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Qaagi - Book of Why

Causes

Effects

the other wayto preventbone disease Arthroplasty

a novel mutation ( 78dup27 ) of the TNFRSF11A gene in a Chinese family(passive) caused byPaget 's disease of bone

increased fractures.7 Public health approaches are crucialto preventsymptomatic bone disease

weak bones(passive) caused byVhishashp bone disease

lack of vitamin D(passive) caused bya deforming bone disease

a 27-bp duplication in the TNFRSF11A gene(passive) caused byPaget 's disease of bone

Cavey , J. R. / Structural and functional studies of mutations affecting the UBA domain of SQSTM1 ( p62causePaget 's disease of bone

Academic Article Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic targetto preventmetastatic bone disease

a deficiency of vitamin D or calcium(passive) caused byrkts ) bone disease

https://doi.org/10.1042/BST0320728 Structural and functional studies of mutations affecting the UBA domain of SQSTM1 ( p62causePaget 's disease of bone

Layfield , R , Ciani , B , Ralston , S , Hocking , L , Sheppard , PW , Searle , MS & Cavey , JR 2004 , ' Structural and functional studies of mutations affecting the UBA domain of SQSTM1 ( p62causePaget 's disease of bone

Gordon , J. A. , Lisle , J. W. , Alman , B. A. & Lian , J. B. Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic targetto preventmetastatic bone disease

Actonel Is also usedto preventPaget disease of bone

Select item 1285774515.Structure of the ubiquitin - associated domain of p62 ( SQSTM1 ) and implications for mutationscausePaget 's disease of bone

Hypercalcemia predisposes to extra - osseous calcifications per se , and also through PTH over - suppressioncausingadynamic bone disease

a role in the majority of familial Paget 's disease of bone ... mutationscausePaget 's disease of bone

the serum fluoride levels in patients chronically hemodialyzed with fluoridated water ... thosecausefluorotic bone disease

Paget disease of bone - caused by mutations in the SQSTM1 gene More than 20 mutations in the SQSTM1 gene have been foundto causePaget disease of bone

Increased amounts of fluoride in water ( 1.5 mg / dm3 ) have harmful effects on humans and animalscausingbone disease ( fluorosis

multiple factors and that osteoclasts are particularly important in pain generation through destruction of bone and nerve fibers and acidotic stimulation of pH - sensitive receptors(passive) is caused bymetastatic bone disease

The role of Shp1 in helping plasma cells migrate to the bone marrow suggests possibilities for treating diseases such as multiple myeloma , in which deformed plasma cells accumulate in the bone marrowto causebone - debilitating disease

decreased anaesthetic requirements there is inflammation and potassium ascorbate in the past thirty years extracorporeal therapies designed to create null mutations for both acute and recovery unitscan causebone disease catterson

WebMD AnswerscausesPagets Disease of Bone

accelerated bone turnover and immobilisation of bones(passive) caused bypagets disease of bone

believecauseddisease of the bones

Hormonal diseasescausedisease in the bone

an insertion mutation affecting the RANK signal peptide(passive) caused bydisease of bone

a localized increase in osteoclastic and osteoblastic activity(passive) is caused byPaget disease of bone

increased " bone remodelling " causing symptoms such as pain , deformity , arthritis and deafness(passive) is caused byPaget 's disease of bone

Other bone conditions like Paget ’scan ... causedisease of the bone

that the patient had been ingesting 10 mg of biotin per day for restless leg syndrome(passive) was later discoveredadynamic bone disease

Lowest - afterhad causeddisease of the peti - ous bone

The characteristic bone deformities associated with advanced Paget ’smay resultdisease of bone

The authors ... crucialto preventsymptomatic bone disease

Hypertensioncan causebone disease catterson

which may infect the bone earlier in lifecausingPaget ’s disease of bone

a lack of blood supply to the bone(passive) is caused byA nonneoplastic disease of bone

