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Qaagi - Book of Why

Causes

Effects

lifestyle and diet(passive) can be influenced by-Methylation

by the RdDM pathway(passive) caused byCHH methylation

by alteration in chromatin - modifying enzymes(passive) caused byhistone methylation

by Sam - S knockdown(passive) caused byhistone methylation

EZH2causeshistone methylation

a geneinfluencingcytosine methylation

de)acetylation , enzymes ... co - substrates or co - factorsinfluencehistone methylation

CARM1(passive) caused bySox9 methylation

Trialresultsmethylation chlorambucil

High maternal protein intakecausesRXRA methylation

Dna methylation and histone modifications influence transcription initiation the promoter transcriptioncan influencedmethylation

High maternal omega-6 intakecausesRXRA methylation

transcription(passive) is ... influenced byGenic methylation

induced by treatment of bacterial cells with alkylating agentscausemethylation Methylation

the geneinfluencesmethylation

treatment of bacterial cells with alkylating agentscausemethylation Methylation

by a class of proteins called DNA methyltransferases(passive) is causedmethylation

Folic acid ( folatemight influencemethylation

Folic acid ( folatemight influencemethylation

these key genescan influencemethylation

by these mutations(passive) caused bymethylation

by those factors(passive) caused bymethylation

factorsinfluencingmethylation

genetic effectsinfluencingmethylation

environmental factors , such as diet , illness , and stress(passive) can be influenced byMethylation

nutrientsinfluencemethylation

Smokingcausesmethylation

by this toxic process(passive) caused bymethylation

by elevated homocysteine(passive) caused bymethylation

by AdOx treatment(passive) caused bymethylation

environmental factors(passive) can be caused byMethylation

also(passive) is ... influencedMethylation

by epigenetic events(passive) influenced bymethylation

Knockdown of sams genes encoding s - adenosyl - l - methionine synthetasescausesmethylation

environmental factors and aging(passive) is influenced byMethylation

Knownhow ... is originatedmethylation

by environmental influences ( e.g. smoking , stress(passive) can be caused byMethylation

by elevated SAH(passive) caused bymethylation

by NESP55 deletion(passive) caused bymethylation

Other things that have been shownto causemethylation

cumulative damage to our cells and our systemcausecumulative damage to our cells and our system

the development and clinical course of MDDinfluencesthe development and clinical course of MDD

the genomic profiles of tumorscan influencethe genomic profiles of tumors

DNA silencing through inhibiting the transcriptional compound binds to DNA , interfering by transcriptional corepressor complex , or chromatin remodelingcan causeDNA silencing through inhibiting the transcriptional compound binds to DNA , interfering by transcriptional corepressor complex , or chromatin remodeling

the downregulation of CXCL14 , a modulator of immunity and inflammationcausesthe downregulation of CXCL14 , a modulator of immunity and inflammation

to gene silencingcontributesto gene silencing

to transcriptional repression and gene silencing at the NRF2 promoterleadingto transcriptional repression and gene silencing at the NRF2 promoter

to activation or repression of gene transcriptioncan leadto activation or repression of gene transcription

to the accumulation of mutations throughout the genome targeting important genesleadingto the accumulation of mutations throughout the genome targeting important genes

to the silencing of genes critical to cellular control ( i.e. , epigenetic gene silencingcan leadto the silencing of genes critical to cellular control ( i.e. , epigenetic gene silencing

to the altered expression of related genescontributesto the altered expression of related genes

in the repression of numerous tumor suppressor or promoter genesresultingin the repression of numerous tumor suppressor or promoter genes

in either transcriptional activation or repressioncan resultin either transcriptional activation or repression

a permanent change in gene activity during developmentcausesa permanent change in gene activity during development

to the loss of expression of neighboring genes without DNA methylationleadingto the loss of expression of neighboring genes without DNA methylation

gene silencingcausesgene silencing

to gene silencingleadsto gene silencing

in tumor suppressor gene inactivationresultingin tumor suppressor gene inactivation

to the silencing of gene expressionleadingto the silencing of gene expression

transcriptional silencingcausestranscriptional silencing

in good response for the refractory AMLresultingin good response for the refractory AML

epigenetic silencing(passive) caused byepigenetic silencing

in more or less gene transcriptionDoes ... resultin more or less gene transcription

gene inactivationcausesgene inactivation

gene suppressioncausesgene suppression

to DE transcriptional silencingleadto DE transcriptional silencing

to decreased transcriptionleadingto decreased transcription

in decreased transcriptionresultingin decreased transcription

to activation or repression of <can leadto activation or repression of <

a change in the DNA structure of particular genes and resultscausesa change in the DNA structure of particular genes and results

in growth suppressor gene inactivationresultingin growth suppressor gene inactivation

in low homocysteine levelswill resultin low homocysteine levels

to the inactivation of a given genecan leadto the inactivation of a given gene

whether genes are active or inactiveinfluencewhether genes are active or inactive

to gene reactivationleadsto gene reactivation

a change in the DNA structure of particular genes and results in altering its controlcausesa change in the DNA structure of particular genes and results in altering its control

its expression and BRCA1 expressionmight ... influenceits expression and BRCA1 expression

a gene to be turned off , or silencedcausesa gene to be turned off , or silenced

to silencingresultsto silencing

to gene silencing in a proportion of BRAF mutant cancersmay be contributingto gene silencing in a proportion of BRAF mutant cancers

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