Loading ...

Blob

Smart Reasoning:

C&E

See more*

Qaagi - Book of Why

Causes

Effects

Abstract : In the search for effective , selective , and nontoxic antiviral and antitumor agents , a variety of strategies have been devisedto designnucleoside analogues

ResearchersdesignedPGF2a analogues

to test the importance of the side - chain features of tryptophan by using a recently developed method for stereoselective fragment religation in yeast cytochrome c. Thermal stability of apolipoprotein A(passive) were designedSemisynthetic analogues

for potent androgen receptor ( AR ) antagonists through rational drug design(passive) was discoveredenzalutamide analogues

by modifying the original chemical structure of a compound — for example , by adding a hydroxyl group(passive) are createdAnalogues

modifying the original chemical structure of a compound to evade detection by the FDA , making the products more difficult to regulate , and to reduce the risk of patent - infringement lawsuits(passive) are created byAnalogues

the thyronine structure ... upon whichto designanalogues

Baldinger Vu - Huu ( winner ) – Episodic Urbanism , by Peter Elliott and contributors , published by Uro Publications , designed by Stuart Geddes – Nicholas Mangan : Limits to Growth , published by Monash University Museum of Art and Sternberg Press , Berlin(passive) designed byAnalogues

to catalyze asymmetric reactions via enamine intermediates with the assistance of tunable hydrogen bonding(passive) have been designedProlinamide analogues

modelled and synthesised which incorporated alternative ' LHS ' fragments linked via either an amide or urea to a privileged ' RHS ' fragment commonly found in CGRP receptor antagonists(passive) were designedAnalogues

to mimic naturally occuring nucleotides(passive) are synthetically createdNucleoside analogues

likelyto causedephosphorylation of monophosphorylated nucleoside analogues

CellMed(passive) discovered byGLP-1 analogues

acid dietary different analogous food readily resistanceledanalogues

to be incorporated into viral nucleic acids and act as chain terminators thus inhibiting efficient viral replication(passive) are designedNucleoside analogues

that are inherently straightforward to synthesise(passive) will be designedAnalogues

synthesizedand characterized.screened for their in - vivo analgesic , anti - pyretic and DNA cleavagestudies(passive) were designedanalogues

as the high affinity niacin receptor G - protein - coupled receptor 109A(passive) were rationally designedTricyclic analogues

using a conformation - based strategy on active core regions(passive) were designedNeuropeptide analogues

Pharmacistshave createdRiboxin analogues

modifying various structural elements of natural nucleic acids(passive) may be created byAnalogues

et lescomposespolycycliques analogues

to closely resemble the naturally occurring nucleoside adenine , one of the essential building blocks of RNA , which carries the virus ’ genetic information(passive) are designedNucleoside analogues

modelled and synthesized(passive) were designedAnalogues

to modulate the binding affinity toward G - actin(passive) were designedAnalogues

BioChem Pharma(passive) discovered bynucleoside analogues

Lignin Non - carbohydrateledanalogues

based on a lead compound that was previously determined to have selective activity as a GPR35 antagonist(passive) were designedAnalogues

replacing the central histidine with substituted pyridinium moieties(passive) were designed byTRH ) analogues

In taking any modern any type of class , course will finddiscoveranalogues

to be potent and selective for p38 , with an emphasis on slow enzyme dissociation kinetics to deliver prolonged lung p38 inhibition(passive) have been designedAnalogues

as derivatives of eitherthe biaryl(passive) were designedAnalogues

the loss or depletion of nucleoside kinases(passive) caused bynucleoside analogues

of n = 5 - 15 phenol subunits [ 56(passive) are composedanalogues

modeling was usedto designanalogues

adding methyl groups in the ester side chain elongating the length to form ethyl , isopropyl , sec - butyl and neo - pentyl acetates(passive) were created byAnalogues

Side Chains / TerminalsCreatingAnalogues

taking Imatinib as a prototype(passive) have been designed byAnalogues

GT110507to leadtacrolimus analogues

to investigate the effects of modification of these factors on antimicrobial activities ( Table1(passive) were designedAnalogues

to treat hepatitis C virus ( HCV ) infections and potentially other diseasesdesignedto treat hepatitis C virus ( HCV ) infections and potentially other diseases

for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase Bioorganic and Medicinal Chemistrydesignedfor selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase Bioorganic and Medicinal Chemistry

mitochondrial toxicity to varying degreesmay causemitochondrial toxicity to varying degrees

to combine the most favorable pharmacokinetic properties of fludarabine and cladribinedesignedto combine the most favorable pharmacokinetic properties of fludarabine and cladribine

the hormonal - induced activation of nuclear receptors such as MR and also GR by inducing their degradation via the ubiquitin - proteasome system [ 6 ] , [ 7 ] , [ 8preventthe hormonal - induced activation of nuclear receptors such as MR and also GR by inducing their degradation via the ubiquitin - proteasome system [ 6 ] , [ 7 ] , [ 8

to full restoration of the barrier function of the skinare contributingto full restoration of the barrier function of the skin

using both acyclic and cyclic templatesdesignedusing both acyclic and cyclic templates

using both acyclic and cyclic ovenightdesignedusing both acyclic and cyclic ovenight

to support drug discovery and development researchdesignedto support drug discovery and development research

to treat hepatitis C virus ( HCV ) infections , licensed to Boehringer Ingelheim , and a series of candidate drugs aimed at treatment of respiratory syncytial virus ( RSV ) diseasedesignedto treat hepatitis C virus ( HCV ) infections , licensed to Boehringer Ingelheim , and a series of candidate drugs aimed at treatment of respiratory syncytial virus ( RSV ) disease

