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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

the best peak shapes ... highly active or difficult compoundscausepeak tailing

secondary interactions between an analyte and the columnmay causepeak tailing

undesirable adsorption of basic or polar moleculesmay causepeak tailing

adsorption to tubing(passive) caused bypeak tailing

Basic , polar analytes analysed using Type I and Type II silica Mobile phase pH will affect the degree of silanol ionisation and therefore the degree with which they interact with polar and ionisable analytescausingpeak tailing

The ionized silanol ... cation - exchange modecausespeak tailing

unwanted secondary interactions with active sites within the liner , packing material or inlet seal(passive) caused bypeak tailing

non - specific interactions(passive) caused bypeak tailing

Insufficient buffering of mobile phase Insufficient buffer concentration ... increased secondary interactionscausepeak tailing

adsorption or extracolumn band broad - ening(passive) is typically caused byPeak tailing

The carboxylic acid ... the amine salt complex competes with active sites on the chiral columncan causepeak tailing

The scattering process also normally broadens chromatography peaks ,causingpeak tailing

The fittings seal the tubing connection in such a way that minimizes dead volume helpsto preventpeak tailing

dead volume in joints ... helpspreventpeak tailing

The presence of highly active silanol sitescan causepeak tailing

radial temperature gradientcan ... causepeak tailing

a ratiowill causepeak tailing

proper column positioning ... sufficientto preventpeak tailing

The end - capped silica gel , however , retains more or less silanol groups unchangedcausingpeak tailing

that has high metal - affinityto causepeak tailing

basic side chains ... free silanolscausepeak tailing

their binding to free silanolscausepeak tailing

the large amount of triclosan in the column(passive) caused bypeak tailing

the secondary interactioncausespeak tailing

trace metal contaminantscan causepeak tailing

the reaction between the components to be tested and the acidic silanol groups(passive) caused bythe peak tailing

heavy metals that were thoughtto causepeak tailing

chemical issues(passive) caused byPeak tailing

a large C(7.0 ... activated silanolscausepeak tailing

This procedure ... an increase in hydroxyl groups on the glass or silicate surfaceswill ... causepeak tailing

the subsequent build custom forex systems with c tion of analytes ... helpspreventpeak tailing

Aluminium , iron and lead are particularly problematiccausepeak tailing

other extra - column frits(passive) caused bypeak tailing

Column packing problemscan causepeak tailing

All threecan causepeak tailing

Preheat ... helpspreventpeak tailing

activity within the GC system and how to take preventative measures to minimize tailing and maximize sensitivity and area reproducibility(passive) caused bypeak tailing

's understandcausespeak tailing

of the mobile phase was adjusted to 3.6 with triethylamine for better resolution andto preventpeak tailing

with which the silica surface may potentially interact with polar and ionisable analytescausingpeak tailing

issuescreateissues

these mountains are out here looking like a snack 😍 # badjoke # explorebc # beautifulbritishcolumbiacausethese mountains are out here looking like a snack 😍 # badjoke # explorebc # beautifulbritishcolumbia

Most of the time(passive) is causedMost of the time

to poor quantitation resultscan leadto poor quantitation results

to decreased sensitivityleadingto decreased sensitivity

from penetration of the analyte molecule deep into the silica matrixresultedfrom penetration of the analyte molecule deep into the silica matrix

from a combination of the programme materialresultingfrom a combination of the programme material

from collection of particles at the inlet fritresultingfrom collection of particles at the inlet frit

to a contamination with lower oligomers that increased with the degree of oligomerization ... and because of increasing contamination with unidentified aliphatic material from the nonpolar solvent and/or columnledto a contamination with lower oligomers that increased with the degree of oligomerization ... and because of increasing contamination with unidentified aliphatic material from the nonpolar solvent and/or column

the area(passive) contributed bythe area

the biscuits(passive) created bythe biscuits

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Smart Reasoning:

C&E

See more*