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Qaagi - Book of Why

Causes

Effects

by an interaction in which excessive glutamatergic or " excitotoxic " tone modifies(passive) is caused byDA neuronal degeneration

by an interaction in which excessive glutamatergic or " excitotoxic " tone modifies(passive) is causedDA neuronal degeneration

by an interaction in which excessive glutamatergic or " " " " " " " " excitotoxic " " " " " " " " tone modifies ASyn properties and function through nitric oxide(passive) is caused byDA neuronal degeneration

by an interaction in which excessive glutamatergic or " " " " " " " " excitotoxic " " " " " " " " tone modifies ASyn properties and function through nitric oxide(passive) is causedDA neuronal degeneration

an interaction in which excessive glutamatergic or " " " " " " " " excitotoxic " " " " " " " " tone modifies ASyn properties and function through nitric oxide(passive) is caused byDA neuronal degeneration

by the disease results from excess free - radicals oxidation or glutamate(passive) caused bythe neuronal degeneration

by said condition , disorder or disease associated with the eye(passive) caused byneuronal degeneration

by the disease , disorder or condition(passive) caused bythe neuronal degeneration

protein accumulation ... neuronal toxicitycausesneuronal degeneration

inflammation in glial cellscausedneuronal degeneration

by brain amyloid beta ( A ? ) plaques or hyperphosphorylated forms of the protein(passive) caused byneuronal degeneration

by the neurodegenerative effects of disease(passive) caused byneuronal degeneration

lysosomal function ... which in turn is thoughtto causeneuronal degeneration

by chronic oxidative stress(passive) caused byneuronal degeneration

free radical metabolism , and impaired mitochondrial function ... both of whichcontributeto neuronal degeneration

Alzheimer?s disease ... the braincausesneuronal degeneration

noise exposure(passive) caused bycochlear neural degeneration

by brain amyloid beta ( A(passive) caused byneuronal degeneration

by brain amyloid beta(passive) caused byneuronal degeneration

The diseasecausesneuronal degeneration

by the disease(passive) caused bythe neuronal degeneration

the disease(passive) caused bythe neuronal degeneration

where an increased A peptide production and accumulation is believedto causeneuronal degeneration

mutations in essential genescauseneuronal degeneration

free radical and mitochondrial damagecan leadto neuronal degeneration

Alzheimers disease ... the braincausesneuronal degeneration

an accumulation of glutamatecontributesto neuronal degeneration

molecular processescausingneuronal degeneration

Deficiency of coppercan causeneuronal degeneration

by excitotoxicity , or over - stimulation of the neurons(passive) to be primarily caused byNeuronal degeneration

excitotoxicity , or over - stimulation of the neurons(passive) to be primarily caused byNeuronal degeneration

A protein in the brain parenchymacausingneuronal degeneration

Insufficient dopaminergic activity due tocontributesneuronal degeneration

by Huntington 's disease (passive) caused byneuronal degeneration

mutationscausingneuronal degeneration

Mutant huntingtin is thoughtto causeneuronal degeneration

by the genetic mutations that lead to Huntington 's disease(passive) caused byneuronal degeneration

by inflammation(passive) caused bythe neuronal degeneration

the mechanismscausingneuronal degeneration

Deposition of A protein in the brain parenchymacausingneuronal degeneration

deathto causedeath

to muscular atrophy , weakness and ultimately deathleadsto muscular atrophy , weakness and ultimately death

in severe disabilityresultsin severe disability

the spongiform appearance in the affected braincausesthe spongiform appearance in the affected brain

the spongiform appearance in the affected brain.[12causesthe spongiform appearance in the affected brain.[12

the spongiform appearance in the affected brain.[11causesthe spongiform appearance in the affected brain.[11

the spongiform appearance in the affected brain.[9causesthe spongiform appearance in the affected brain.[9

the spongiform appearance in the affected brain.[14causesthe spongiform appearance in the affected brain.[14

the spongiform appearance in the affected brain.[15causesthe spongiform appearance in the affected brain.[15

to loss of control of body movementsleadsto loss of control of body movements

to blurred visionwill leadto blurred vision

a shortage of dopaminecausinga shortage of dopamine

typicallycausestypically

progressive damage resulting in loss of central vision without affecting your peripheral visioncausesprogressive damage resulting in loss of central vision without affecting your peripheral vision

generallywill ... causegenerally

from a partial breakdown of cells within the retinaresultsfrom a partial breakdown of cells within the retina

to ataxia and deathleadingto ataxia and death

to nervecan leadto nerve

from demyelination or Wallerian degenerationpossibly resultingfrom demyelination or Wallerian degeneration

to the development of motor symptomsleadingto the development of motor symptoms

in disorders in fine movement , posture , and motor learning in humanscan resultin disorders in fine movement , posture , and motor learning in humans

to the patients deathmay leadto the patients death

various motor deficitscausingvarious motor deficits

the symptoms of Parkinson 's diseasecausesthe symptoms of Parkinson 's disease

the disease(passive) caused bythe disease

These changesleadThese changes

neuronal cell deathcausesneuronal cell death

various motorcausingvarious motor

to ataxia , paralysis , andledto ataxia , paralysis , and

to dementialeadingto dementia

widespread cerebral atrophy , or brain shrinkage(passive) caused bywidespread cerebral atrophy , or brain shrinkage

to the cognitive impairment and deathleadsto the cognitive impairment and death

diseases(passive) caused bydiseases

in myelin damagewill resultin myelin damage

characteristic symptomscausescharacteristic symptoms

to Parkinson 's disease ( PDleadingto Parkinson 's disease ( PD

the symptoms of " Alzheimers disease " , Parkinsons and dementia(passive) are caused bythe symptoms of " Alzheimers disease " , Parkinsons and dementia

to ALSleadingto ALS

Parkinson 's diseasecausesParkinson 's disease

eventuallycauseseventually

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