pyridinyloxy)-4-chloro-6-hydroxyphenyl]urea
to compound 8ledto compound 8
of C12 / C13–C17 ] andcomposedof C12 / C13–C17 ] and
to a 100-fold reduction in action [ 33ledto a 100-fold reduction in action [ 33
to many further studies and revelations as to the full nature of genetically caused errors of metabolismledto many further studies and revelations as to the full nature of genetically caused errors of metabolism
to the differences between drugscontributesto the differences between drugs
the formation of 3D crosslinked polymercausingthe formation of 3D crosslinked polymer