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Qaagi - Book of Why

Causes

Effects

Leakage of fluid from these vessels at the maculacan resultin diabetic macular edema ( swelling

the amount of VEGF and other inflammatory cytokines produced by cells ( a process called " downregulationcan leadto a reduction of diabetes - related macular edema

Oxidative stresscausesdiabetes Cerebral edema

other factorscontributingto macular edema than diabetes

insulin deficiency and insulin resistance(passive) is caused byHyperglycemia in diabetes

by circulatory problems(passive) caused bydiabetic foot and edema

circulatory problems(passive) caused bydiabetic foot and edema

ValuesetDiabetic Macular Edema ( 2.16.840.1.113883.3.526.3.1455

A number of medications appearto causepedal edema ( foot edema

Drugscausehyperglycemia in diabetes

these changescan leada condition called diabetic macular edema

a complication of diabetes called diabetic retinopathy(passive) is caused byDiabetic macular edema ( DME

elevated plasma glucagoncontributedto hyperglycemia in diabetes

by leaking fluid(passive) is caused byDME ( Diabetic Macular Edema

the accumulation of fluid in the central portion of the eye(passive) is caused byDME ( Diabetic Macular Edema

the scope of these studies has focused on the effect of FOXO1 on mRNA levels of genes that increase glucose productioncontributingto hyperglycemia in diabetes

relative hyperglucagonemiamight influencehyperglycemia in diabetes

by diabetic retinopathy(passive) Caused byDiabetic macular edema ( DME

by diabetic retinopathy(passive) is caused byDiabetic macular edema ( DME

diabetic retinopathy(passive) is caused byDiabetic macular edema ( DME

fluid accumulation in the macula(passive) is caused byDiabetic Macular Edema , DME

a breakdown in the blood - retinal barrier where fluid from the retinal capillaries and blood vessels leak and build up in the macular area(passive) is caused byDiabetic macular edema

fluid accumulation in the (passive) is caused byDiabetic Macular Edema , DME

Leakage of fluid from these vessels at the maculacan resultin diabetic macular edema

the result of fluid leaking into the retinacausingdiabetic macular edema

by vessel leakage and blood retinal barrier breakdown(passive) caused bydiabetic macular edema

the increase in retinal capillary permeabilityresultsin diabetic macular edema

retinal vascular functionleadingto diabetic macular edema

retinal capillary permeabilityresultsin diabetic macular edema

blood vessels to leakresultingin diabetic macular edema

Blurred vision : This can be the result of fluid leaking into the retinacausingdiabetic macular edema

vascular permeabilityleadingto diabetic macular edema

the rise in retinal capillary permeabilityresultsin diabetic macular edema

leaking macular capillaries(passive) is similarly caused byDiabetic macular edema

Damaged blood vessels can also swell and leak fluid into the macula ( which is responsible for sharp , central visionleadingto diabetic macular edema

some other causescan leadto edema with diabetic nephropathy

In early DR , VEGF induced vascular hyperpermeabilitycould contributeto diabetic macular edema

leaking vessels that can cause bleeding and swelling of the macula which is responsible(passive) is caused byDiabetic macular edema

This leakageresultsin diabetic macular edema

the retina to swellleadingto diabetic macular edema

blurred vision and blindnesscan causeblurred vision and blindness

in blindnesscan resultin blindness

to blindnesscan leadto blindness

vision loss or blindnesscan causevision loss or blindness

from diabetic retinopathy and causes a buildup of fluid in the macularesultsfrom diabetic retinopathy and causes a buildup of fluid in the macula

to kidney failurecan leadto kidney failure

vision losscan causevision loss

the swelling(passive) caused bythe swelling

the swelling(passive) caused bythe swelling

to vision loss problem in Diabetic patientsleadsto vision loss problem in Diabetic patients

to permanent visual loss if it is left untreatedcan leadto permanent visual loss if it is left untreated

to permanent visual loss if it is left untreatedcan leadto permanent visual loss if it is left untreated

a Neck HeadacheCausesa Neck Headache

to death of vascular cells and neurons in the retinacan leadto death of vascular cells and neurons in the retina

to cardiovascular complications induced by oxidative stress ( 1leadsto cardiovascular complications induced by oxidative stress ( 1

to endothelial injury and nephropathy , retinopathy and atherosclerosisleadsto endothelial injury and nephropathy , retinopathy and atherosclerosis

to visual disabilitycan leadto visual disability

to oxidative stresscould leadto oxidative stress

to oxidative stressleadsto oxidative stress

to osmotic swelling of the nervescan leadto osmotic swelling of the nerves

abnormal carbohydrate metabolism and the production of advanced glycation end productscausesabnormal carbohydrate metabolism and the production of advanced glycation end products

the same oxidation stress(passive) caused bythe same oxidation stress

to increased protein glycation resulting in structural and functional alteration in proteinsleadsto increased protein glycation resulting in structural and functional alteration in proteins

from a hyperlipidemia conditionmay resultfrom a hyperlipidemia condition

diabetes insipidus(passive) is caused bydiabetes insipidus

Thoughmay causeThough

diabetes during pregnancycausesdiabetes during pregnancy

swelling(passive) caused byswelling

during pregnancycausesduring pregnancy

swelling in the retinacausesswelling in the retina

afferent glomerular arteriolar vasodilation leading to glomerular hyperfiltration which over a period of time results in glomerulosclerosis and eventual end stage renal failurecausesafferent glomerular arteriolar vasodilation leading to glomerular hyperfiltration which over a period of time results in glomerulosclerosis and eventual end stage renal failure

to vision losscan leadto vision loss

central vision losscan causecentral vision loss

to blindnesscan leadto blindness

to complications that reduce blood flowcan leadto complications that reduce blood flow

alsocan ... causealso

blurred vision and severe vision loss leading to blindnesscan causeblurred vision and severe vision loss leading to blindness

severe vision loss leading to blindnesscan causesevere vision loss leading to blindness

macular edema ( swelling )(passive) caused bymacular edema ( swelling )

swelling in the center part of the eye ( maculacausesswelling in the center part of the eye ( macula

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