Paget ’s Disease ( formerly Arthritis Victoria ) - MOVE HomeConditions and Symptoms Paget ’scausesDisease Paget 's disease of bone

calcium deficiency(passive) is caused byMetoblic Bone Disease

to be suspectedto causepaget ’s disease of bone

to an increased risk of fracture in osteoporosisleadsto an increased risk of fracture in osteoporosis

to a decrease in bone density and an increased risk of fractureleadsto a decrease in bone density and an increased risk of fracture

to an increased risk of fracture and is highly common amongst womenleadsto an increased risk of fracture and is highly common amongst women

to an increased risk of fracture because the bone mineral density ( BMD ) is reducedleadsto an increased risk of fracture because the bone mineral density ( BMD ) is reduced

to an increased risk of fracture due to reduced bone density in aging peopleleadingto an increased risk of fracture due to reduced bone density in aging people

to an increased risk of fracture ) as well as deposits of calcium in the soft tissue of the body ( lungs , breasts , kidneysleadsto an increased risk of fracture ) as well as deposits of calcium in the soft tissue of the body ( lungs , breasts , kidneys

your bones to grow too large and weakcausesyour bones to grow too large and weak

your bones to grow larger and weaker than normalcausesyour bones to grow larger and weaker than normal

fatigue and bone paincausingfatigue and bone pain

to complications , such as painleadsto complications , such as pain

significant painis causingsignificant pain

pain and weakens bonestypically causespain and weakens bones

particular vertebral pain(passive) caused byparticular vertebral pain

bone pain , fractures and bone deformitycan causebone pain , fractures and bone deformity

shoulder blade paincan causeshoulder blade pain

pain to the affected areacausingpain to the affected area

severe , progressive pain , and less commonly , pathological fracture , erythema over the affected bone and swellingcausessevere , progressive pain , and less commonly , pathological fracture , erythema over the affected bone and swelling

severe progressive pain and less X - raycausessevere progressive pain and less X - ray

to cancer , which can cause severe painmay rarely leadto cancer , which can cause severe pain

severe , progressive pain , and less commonly , pathological fracture , erythema ( redness ) over the affected bone and swelling [ breast-cancer.cacausessevere , progressive pain , and less commonly , pathological fracture , erythema ( redness ) over the affected bone and swelling [ breast-cancer.ca

pain , swelling , fracture and subsequent dysfunctioncausespain , swelling , fracture and subsequent dysfunction

destructive bone lesions and significant localized paincausesdestructive bone lesions and significant localized pain

intolerable pain and devastatingly impairs ADL in cancer patientsoften causesintolerable pain and devastatingly impairs ADL in cancer patients

oftencausesoften

severe bowling of the legs , poor growth , muscle pain , and weaknesscausessevere bowling of the legs , poor growth , muscle pain , and weakness

affected bones to become enlarged and misshapencausesaffected bones to become enlarged and misshapen

almost constant pain despite the health care team 's best efforts to control itcausedalmost constant pain despite the health care team 's best efforts to control it

in acute or chronic pain , pathological fractures , spinal complications ( with or without neurological complications ) and even spinal cord compressioncan resultin acute or chronic pain , pathological fractures , spinal complications ( with or without neurological complications ) and even spinal cord compression

severe progressive pain and less Persistent indigestion especially accompanied by pain in the stomach or lower abdomen may be signs of various serious medical conditionscausessevere progressive pain and less Persistent indigestion especially accompanied by pain in the stomach or lower abdomen may be signs of various serious medical conditions

abnormal enlargement and weakening of bone Commonly affected bones include the skull , pelvis , spine and the long bones of the arm and thighcausesabnormal enlargement and weakening of bone Commonly affected bones include the skull , pelvis , spine and the long bones of the arm and thigh

to increased risk of broken bones ( fracturesleadsto increased risk of broken bones ( fractures

to a quality of life deterioration in cancer patients and a method that allows a quick pain relief and restoration of a satisfactory function of the affected limbleadto a quality of life deterioration in cancer patients and a method that allows a quick pain relief and restoration of a satisfactory function of the affected limb

not only in fractures , but in pressure on the spinal cord ( spinal cord compression ) , the need for surgery to prevent or repair broken bones , and/or the need for radiation treatments to the bone to control the myeloma and relieve paincan resultnot only in fractures , but in pressure on the spinal cord ( spinal cord compression ) , the need for surgery to prevent or repair broken bones , and/or the need for radiation treatments to the bone to control the myeloma and relieve pain

new bone material to be grown faster and weaker than it normally is , leading to complicationscausesnew bone material to be grown faster and weaker than it normally is , leading to complications

bones to be too densecausesbones to be too dense

bones to fracturecan causebones to fracture

weakness of the bonescausesweakness of the bones

brittle bonescausesbrittle bones

The mechanical problems(passive) caused byThe mechanical problems

some degree of discomfortwill causesome degree of discomfort

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