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Qaagi - Book of Why

Causes

Effects

glutamate excitotoxicitycausesneuronal cell death 10.3.2.8

Núñez G. bcl - x is expressed in embryonic and postnatal neural tissues and functionsto preventneuronal cell death

811 - 3 , 1995 González - García , García , Ding , OShea , Boise , Thompson , Núñez : " bcl - x is expressed in embryonic and postnatal neural tissues and functionsto preventneuronal cell death

Excitotoxicity , the effect of glutamate receptor activationto triggerneuronal cell death

the ability of a compoundto preventneuronal cell death

J Clin Microbiol ( 1995 ) 1.47 bcl - x is expressed in embryonic and postnatal neural tissues and functionsto preventneuronal cell death

different mechanisms by whichcan causeneuronal cell death

excessive activation of glutamate receptors ... increased intracellular calciumtriggersneuronal cell death

Excessive glutamatecausesneuronal cell death

glutamate , NMDA , and(passive) caused byneuronal cell death

understanding the mechanisms used by NRG1to preventneuronal cell death

distinct mechanisms in different neurodegenerative diseases(passive) are caused byneuronal cell death

Several neurodegenerative diseasescan causeneural cell death

over - activation of glutamate receptors [ 1,2(passive) caused byneuronal cell death

overstimulation of glutamate receptors(passive) caused byneuronal cell death

over - stimulation of the glutamate receptors(passive) caused byneuronal cell death

Abstract ] negative regulation of endoplasmic reticulum stress - induced intrinsic apoptotic signaling pathway Source : UniProtKB " bcl - x is expressed in embryonic and postnatal neural tissues and functionsto preventneuronal cell death

Overactivation of glutamate receptors leads to calcium overloadingtriggeringneuronal cell death

the three types of SOD1 mutant genes ( FIG(passive) caused byneuronal cell death

transient brain ischemia(passive) caused byneuronal cell death

the ability of glutamate receptor activationto triggerneuronal cell death

toxic levels of glutamate and is useful in strokes and epilepsy(passive) caused byneuronal cell death

an excessive production and accumulation of reactive oxygen species ( ROS(passive) is caused byneuronal cell death

It has also shown protection against excitotoxicitythereby preventingneuronal cell death

excitatory neurotransmitters such as glutamate(passive) caused byneuronal cell death

decreased uptake of glutamatecausesneuronal cell death

imbalanced levels of glutamate(passive) caused byneuronal cell death

excessive amounts of glutamatecan triggerneuronal cell death

an excess of glutamate ( 5(passive) caused byneuronal cell death

excessive activation of glutamate receptors due to increasing levels of extracellular glutamate at the lesion site(passive) caused byneuronal cell death

ischemia or other events knownto causeneuronal cell death

the identified mechanism ... neurodegenerative diseases and injurycauseneuronal cell death

Elliott Mufson on Gambogic amide , a selective agonist for TrkA receptor that possesses robust neurotrophic activitypreventsneuronal cell death

Ye K. Gambogic amide , a selective agonist for TrkA receptor that possesses robust neurotrophic activitypreventsneuronal cell death

toxic levels of glutamate which is associated with Alzheimer 's disease(passive) caused byneuronal cell death

toxic levels of glutamate , which makes it useful in strokes and epilepsy too(passive) caused byneuronal cell death

glutamate efflux under ischemic conditions(passive) caused byneuronal cell death

several reasons like glutamate toxicity [ 110(passive) caused bythe neuronal cell death

glutamate toxicity and inhibits an enzyme that degrades the SHOP(passive) caused byneuronal cell death

chemotherapeutic agents(passive) caused byneuronal cell death

to Alzheimer ’s disease and dementialeadsto Alzheimer ’s disease and dementia

The dementia of Alzheimer 's disease(passive) is caused byThe dementia of Alzheimer 's disease

to neurodegenerative diseases such as Parkinson 's disease and Alzheimer 's diseaseleadingto neurodegenerative diseases such as Parkinson 's disease and Alzheimer 's disease

to Alzheimer 's disease Findingsleadingto Alzheimer 's disease Findings

to Alzheimer 's disease | EurekAlertleadingto Alzheimer 's disease | EurekAlert

to Alzheimer 's disease ( ADleadingto Alzheimer 's disease ( AD

to neurodegenerative diseases and most commonly Alzheimer 's diseaseleadingto neurodegenerative diseases and most commonly Alzheimer 's disease

