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A 5 ' intronic splice site polymorphismleadsto a null allele of the P2X7 gene
some casescausinga null phenotype
in some casescausinga null phenotype
Deletion of the complete P / Q - type channel by the Prm1-Cre recombinaseresultedin a null phenotype
mutations at locus specific primer annealing sites which retard PCR amplification efficiency of particular alleles(passive) caused bynull allele presence
Either of these mechanismswould causea subsequent null allele
zinc finger domains of Mig1134resultingin a null allele Mig188
the targeted modification of the Tbx20 locusresultedin a functional null allele
the gene trap mutationleadsto a null allele
the frameshift mutation ... likelyto resultin a null allele
Several mutations ... are predictedto resultin a null allele
a one base pair deletion introducing a premature STOP codon forleadingto a null allele
A 5 ' intronic splice site polymorphismleadsto a null allele of P2X7
This nonsense mutationcausinga null allele
a nonsense mutationleadingto a null allele
All the mutations were predictedto resultin a null allele
Most of mutations predictedto leadto a null allele
The mutation is predictedto resultin a null allele
this alterationshould resultin a functionally null allele
This large deletion was predictedto resultin a null allele
Mutationsleadingto a null allele
the mutationresultsin a null allele
the mutationresultedin a null allele
Most of the human mutationsresultin a null allele
frameshift mutationsleadingto a null - allele
a splice site , which is also predictedto resultin a null allele
exon 1resultsin a null allele
the size of the productive target region , that is , the portion of the gene within whichleadsto a null allele
by a P - element insertion(passive) caused bya null allele
within whichleadsto a null allele
the insertionresultsin a null allele
the paired domain and frame shift mutationsleadto a null allele
the start codon in exon 1resultsin a null allele
the locusleadingto a null allele
what phenotypeswould resultfrom this null allele
most LIS1 mutationsresultin a null allele
the wpk mutationmay causea null allele
each of these deletionsresultedin a null allele
It is thus predictedto resultin a null allele
a frameshiftresultingin a null allele
in half normal levelsresultsin half normal levels
larval and pupal lethalitycauseslarval and pupal lethality
in embryonic lethalityresultedin embryonic lethality
more embryonic to test red to the ability agescausesmore embryonic to test red to the ability ages
embryonic deathcausedembryonic death
a failure in cell proliferationcausesa failure in cell proliferation
an accumulation of acetaldehydecausesan accumulation of acetaldehyde
in the loss of activity of a generesultsin the loss of activity of a gene
to embryonic lethality when homozygousleadsto embryonic lethality when homozygous
in embryonic lethalityresultin embryonic lethality
an accumulation of acetaldehyde by preventing acetaldehyde's catabolism to acetatecausesan accumulation of acetaldehyde by preventing acetaldehyde's catabolism to acetate
in complete absence of proteinresultingin complete absence of protein
early homozygous - lethality(passive) caused byearly homozygous - lethality
embryonic lethalitycausesembryonic lethality
embryonic lethalitycould causeembryonic lethality
diseasecausedisease
in no mRNA or protein product presentresultingin no mRNA or protein product present
lethalitycauselethality
to a gene productleadingto a gene product
to reduced message or protein levelsleadto reduced message or protein levels
alsomight ... resultalso
in the arrest of embryo developmentresultin the arrest of embryo development
in fatalitywill resultin fatality
loss of functioncauseloss of function
a false excess of homozygousmight causea false excess of homozygous
to BPES phenotypeleadingto BPES phenotype
significant biasdid ... contributesignificant bias
the effects(passive) caused bythe effects
either generated by gene targeting [ 23,24 ] or a frameshift mutationresulteither generated by gene targeting [ 23,24 ] or a frameshift mutation
in non - functional protein productsresultingin non - functional protein products
to absence of AAT1leadingto absence of AAT1
to haploinsufficiencyleadingto haploinsufficiency
in false positivesresultin false positives
to risk of preterm , low birthweight infantscontributesto risk of preterm , low birthweight infants
in no protein productresultsin no protein product
substantial abnormalitiescausedsubstantial abnormalities
early embryonic lethality , whereas mice with an exon 11 deletion can survive at low frequency on a p53 background ( 41causeearly embryonic lethality , whereas mice with an exon 11 deletion can survive at low frequency on a p53 background ( 41
from Mcw2originatingfrom Mcw2
in the loss of some Siglecs ( e.g. , Siglec-12resultingin the loss of some Siglecs ( e.g. , Siglec-12
to lung cancer riskcontributesto lung cancer risk