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Lipotoxicity Lipotoxicity ... a metabolic syndromeresultsfrom the accumulation of lipid intermediates in non - adipose tissue ... leading to cellular dysfunction and death
Disruption of ldlrcausesincreased LDL - c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia
VEGF - B signallingleadingto pathological lipid accumulation , overexpansion of fat cells , hypoxia , inflammation and subsequent IR
the 4-h delay in the body temperature surgeledto increased body weight gain and accumulation of lipids in adipose tissues upon DFAM
virus - specific CD8 T cellscausemorphological and molecular changes in adipose tissue leading to depleted lipid stores
frataxin depletionresultedin mitochondrial swelling and lipid droplet accumulation in cardiomyocytes
Impaired cholesterol efflux in rods , but not conesresultin lipid accumulation in RPE and age - associated neuroretinal degeneration
This phenomenon ... fat depotsmay contributeto intrahepatic lipid accumulation and the pathogenesis of NAFLD
These endotoxins can induce latent infection disrupting normal lipid movement through the cell membranecausingaccumulation of lipids leading to metabolic and hepatic steatosis
This deficiencyresultsin accumulation of a metachromatic lipid material , galactosylceramide sulfatide
Accumulation of HBxcan causelipid accumulation in hepatocytes and in HBx - transgenic mice
a deficiency of sulfatase A. Thiscausessulfated lipids to accumulate and cause a condition known as metachomasia
class 5can leadto lipid pneumonia and lipid granuloma
that causes a deficiency of sulfatase A. This in turncausessulfated lipids to accumulate and cause a condition known as metachomasia
that , in GAN fibroblasts , mutations of the GAN gene affect the properties of vimentin IFsleadingto perturbation of lipid metabolism and accumulation of lipid droplets
exposure of human cells to hypoxiacausesaccumulation of triglycerides and lipid droplets
Inhalation , aspiration or ingestion leading to aspiration of white oils and petrolatums suitable for food and medicinal use [ class 5can leadto lipid pneumonia and lipid granuloma
Many mutations in nuclear genes that encode protein components of the translational machinery result in compromised biogenesis of specific or all mitochondrial respiratory chain complexes and lead to decreased OXPHOS and some of these have been shownto causeaccumulation of lipids in hepatocytes
to the imbalance of oxidative stress [ 17 , 18leadingto the imbalance of oxidative stress [ 17 , 18
in improved bone qualityresultedin improved bone quality
higher permeability and susceptibility to the effects of reduced pHcausinghigher permeability and susceptibility to the effects of reduced pH
These Stable Blankets(passive) are also composedThese Stable Blankets
The Pony Stable Blanket(passive) is composedThe Pony Stable Blanket
to the characteristic pathophysiology of ARDSleadingto the characteristic pathophysiology of ARDS
the arteries(passive) caused bythe arteries
tissueshave promptedtissues
to weight gaincould leadto weight gain
to increasedleadto increased
in ferroptotic cell deathresultingin ferroptotic cell death
to the development of NASHleadto the development of NASH
to the development of NASHleadto the development of NASH
alterations in tumor - associated molecular signalingwill causealterations in tumor - associated molecular signaling
almost 70 % of blocked drains , pipes and sewers with significant infrastructure damage following thiscausealmost 70 % of blocked drains , pipes and sewers with significant infrastructure damage following this
in deranged cells that are unable to restore themselvesresultingin deranged cells that are unable to restore themselves
tissuescausetissues
HCCwill causeHCC
that inflammation(passive) caused bythat inflammation
in deranged cells that are unable to restore themselves and function properlyresultingin deranged cells that are unable to restore themselves and function properly
a 60 - 70 % ipsilateral reduction in transcription rate and UCP mRNAcauseda 60 - 70 % ipsilateral reduction in transcription rate and UCP mRNA
to diabetic cardiomyopathythereby contributingto diabetic cardiomyopathy
hepatic steatosis , an emerging liver disease in the US populationcauseshepatic steatosis , an emerging liver disease in the US population
changes(passive) caused bychanges
to acrosome reactioncontributingto acrosome reaction
to fatty liverleadsto fatty liver
to non - alcoholic fatty liver disease ( NAFLD ) , which can progress to non - alcoholic steatohepatitis ( NASH ) and Type 2 diabetes ( T2Dcan leadto non - alcoholic fatty liver disease ( NAFLD ) , which can progress to non - alcoholic steatohepatitis ( NASH ) and Type 2 diabetes ( T2D