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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

This depth of peptide insertionwould leadto negative membrane curvature strain

Monomeric forms of alpha - synucleinmay contributeto endophilin - A1-related membrane curvature

the asymmetry(passive) can be caused byLocal curvature of the membrane

the asymmetry and non - bilayer organization of lipids(passive) can be caused byLocal curvature of the membrane

the lipid phase boundarycausesnegative membrane curvature

Formation of dimers or oligomers of the F1Fo ATP synthase complexcausesextreme curvature of the inner membrane

M2 ... the lipid phase boundarycausesnegative membrane curvature

tighter head group packing in the outer membrane leafletleadingto positive membrane curvature

This membrane motioncausesmembrane deformation

by acoustic waves(passive) caused byMembrane deformation

the cytoskeletoninfluencesmembrane shape

proteinsinfluencemembrane curvature during vesicle budding

parametersdesignedto mimic membrane curvature

This results in the local accumulation of the cone - shaped diacylglycerol in the outer leaet of the lipid bilayercausingmembrane curvature and constriction

by pressure(passive) caused bymembrane deformations

by heat(passive) caused bymembrane deformations

The unique structure and interaction between the two layersresultin membrane curvature and scission

An asymmetric distribution of membrane lipidscausesmembrane bending

small channels ( porescausesmembrane destabilization

also(passive) can ... be influencedMembrane curvature

proteinscausemembrane curvature

Proteinsalso contributeto the membrane curvature

by protein crowding(passive) caused bymembrane bending

by the cellular attachment(passive) caused bymembrane permeability

ergosterol depletion(passive) caused bymembrane permeability

by LPS(passive) caused bymembrane permeability

the tubulin homologue(passive) leaded bymembrane constriction

These results provide atomic - level evidence of M2-cholesterol interactionto causemembrane curvature and scission

by the alteration in sterol(passive) caused bymembrane permeability

orderto resultin curvature of the membrane

On the other handdid ... causemembrane permeability

necrosis(passive) caused bymembrane permeability

magnetic fieldsmight influencemembrane permeability

Fluorine / hydrogen exchangeto influencemembrane permeability

This translationleadsto a curvature in the membrane

by static disorder(passive) caused bymembrane curvature

this complexcausesmembrane protrusion

Elastic , electrostatic and electrokinetic forcesinfluencingmembrane curvature

exposure to excitatory amino acids such as glutamate(passive) caused bymembrane excitability

Therefore the size of polar head groups compared to the acyl chain determines the intrinsic shape of the lipid andcan ... influencemembrane curvature

in cell leakage ( 28would ... resultin cell leakage ( 28

to virusleadingto virus

to virus budding into the Golgi lumenleadingto virus budding into the Golgi lumen

substantially to intracellular membrane sorting and traffickingcontributessubstantially to intracellular membrane sorting and trafficking

defectscausesdefects

to invaginationleadingto invagination

in the formation of tubules / vesicles which transports cargo molecules to the trans - golgi network ( TGNresultingin the formation of tubules / vesicles which transports cargo molecules to the trans - golgi network ( TGN

from formation ( Li et alresultsfrom formation ( Li et al

from accumulationresultsfrom accumulation

of a lipid bilayer of phospholipids with the hydrophobic edge screened by two amphipathic proteinscomposedof a lipid bilayer of phospholipids with the hydrophobic edge screened by two amphipathic proteins

from appearance ( Li et alresultsfrom appearance ( Li et al

from creation ( Li et alresultsfrom creation ( Li et al

from formationresultsfrom formation

from accumulationresultsfrom accumulation

to cell lysis and/or changes in membrane barrier functionleadingto cell lysis and/or changes in membrane barrier function

to membrane curvaturesleadsto membrane curvatures

from asymmetric insertion of amphipathic compounds into the lipid membraneresultsfrom asymmetric insertion of amphipathic compounds into the lipid membrane

damage and membrane disruption as well as reduction in photosynthesiscausesdamage and membrane disruption as well as reduction in photosynthesis

to the leakage of liver enzymes into extracellular spaceleadsto the leakage of liver enzymes into extracellular space

to leakage of cellular componentsleadingto leakage of cellular components

leakage of the cytoplasm and deathcausingleakage of the cytoplasm and death

the cellcausingthe cell

to cellleadsto cell

movement of ionscausingmovement of ions

to cell deathleadsto cell death

in rapid cell death ... 28resultsin rapid cell death ... 28

from interactions with proteinsresultfrom interactions with proteins

of actin - rich structurescomposedof actin - rich structures

to fusionleadingto fusion

to rapidwill leadto rapid

to ionleadsto ion

alsocan ... causealso

receptor potentials 3causingreceptor potentials 3

to the inactivation of bacterialeadsto the inactivation of bacteria

in resistance to host antimicrobial peptidesresultsin resistance to host antimicrobial peptides

to the uptake of the dyeledto the uptake of the dye

from formation ( Li et alresultsfrom formation ( Li et al

organelle swellingcausingorganelle swelling

in a change of focal length at different place of the lensresultsin a change of focal length at different place of the lens

in intracellular metabolite leakingmight resultin intracellular metabolite leaking

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Smart Reasoning:

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