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Qaagi - Book of Why

Causes

Effects

an error in cell division very early in the development of the unborn baby(passive) is caused byMosaicism

postzygotic mutation(passive) caused bymosaicism

PreventionThere ... no known wayto preventmosaicism

somatic mutations or other processes(passive) may be caused byMosaicism

lyonization ( X - inactivation(passive) caused bymosaicism

chromosome nondisjunction(passive) caused byMosaicism

gene ... tryingto preventmosaicism

The disorder results from a mutation in the AKT1 gene ( which regulates cell growth ) ,causingmosaicism

when a mutation arises early in development(passive) is causedMosaicism

when nondisjunction occurs during mitotic division in the zygote after the fertilization(passive) is causedMosaicism

a mutation in TSC1 or TSC2 in a NC cell during embryonic development(passive) caused bymosaicism

Moreover mechanisms including meiotic non - disjunction and anaphase lag are reportedto causemosaicism

a genetic mutation of the NF1 gene that arises after conception and during early embryonic development(passive) is caused byMosaicism

postzygotic mitotic nondisjunction in somatic tissue rather than the meiotic nondisjunction seen binary options(passive) is caused byMosaicism

postzygotic mitotic nondisjunction in somatic tissue rather than the meiotic nondisjunction seen in the germ cell line that results in aneuploidy(passive) is caused byMosaicism

an error in mitosis(passive) may be caused byMosaicism

shock metamorphism(passive) was caused byMosaicism

shock crushing(passive) caused bymosaicism

Ring chromosomes are often unstable during mitosis ; as a result , it is common to find a ring chromosome in very minimal portion of cellsresultingmosaicism

LOH of variable chromosome(passive) caused bymosaicism

Mutational events occurring during embryonic developmentcan causemosaicism

a somatic recombination event in a monozygotic twin(passive) caused bymosaicism

subgenic lateral transfer(passive) caused bymosaicism

Additionally , editing may happen after first embryonic division , due to persistence of Cas9 : gRNA complexesalso causingmosaicism

Mutations occurring early in developmentcan causemosaicism

OHSU scientistspreventedmosaicism

any one of numerous factors from paternal , maternal , or exogenous factors such as culture media or ovarian hyperstimulation(passive) can be caused byMosaicism

when cells with the normal amount of chromosomes and cells with an added chromosome mix and replicate a chromosome 21 in the latter.[3 ] Women who give birth to a child with Down syndrome have a higher chance of having another Down syndrome child(passive) is causedMosaicism

shownto consistently preventmosaicism

that only some copies of targeted genes are modifiedcausingmosaicism

that the second hit occurred early in embryogenesiscausingmosaicism

doi:10.1371 / journal.pgen.1003467.g005causesmosaicism

DNA mutations , epigenetic alterations of DNA , chromosomal abnormalities and the spontaneous reversion of inherited mutations(passive) can be caused byMosaicism

this change in tactic actually workedto preventmosaicism

X - chromosome inactivation in femalescausesmosaicism

no more than 1 h ... the first DNA replicationto preventmosaicism

from a mutation during development which is propagated to only a subset of the adult cellsmay resultfrom a mutation during development which is propagated to only a subset of the adult cells

from a mutation during development which is propagated to only a subset of the adult cellmay resultfrom a mutation during development which is propagated to only a subset of the adult cell

from random X inactivation ( MGI Ref ID J:41605)cellular phenotypeabnormal megakaryocyteresultingfrom random X inactivation ( MGI Ref ID J:41605)cellular phenotypeabnormal megakaryocyte

from random X inactivation ( MGI Ref ID J:41605 ) excess of abnormal megakaryocytes in the yolk sac and early fetal liver ( MGI Ref ID J:41605resultingfrom random X inactivation ( MGI Ref ID J:41605 ) excess of abnormal megakaryocytes in the yolk sac and early fetal liver ( MGI Ref ID J:41605

from a phenomenon known as X - inactivationalso resultsfrom a phenomenon known as X - inactivation

to just a segment of the coat being that patchy merle patternleadingto just a segment of the coat being that patchy merle pattern

in some cases in absence of transmission of the mutation to the offspringresultedin some cases in absence of transmission of the mutation to the offspring

major phenotypic changes and reveal the expression of lethal genetic mutations [ 15can causemajor phenotypic changes and reveal the expression of lethal genetic mutations [ 15

from a postzygotic mutation of FGFR3resultingfrom a postzygotic mutation of FGFR3

from postzygotic somatic cell mutationresultingfrom postzygotic somatic cell mutation

from multiple phage recombination eventsresultingfrom multiple phage recombination events