for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase 2000 10.1016 / s0968 - 0896(00)00051 - 1 10882019 http://vivo.scripps.edu/individual/endnote193708designedfor selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase 2000 10.1016 / s0968 - 0896(00)00051 - 1 10882019 http://vivo.scripps.edu/individual/endnote193708

more weight loss ( Table ) and gastrointestinal side effects than controls ( nausea , relative risk increase [ RRI ] 192 % , 95 % CI 102 to 324 ; vomiting , RRI 232 % , CI 151 to 341 ; and diarrhea , RRI 123 % , CI 72 to 189causedmore weight loss ( Table ) and gastrointestinal side effects than controls ( nausea , relative risk increase [ RRI ] 192 % , 95 % CI 102 to 324 ; vomiting , RRI 232 % , CI 151 to 341 ; and diarrhea , RRI 123 % , CI 72 to 189

neuropathy exert direct mitochondrial toxicity that is not mediated indirectly through the inhibition of DNA polymerase - γcauseneuropathy exert direct mitochondrial toxicity that is not mediated indirectly through the inhibition of DNA polymerase - γ

liver injury by several mechanismscan causeliver injury by several mechanisms

to 9-deazaxanthine derivatives as dual A(2A ) antagonists / MAO - B inhibitorsleadingto 9-deazaxanthine derivatives as dual A(2A ) antagonists / MAO - B inhibitors

the immune outcome of glycolipid administration ... particularly to improve the clinical efficacy of CD1d - binding glycolipidsinfluencethe immune outcome of glycolipid administration ... particularly to improve the clinical efficacy of CD1d - binding glycolipids

from substitution of amino acids with similar chemical characteristics to the originalresultingfrom substitution of amino acids with similar chemical characteristics to the original

and synthesized based on structure - activity relationships and molecular modeling ... 18 , 21 , 22 , 26 , 31 , 34have been designedand synthesized based on structure - activity relationships and molecular modeling ... 18 , 21 , 22 , 26 , 31 , 34

a testosterone spike in the first few weeks of usagetriggera testosterone spike in the first few weeks of usage

less adrenocortical suppression ETOMIDATE is a potent and rapidly acting imidazole - based anesthetic agent that is highly valued for its minimal effects on breathing and blood pressure andcauseless adrenocortical suppression ETOMIDATE is a potent and rapidly acting imidazole - based anesthetic agent that is highly valued for its minimal effects on breathing and blood pressure and

decades ago but never put into legitimate usediscovereddecades ago but never put into legitimate use

a small increase in cell deaths in the first minutes of each experiment , followed by relative sparing from further neurodegenerationcauseda small increase in cell deaths in the first minutes of each experiment , followed by relative sparing from further neurodegeneration

largely on the basis of the crystal structure of the stable “ frozen ” TS analogues or the “ still ” TS structures from the kinetic studiesare designedlargely on the basis of the crystal structure of the stable “ frozen ” TS analogues or the “ still ” TS structures from the kinetic studies

dollars of life coming online structure ... a size between quantum and right , and the Press of composite strategies of another without polychronic members ... although not identifies the spacetime in examples not seek philosophical relationships in these physicists within this welfare Koski and Sterck , 2009contributedollars of life coming online structure ... a size between quantum and right , and the Press of composite strategies of another without polychronic members ... although not identifies the spacetime in examples not seek philosophical relationships in these physicists within this welfare Koski and Sterck , 2009

as metabolically stable surrogates of the natural nucleosidesdesignedas metabolically stable surrogates of the natural nucleosides

to more closely mimic Raloxifenedesignedto more closely mimic Raloxifene

to overcome AAC(6′)s and strategies for blocking AAC(6′)sdesignedto overcome AAC(6′)s and strategies for blocking AAC(6′)s

of alternative backbone structures containing internucleotide linkages such as methylphosphonate , phosphotriester , phosphorothioate , peptide , and the likecomposedof alternative backbone structures containing internucleotide linkages such as methylphosphonate , phosphotriester , phosphorothioate , peptide , and the like

from supplementation of AHBA analogueresultingfrom supplementation of AHBA analogue

mitochondrial perform to your variable diploma , which can be most pronounced with stavudine , didanosine and zidovudinemay influencemitochondrial perform to your variable diploma , which can be most pronounced with stavudine , didanosine and zidovudine

to act as inhibitory competitors of viral polymerasesdesignedto act as inhibitory competitors of viral polymerases

to mimic both the methyl donor S - adenosylmethionine ( AdoMetdesignedto mimic both the methyl donor S - adenosylmethionine ( AdoMet

sometimescan ... causesometimes

to act as competitive alternative substrate inhibitors of virally encoded polymerasesdesignedto act as competitive alternative substrate inhibitors of virally encoded polymerases

Akt translocation , 389IL-4 cytotoxin , xenograft models , 245 in vivopreventAkt translocation , 389IL-4 cytotoxin , xenograft models , 245 in vivo

to mimic the structures of the natural building blocks of DNA and RNAdesignedto mimic the structures of the natural building blocks of DNA and RNA

recurrence of hepatitis B virus ( HBV ) infectioncan preventrecurrence of hepatitis B virus ( HBV ) infection

Akt translocation , 389novel xenograft model for human FAP expression , 729PXD101 , a novel HDAC inhibitor , 721role of PKC δ , 273Trx-1 inhibitors PX-12 and pleurotin , 235MCF7preventAkt translocation , 389novel xenograft model for human FAP expression , 729PXD101 , a novel HDAC inhibitor , 721role of PKC δ , 273Trx-1 inhibitors PX-12 and pleurotin , 235MCF7

and synthesized and tested for their anti - epileptic activitywere designedand synthesized and tested for their anti - epileptic activity

above with known affinity for the regulator proteindesignedabove with known affinity for the regulator protein

Blob

Smart Reasoning:

C&E

See more*