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Qaagi - Book of Why

Causes

Effects

the electron - withdrawing heteroatom adjacent to C4 ' benefits the interaction of the inhibitor and ER[alpha(passive) caused byphenyl ring electronegativity

272 - 276 Full AccessRestricted Access Interlocked macrocyclescomposed exclusivelyof phenyl rings

The firstcausesthe phenyl rings

aromatic ringsoriginatefrom the phenyl rings

C - O bond ... helpspreventhydrogenation of the phenyl ring

this smaller volumesettingthe benzylidene phenyl ring

the CH bonds and the NH2 groups(passive) caused bythe phenyl rings

the interparticle interactions ( indicated by yellow dashed linesare ... originatedfrom phenyl ring H to phenyl ring

the inversion of isoxazoline ring – its isomer 17a(passive) caused bythe phenyl rings

a bonding hydrogen atom donorcomposedof phenyl ring

to the quenching of fluorescenceleadsto the quenching of fluorescence

in a low enough triplet energy to quench green phosphorescent emissionmay resultin a low enough triplet energy to quench green phosphorescent emission

physisorption of the macrocyclepreventingphysisorption of the macrocycle

to rapid decay of the excited statesleadingto rapid decay of the excited states

to a stronger π - π interactionleadingto a stronger π - π interaction

a π - π interaction with Tyr407createsa π - π interaction with Tyr407

in torsion angles of -179.1 ( 7resultingin torsion angles of -179.1 ( 7

to MCG315 , a stronger inhibitor of PARP-1 , -3 , and -16 and more potent CFTR correctorledto MCG315 , a stronger inhibitor of PARP-1 , -3 , and -16 and more potent CFTR corrector

to the increase and improvement of the cytotoxic effectsledto the increase and improvement of the cytotoxic effects

to SHU9119 , a superpotent antagonist at the melanocortin 3 and 4 receptors , which demonstrates the drastic change in biological action that a small change in structure can induceledto SHU9119 , a superpotent antagonist at the melanocortin 3 and 4 receptors , which demonstrates the drastic change in biological action that a small change in structure can induce

on average a 27-fold reduction of potency relative to 5qcausedon average a 27-fold reduction of potency relative to 5q

TNT - b8 to TNT - b14(passive) were composedTNT - b8 to TNT - b14

sixfold phenyl embraces interpenetrating with the polar networksresultingsixfold phenyl embraces interpenetrating with the polar networks

in a higher band - gap and higher oxidation potentialresultingin a higher band - gap and higher oxidation potential

to CNB-023ledto CNB-023

to benzyl and silabenzyl cationsleadingto benzyl and silabenzyl cations

from the azide reactantoriginatingfrom the azide reactant

a high cytotoxicity against Hela cellscauseda high cytotoxicity against Hela cells

to the lower solubility of derivative 4ledto the lower solubility of derivative 4

to 3-[3-(3-chloro-5-trifluoromethyl-2-pyridinyloxy)-4-chloro-6-hydroxyphenyl]urealeadingto 3-[3-(3-chloro-5-trifluoromethyl-2-pyridinyloxy)-4-chloro-6-hydroxyphenyl]urea

to compound 8ledto compound 8

of C12 / C13–C17 ] andcomposedof C12 / C13–C17 ] and

to a 100-fold reduction in action [ 33ledto a 100-fold reduction in action [ 33

to many further studies and revelations as to the full nature of genetically caused errors of metabolismledto many further studies and revelations as to the full nature of genetically caused errors of metabolism

to the differences between drugscontributesto the differences between drugs

the formation of 3D crosslinked polymercausingthe formation of 3D crosslinked polymer

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