to Alzheimer 's disease , dementia , and neural degenerationleadsto Alzheimer 's disease , dementia , and neural degeneration

to progressive dementialeadingto progressive dementia

Parkinson 's disease ( PD(passive) is caused byParkinson 's disease ( PD

significantly to ischemic brain injurycontributedsignificantly to ischemic brain injury

to neurodegenerative diseases and most commonly Alzheimer ’s disease [ 6 , 9leadingto neurodegenerative diseases and most commonly Alzheimer ’s disease [ 6 , 9

the death of injured brain cells - Progesteronepreventsthe death of injured brain cells - Progesterone

nervous system disorders including Parkinson 's disease and Alzheimer 's diseasecan causenervous system disorders including Parkinson 's disease and Alzheimer 's disease

Parkinson ’s disease , like trichloroethylene and perchloroethylenecauseParkinson ’s disease , like trichloroethylene and perchloroethylene

to the debilitating symptoms associated with diseases like Parkinson ’s and Alzheimerleadsto the debilitating symptoms associated with diseases like Parkinson ’s and Alzheimer

autosomal - dominant familial Alzheimer 's disease ( FADcausingautosomal - dominant familial Alzheimer 's disease ( FAD

to edema , hemorrhage , and necrosis when encephalitis is presentleadingto edema , hemorrhage , and necrosis when encephalitis is present

to the progressive mental decline in both Down syndrome and Alzheimer diseasecontributesto the progressive mental decline in both Down syndrome and Alzheimer disease

from stroke , seizures , and other age - related diseases.(8 , 9 ) Oroxylin A ... also from Chinese skullcapresultsfrom stroke , seizures , and other age - related diseases.(8 , 9 ) Oroxylin A ... also from Chinese skullcap

to dementia , which would be similar to alzheimers diseasecould leadto dementia , which would be similar to alzheimers disease

to degenerative brain diseaseswill leadto degenerative brain diseases

to Alzheimer ’s Disease ... using a very simple compound that blocks free radicals and inflammationleadsto Alzheimer ’s Disease ... using a very simple compound that blocks free radicals and inflammation

brain atrophy(passive) caused bybrain atrophy

to increased inflammation through the activation of astrocytes and microglialeadsto increased inflammation through the activation of astrocytes and microglia

from ischemic insult such as from a cerebral strokeresultingfrom ischemic insult such as from a cerebral stroke

to Alzheimer 's diseaseMemantineleadingto Alzheimer 's diseaseMemantine

under the same conditions as autophagy[30 ... essentially leading to the destruction of cancer cellscan be triggeredunder the same conditions as autophagy[30 ... essentially leading to the destruction of cancer cells

to the progressive infarct development and associated functional impairments after cerebral ischemia or brain traumacontributesto the progressive infarct development and associated functional impairments after cerebral ischemia or brain trauma

to Alzheimers disease 11leadingto Alzheimers disease 11

from either acute insults due to ischemia , trauma , excitotoxicity , or chronic neurodegenerative diseasesresultingfrom either acute insults due to ischemia , trauma , excitotoxicity , or chronic neurodegenerative diseases

inflammation and BCP treatmentcould triggerinflammation and BCP treatment

from oxidative stress , inflammation , and failure of the blood brain barrierresultingfrom oxidative stress , inflammation , and failure of the blood brain barrier

to dopamine deficiency Defective gene for  synuclein on Chrleadingto dopamine deficiency Defective gene for  synuclein on Chr

to Alzheimer 's diseaseGlaucoma treatment timeleadingto Alzheimer 's diseaseGlaucoma treatment time

from early necrosis or delayed apoptosisresultingfrom early necrosis or delayed apoptosis

a gradual and progressive neurodegenerative disease(passive) caused bya gradual and progressive neurodegenerative disease

AbstractParkinson 's disease ( PD(passive) is caused byAbstractParkinson 's disease ( PD

memory loss and other deficiencies in brain functioncausesmemory loss and other deficiencies in brain function

from ischemic insult or from acute damage , such as traumatic brain injury , associated with glutamate - induced neuronal excitotoxicity , or for treating type 2 diabetes in a patient or preventing type 2 diabetes in a subject , as well as in identifying inhibitors of GSK-3resultingfrom ischemic insult or from acute damage , such as traumatic brain injury , associated with glutamate - induced neuronal excitotoxicity , or for treating type 2 diabetes in a patient or preventing type 2 diabetes in a subject , as well as in identifying inhibitors of GSK-3

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