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Qaagi - Book of Why

Causes

Effects

how these plaques and tangles form andleadto neuron death

ROS ... eventsleadto neuron death

different mechanismscontributeto dopaminergic neuron death

brain oxidative stresspreventsneuron death

overexpression of glutamateresultingin neuron death

 True or False Neurofibrillary tanglescauseneuron death

Their research interest ... mechanismsleadto neuron death

different cellular mechanismscontributeto dopaminergic neuron death

All these mechanisms ’ acting synergycan causeneuron death

These so - called ischemic cascade eventscontributeto neuron death

MSO ... a toxic cascade of eventscan leadto neuron death

Glutamate ... the processleadsto neuron death

plagues and tangles ... the brainleadto neuron death

Most neurodegenerative diseases ... which are thoughtto causeneuron death

H2O2-induced oxidative stress(passive) caused byneuron death

The search for chemical compoundsto preventneuron death

the ability of Compound Ato preventexcitotoxic neuron death

amyloid beta to aggregatecan leadto neuron death

With reduction in Akt activity , GSK3β hyper - phosphorylates [ 154 ] , triggering tau accumulation in the brain , which further instigates the generation of neurofibrillary tangles ( NFTs ) ,ultimately causingneuron death

degenerative neurological diseases , brain injuries , or lifestyle factorscontributeto neuron death

supporting cells ... in certain conditions of brain injurycan causeneuron death

the accumulation of beta - amyloid plaques which are toxic to neurons(passive) is caused byNeuron death

The interfibrillary tangles and amyloid plaques ... thoughtto contributeto neuron death

the exact mechanism by whichcausesneuron death

The precise mechanism by whichmight causeneuron death

other factors , possibly in coordination with oxidative stresscontributeto neuron death

miscommunication between cells ... neurodegenerative diseasesresultsin neuron death

NMDA receptor overactivation in a patient(passive) is caused byneuron death

tangles of tau proteinsleadto neuron death

beta - amyloid and other neurotoxins(passive) caused byneuron death

the beta - amyloid proteinscontributeto neuron death

treatment with amyloid - beta(passive) caused bydeath of neuron

transient global ischemia , or excitotoxicity in vitro(passive) caused byneuron death

activity of a genecan leadto neuron death

the build up proteincausingneuron death

the inflammatory processleadingto neuron death

that amyloid ... the processleadsto neuron death

therefore suffer from MN excitotoxicity because of their low threshold of activationresultingin neuron death

the brain floods with glutamatecausesneuron death

DNA damage and defects in the pathways involved in DNA repaircan resultin neuron death

Alzheimer 's(passive) is caused byAlzheimer 's

from necrotic and apoptotic insults Lee , A. L. , Dumas , T. C. , Tarapore , P. E. , Webster , B. R. , Ho , D. Y. , Kaufer , D. , Sapolsky , R. M. 2003 ; 86 ( 5resultingfrom necrotic and apoptotic insults Lee , A. L. , Dumas , T. C. , Tarapore , P. E. , Webster , B. R. , Ho , D. Y. , Kaufer , D. , Sapolsky , R. M. 2003 ; 86 ( 5

to Alzheimer ’s disease or Parkinson ’s diseasecould contributeto Alzheimer ’s disease or Parkinson ’s disease

to diseases such as Alzheimer , Parkinson ’s etcleadsto diseases such as Alzheimer , Parkinson ’s etc

in Alzheimer ’s , which lettuce is great for preventingcan resultin Alzheimer ’s , which lettuce is great for preventing

brain disorders(passive) caused bybrain disorders

to a number of neurological disordersleadsto a number of neurological disorders

from necrotic and apoptotic insults JOURNAL OF NEUROCHEMISTRY Lee , A. L. , Dumas , T. C.resultingfrom necrotic and apoptotic insults JOURNAL OF NEUROCHEMISTRY Lee , A. L. , Dumas , T. C.

Alzheimer ’s ... the proliferation of senile plaques ( deposits of beta - amyloid peptide ) and the formation of structures called amyloid fibrils(passive) is caused byAlzheimer ’s ... the proliferation of senile plaques ( deposits of beta - amyloid peptide ) and the formation of structures called amyloid fibrils

in the brain 's inability to initiate or control muscle movementresultingin the brain 's inability to initiate or control muscle movement

Many other neurodegenerative diseases(passive) are caused byMany other neurodegenerative diseases

to motor function lossleadsto motor function loss

to the iriflarnmatory cascadecontributesto the iriflarnmatory cascade

to memory loss and progressive cognitive declineleadingto memory loss and progressive cognitive decline

to a cavityleadsto a cavity

the birth of other neurons ... but only for certain cells that have the phoenixlike ability to replace their neighborscan triggerthe birth of other neurons ... but only for certain cells that have the phoenixlike ability to replace their neighbors

to senile dementiawill finally leadto senile dementia

by whatever mechanismcontributesby whatever mechanism

to this devastating diseaseleadingto this devastating disease

to brain deathleadingto brain death

memory loss and even dementiacan causememory loss and even dementia

neurological dysfunction(passive) caused byneurological dysfunction

White matter damage ( WMD ) and(passive) may be causedWhite matter damage ( WMD ) and

the progressive vision loss characteristic of diabetic retinopathy and results in 12,000 to 24,000 new cases of blindness each year in the U.S.causesthe progressive vision loss characteristic of diabetic retinopathy and results in 12,000 to 24,000 new cases of blindness each year in the U.S.

a decrease in the size of the hippocampus and overall brain size Loss of hippocampus size is associated with lower scores on memory tests Hippocampus Volume adjusted ( cm 3causesa decrease in the size of the hippocampus and overall brain size Loss of hippocampus size is associated with lower scores on memory tests Hippocampus Volume adjusted ( cm 3

to the onset of the diabetic neuropathy pathology [ 39 , 40contributesto the onset of the diabetic neuropathy pathology [ 39 , 40

inefficiency of the major bodily organs ... especially of the respiratory system with death occurring as early as within weeks in the of deathcausesinefficiency of the major bodily organs ... especially of the respiratory system with death occurring as early as within weeks in the of death

dopamine production(passive) caused bydopamine production

loss of dopamine which causes PDcausesloss of dopamine which causes PD

to the breakdown of memory and communication between parts of the brainleadsto the breakdown of memory and communication between parts of the brain

the glial reaction(passive) triggered bythe glial reaction

in hypoglycemia in children with type 1 diabetescausedin hypoglycemia in children with type 1 diabetes

This selective motor(passive) can be preventedThis selective motor

to denervation of axonsleadingto denervation of axons

to PD and to identify genes that increase susceptibility or resistance to the PD - inducing effects of toxinsleadingto PD and to identify genes that increase susceptibility or resistance to the PD - inducing effects of toxins

from activation of both apoptotic and non - apoptotic pathwaysresultingfrom activation of both apoptotic and non - apoptotic pathways

to Synapse Rearrangement training behind themLeadsto Synapse Rearrangement training behind them

in vivo by the absence of the pro - apoptotic protein Bax , target tissue innervation abnormalities persist in the absence of Egr3is preventedin vivo by the absence of the pro - apoptotic protein Bax , target tissue innervation abnormalities persist in the absence of Egr3

with bone marrow - derived MSCs(passive) was preventedwith bone marrow - derived MSCs

problems with thinking and reasoning in relation to the selfmay causeproblems with thinking and reasoning in relation to the self

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Smart Reasoning:

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