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Qaagi - Book of Why

Causes

Effects

a prescription medicationmay have contributedto bone ossification

severe pulmonary venous hypertensionmay leadossification of the lung.1011

by a gain of function mutation in the intracellular region of the BMP type I receptor kinase ALK2 , encoded by the gene ACVR1(passive) caused byheterotopic ossification

Activation of Hedgehog signaling by loss of GNAScausesheterotopic ossification

Activation of Hedgehog signaling by loss of GNAScausesheterotopic ossification

Hedgehog signaling by loss of GNAScausesheterotopic ossification

Reference Activation of Hedgehog signaling by loss of GNAScausesheterotopic ossification

may be a part of the regulatory network that controls BMP expressionthereby influencingcranial ossification

ACVR1 / ALK2can causeheterotopic ossification

by a gain of function mutation in the intracellular region of the BMP type(passive) caused byheterotopic ossification

cellscontributeto endochondral ossification

even if the joint growth is due to endochondral ossificationcausesendochondral ossification

Another rare genetic disordercausingheterotopic ossification

ACAN mutations(passive) caused bythe endochondral ossification

tendsto causeheterotopic ossification

materialcausingbioactive ossification

fighting capabilitysetsheterotopic ossification

in vitro(passive) is influencedEndochondral ossification

subperiosteal dissection becauseleaving the periosteum tendsto causeheterotopic ossification

any subperiosteal dissection becauseleaving the periosteum tendsto causeheterotopic ossification

The genecausingthe ossification

The genecausesossification

traumacan causeossification

by defects in Col II secretion(passive) caused byendochondral ossification

The proteincausesossification

by defects in Col II secretion and increased apoptosis(passive) caused byendochondral ossification

defects in Col II secretion and increased apoptosis(passive) caused byendochondral ossification

a previously unrecognized pathwayinfluencingendochondral ossification

the processleadingto ossification

by BMP(passive) caused byOssification

Endochondral ossificationleadingto ossification

s differentiate into chondrocytesleadingto ossification

Mineralization of osteoid forms the new boneresultingin intramembranous ossification

M6 has not been foundto causethe ossification

Inflammatory metaplasialeadingto ossification

to understandcan leadto ossification

by injury(passive) caused byossification

Even minor stretchescan causeossification

a local inflammatory processcontributedto the ossification

An accumulation of the depositsleadsto ossification

to bonyleadingto bony

thoracic myelopathycausingthoracic myelopathy

compression of spinal cord(passive) caused bycompression of spinal cord

the cartilage to form bonewill promptthe cartilage to form bone

in profound hearing loss ( 23invariably resultsin profound hearing loss ( 23

to the formation of the clavicles and cranial bonesleadsto the formation of the clavicles and cranial bones

the cartilagewill promptthe cartilage

in all bonesresultsin all bones

in elongation of the long bones and extension of the axial skeletonresultingin elongation of the long bones and extension of the axial skeleton

in increased heightresultsin increased height

spinal stiffnesscausingspinal stiffness

in axial growthresultingin axial growth

from the extension of a growth of boneresultingfrom the extension of a growth of bone

alsocontributesalso

new bone to grow between vertebrae eventually fusing them together increasing the risk for fracturecausesnew bone to grow between vertebrae eventually fusing them together increasing the risk for fracture

new bone to grow between vertebrae , eventually fusing them together and increasing the risk for fracturecausesnew bone to grow between vertebrae , eventually fusing them together and increasing the risk for fracture

this increase(passive) may have been caused bythis increase

to ankylosisleadingto ankylosis

the trachea(passive) caused bythe trachea

new bone to grow between vertebrae eventually merging them together increasing the risk for fracturecausesnew bone to grow between vertebrae eventually merging them together increasing the risk for fracture

movement restriction affect clinical findings adverselycausesmovement restriction affect clinical findings adversely

new bone to grow between vertebraecausesnew bone to grow between vertebrae

to the peripheral prominences around bonescontributesto the peripheral prominences around bones

Increased tail stiffness(passive) caused byIncreased tail stiffness

The slowing of growth(passive) caused byThe slowing of growth

to osteogenesis in the early stage of MEcontributesto osteogenesis in the early stage of ME

new bone to grow along the ligaments between vertebrae gradually limiting movement and eventually fusing them togethercausesnew bone to grow along the ligaments between vertebrae gradually limiting movement and eventually fusing them together

to the ankylosisleadingto the ankylosis

inflammation in the joints affected , which leads to more paincan also causeinflammation in the joints affected , which leads to more pain

to ankylosis after total hip arthroplastyleadingto ankylosis after total hip arthroplasty

in the formation of bone tissue in an extraskeletal locationcan also resultin the formation of bone tissue in an extraskeletal location

in the formation of bone tissue in an extraskeletal locationmay also resultin the formation of bone tissue in an extraskeletal location

to increased stability of SBMleadingto increased stability of SBM

from certain traumacan resultfrom certain trauma

in a bony foramenresultingin a bony foramen

increased hearing losscausesincreased hearing loss

to the ankylosis so characteristic of this disorderleadingto the ankylosis so characteristic of this disorder

in epiphyseal dysgenesisresultingin epiphyseal dysgenesis

to epiphyseal dysgenesisleadingto epiphyseal dysgenesis

pain and open sores ( ulcersmay causepain and open sores ( ulcers

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