Around 1 percent of all Down syndrome cases(passive) are caused byAround 1 percent of all Down syndrome cases

less than 2.7 % of Down syndrome casescausesless than 2.7 % of Down syndrome cases

Almost all cases of Pallister - Killian mosaic syndrome(passive) are caused byAlmost all cases of Pallister - Killian mosaic syndrome

to organisms with some tissues or organs that bear the targeted mutation and some that do notwould leadto organisms with some tissues or organs that bear the targeted mutation and some that do not

when a de novo mutation arises after an embryo is formedcan resultwhen a de novo mutation arises after an embryo is formed

from somatic mutation in early embryonic cells.43,44resultingfrom somatic mutation in early embryonic cells.43,44

genetic mutation for Progeria in a small percentage of mother ’s cellscausinggenetic mutation for Progeria in a small percentage of mother ’s cells

from a mutation that occurs during postzygotic development and is propagated to only a subset of the adult cellsmay resultfrom a mutation that occurs during postzygotic development and is propagated to only a subset of the adult cells

from a mutation in one cell during development in which the mutation is passed on to only its daughter cellscan also resultfrom a mutation in one cell during development in which the mutation is passed on to only its daughter cells

from a mutation in one cell during development in which the mutation is passed on to only Mosaicism 's daughter cellscan also resultfrom a mutation in one cell during development in which the mutation is passed on to only Mosaicism 's daughter cells

skewed inactivation of mutated X chromosome ... protecting male child from deleterious effects of this mutationcausingskewed inactivation of mutated X chromosome ... protecting male child from deleterious effects of this mutation

from meiotic recombination of a paternal inversion followed by mitotic recombination during the first embryonic divisionsresultingfrom meiotic recombination of a paternal inversion followed by mitotic recombination during the first embryonic divisions

from a known mosaic embryo transferresultingfrom a known mosaic embryo transfer

oftenresultsoften

Differing eye color in a person(passive) is caused byDiffering eye color in a person

a person to have two different colored eyescan causea person to have two different colored eyes

in traits expressed in seemingly random patterns ( e.g. , skin mosaicismoften resultsin traits expressed in seemingly random patterns ( e.g. , skin mosaicism

from de novo somatic eventsresultingfrom de novo somatic events

differences among a person 's cellscan createdifferences among a person 's cells

from mutations occurring at different times and sites in developmentresultingfrom mutations occurring at different times and sites in development

varying expressivity of inherited diseases , aggregation of disorders regarded as " new mutations " in ostensibly healthy families , and neoplasiamay causevarying expressivity of inherited diseases , aggregation of disorders regarded as " new mutations " in ostensibly healthy families , and neoplasia

to 2 cell lineages , which results in areas of hypopigmented ( light areas of skint ) and hyperpigmented skin ( darker areas of skinoften leadsto 2 cell lineages , which results in areas of hypopigmented ( light areas of skint ) and hyperpigmented skin ( darker areas of skin

The development of the segmental component in a generalized disease(passive) is caused byThe development of the segmental component in a generalized disease

Muckle - Wells syndrome in a collaborative study with the Spanish groupcausesMuckle - Wells syndrome in a collaborative study with the Spanish group

in tetraploidizationoriginatingin tetraploidization

from inactivation of an X - chromosome in femalesresultingfrom inactivation of an X - chromosome in females

Four clinical patterns ,(passive) caused byFour clinical patterns ,

from the use of this technologyresultingfrom the use of this technology

underscoring(passive) caused byunderscoring

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