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Hypoxiacausedsignificant neuron death
Injury to the central nervous system including brain and spinal cordcausesneuron death and demyelination
a chemical lesioncausingsubstantial neuron death
inhibition of mitochondrial complex I activity ... sufficientto causedopaminergic neuron death
free radicals(passive) caused byaccelerated neuron death
I activity ... sufficientto causedopaminergic neuron death
different cellular mechanismscontributeto dopaminergic neuron death
turnleadingto dopaminergic neuron death
in turnleadsto dopaminergic neuron death
The loss of the PINK1 protein ... mitochondrial dysfunctioncausesdopaminergic neuron death
Oxidative stress ... the main factor of this diseasecausesdeath of neurons
free radicalscauseneurons death
mitochondrial dysfunctioncausesdopaminergic neuron death
by amyloid beta formation(passive) caused byneurons death
by MPTP(passive) caused bydopaminergic neuron death
by MPTP , a neurotoxin(passive) caused bydopaminergic neuron death
activation of microglia could trigger neuroinflammationleadingto dopaminergic neuron death
different mechanismscontributeto dopaminergic neuron death
cells ... sufficientto causeexcitotoxic neuron death
that activation of the MEKK - JNK pathwaycausessympathetic neuron death
the cell bodyleadingto neuron death
by K+(passive) caused byGranule neuron death
eventscausingneuron death
eventsleadto neuron death
the braincontributeto neuron death
the braincould leadto neuron death
toxic cellular inflammationresultingin neuron death
the diseaseleadsto neuron death
The above damages are knownto causeneuron death
activity of a genecan leadto neuron death
the activity of a genecan leadto neuron death
At the same time , increased intracellular calcium causes the disorder of calcium homeostasisresultingin neuron death
signs of damage ... in turnleadsto neuron death
One hypothesis ... neuronsleadsto neuron death
One hypothesis ... neuronsleadsto neuron death
Glutamate toxicity Glutamate ... the processleadsto neuron death
AD ... the braincontributeto neuron death
cellscausingneuron death
Over timemay ... leadto neuron death
Over timemay ... leadto neuron death
hippocampus - dependent memory deficitscan causehippocampus - dependent memory deficits
to this movement disorderleadto this movement disorder
The decline of dopamine concentration(passive) caused byThe decline of dopamine concentration
to functional declineleadsto functional decline
brain damagecausingbrain damage
brain damagethus causingbrain damage
irreversiblecausesirreversible
Alzheimers diseasecausesAlzheimers disease
from neurodegenerative diseasesresultedfrom neurodegenerative diseases
a common neurodegenerative motor disorder(passive) caused bya common neurodegenerative motor disorder
from agents that disrupt lysosomeresultingfrom agents that disrupt lysosome
to denervation of axons ... at this stageleadingto denervation of axons ... at this stage
to denervation of axonsleadingto denervation of axons
to paralysis or other complicationsleadsto paralysis or other complications
to brain deathleadingto brain death
to the brain?s inability to initiate or control muscles motionleadingto the brain?s inability to initiate or control muscles motion
This condition ... deposition of amyloid , acetylcholine(passive) may be caused byThis condition ... deposition of amyloid , acetylcholine
to irreversible disability for patientsleadsto irreversible disability for patients
the decrease in dopamine production(passive) caused bythe decrease in dopamine production
to irreversible disability in patients with MSleadsto irreversible disability in patients with MS
in the brain?s inabilityresultingin the brain?s inability
memory loss and even dementiacan causememory loss and even dementia
to depressionleadsto depression
to such symptoms in the first placeleadsto such symptoms in the first place
dopamine production(passive) caused bydopamine production
potential alterations in neuronal function(passive) are ... causedpotential alterations in neuronal function
to this devastating diseaseleadingto this devastating disease
a syndrome(passive) caused bya syndrome
in serious disability and ... in some cases ... even deathmay resultin serious disability and ... in some cases ... even death
the problemcausesthe problem
neurological dysfunction(passive) caused byneurological dysfunction
from an injury or strokeresultingfrom an injury or stroke
Alzheimer 's(passive) is caused byAlzheimer 's
over stimulationcausedover stimulation
by over stimulationcausedby over stimulation
in loss of memorymay resultin loss of memory
in the brain?s inability to initiate or control muscle movementresultingin the brain?s inability to initiate or control muscle movement
to Alzheimer?s disease or Parkinson?s diseasecould contributeto Alzheimer?s disease or Parkinson?s disease
brain disorders(passive) caused bybrain disorders
the muscles under their control to weaken and waste away leading to paralysiscausesthe muscles under their control to weaken and waste away leading to paralysis