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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

the CURT1 proteinscould causecurvature in a membrane

Interactions between viral proteinsleadto membrane curvature

small molecules to be stable and observed in real - time ( 39(passive) caused bymembrane curvature

which interact with cavin coat proteinsto createmembrane curvature for invagination

Sar1-GTP on the membrane recruits COPII proteinsresultingin membrane curvature

Clathrin and associated coat proteins and the BAR domain of PICK1may contributeto membrane curvature

Electrostatic interactions between the positively charged ends of the I - BAR domains and negatively charged hydrophobic phosphatidyl - ionositol-4-biphosphate [ PI ( 4,5 ) P2 ] groupscausecurvature of the membrane

Figure 1a).Cellular membranes ... both of whichcan contributeto membrane curvature

that flippases might affect vesicle formation as a consequence of enrichment of specific phospholipids in one side of bilayered membranes [ 112leadingto membrane curvature

Finally , the plasma membrane at the assembly site bends ,causingan outward membrane curvature

The drastic change in lipid geometry on the inner leaflet in the vicinity of the channelcreatesmembrane curvature

the differential lipid composition of the two membrane monolayers(passive) is influenced byMembrane curvature

bilayer surface discrepancycausesmembrane curvature

The transmembrane densitiescreatea high membrane curvature

its lipid displacement arealeadingto membrane curvature

lateral heterogeneities as well as a means to induce lateral heterogeneity(passive) can be influenced byCurvature of the membrane

Eps15(passive) created bycurved membrane

the cargo protein and the second layer of coating , consisting of Sec13 , forms around the Sec23–Sec24causingmembrane curvature

e ) Charge imbalanceresultingin membrane curvature

In particular , in these explicit membrane simulations , Lys40 , residing at the C - terminal side of the*transmembrane helix , is observedto causelocal membrane curvature

newly foundcontributesto the membrane curvature

Mechanismscausingmembrane curvature

that this disturbs the bilayer 's stabilitycontributingto membrane curvature

that presumably presses the membrane against its underbellyto createmembrane curvature

A tethered amphipathic helix in P / rds ... well positionedto createmembrane curvature

that the M201‐K213 sequence exerts its function through some alternative conformational structureto createmembrane curvature

localized ER membrane tensionsresultin membrane curvature

In particular , in these explicit membrane simulations , Lys(40 ) , residing at the C - terminal side of the*transmembrane helix , is observedto causelocal membrane curvature

localised ER membrane tensionsresultin membrane curvature

lipid membrane interactionsinfluencedmembrane curvature

hence introduces a different type or extent of interface stressesthus contributingto membrane curvature

an N - terminal amphipathic helix cooperates with a dimeric or oligomeric curved BAR - domain scaffoldto createmembrane curvature

any protein binding asymmetrically on a membrane(passive) should ... be influenced bymembrane curvature

B ) Acidificationleadsto membrane curvature

Individual dimers , partially arranged in tip - to - tip arrayscauselocal membrane curvature

The packing and distribution of membrane constituentscreateslocal membrane curvature

CPPs use less hydrophobic amino acidsto createcurvature in the membrane

the oligomerization of hexagonal blocks of NECs1,32(passive) can be caused bymembrane curvature

mechanical force(passive) created bymembrane curvature

When contacting the membrane , helix 0 forms and inserts partially into the membranecreatingmembrane curvature

in ER tubule formationresultingin ER tubule formation

to budding , invagination and fusionleadsto budding , invagination and fusion

to liposome budding , fusion , and invaginationleadingto liposome budding , fusion , and invagination

to budding of the virionleadsto budding of the virion

to the budding of the granulesleadsto the budding of the granules

in invagination ( Huttner and Schmidt , 2000resultingin invagination ( Huttner and Schmidt , 2000

to the formation of deep invaginations and tubules not only in the plasma membrane of cells , but also in giant unilamellar vesicles ( GUVsleadsto the formation of deep invaginations and tubules not only in the plasma membrane of cells , but also in giant unilamellar vesicles ( GUVs

organelle tubulation , which is followed by recruitment of a large GTPase of the DRP superfamily that performs scission [ 13 ] , [ 16 ] , [ 17causesorganelle tubulation , which is followed by recruitment of a large GTPase of the DRP superfamily that performs scission [ 13 ] , [ 16 ] , [ 17

the structure(passive) created bythe structure

accumulation of Bif-1 on target sites that would further enhance the curvature of these membranesmay causeaccumulation of Bif-1 on target sites that would further enhance the curvature of these membranes

in both the constriction and scission of membranes ( Praefcke & McMahon 2004 , McMahon & Gallop 2005resultsin both the constriction and scission of membranes ( Praefcke & McMahon 2004 , McMahon & Gallop 2005

to the productive formation of a clathrin - coated vesicleleadingto the productive formation of a clathrin - coated vesicle

an asymmetry in the flow field in front of the microbubblecausedan asymmetry in the flow field in front of the microbubble

to a reduction in sterol - phospholipid association in cholesterol - rich membranescan leadto a reduction in sterol - phospholipid association in cholesterol - rich membranes

to aberrant recruitment of proteinsleadingto aberrant recruitment of proteins

in the growth of highly curved tubular structuresresultingin the growth of highly curved tubular structures

possiblycould ... originatepossibly

to the formation of tight - fitting , virus - filled invaginations and tubules of the plasma membrane of monkeyledto the formation of tight - fitting , virus - filled invaginations and tubules of the plasma membrane of monkey

in compressive forces within the vesicleresultingin compressive forces within the vesicle

lipid sorting in pure lipid mixtures as well as in biological membranesto causelipid sorting in pure lipid mixtures as well as in biological membranes

the concentration of components(passive) may be influenced bythe concentration of components

Deformation energy(passive) created byDeformation energy

in the formation of invaginations and ... subsequently ... of vesicular - tubular structures which depend on the self - assembly of F - BAR modules into a helical coatresultsin the formation of invaginations and ... subsequently ... of vesicular - tubular structures which depend on the self - assembly of F - BAR modules into a helical coat

from electromotile length changesresultingfrom electromotile length changes

biomacromolecular interaction processes(passive) are influenced bybiomacromolecular interaction processes

from this facilitates CCV formation and provides several opportunities for cellular regulationresultsfrom this facilitates CCV formation and provides several opportunities for cellular regulation

this fusion process(passive) is triggered bythis fusion process

from circumferential fusion of NE membrane leaflets to form the pore in which the NPC residesresultingfrom circumferential fusion of NE membrane leaflets to form the pore in which the NPC resides

to the formation of deep invaginations and tubules , important for successful infection [ 8leadsto the formation of deep invaginations and tubules , important for successful infection [ 8

an autophagy - dependent membrane quality control response that appears to be enhanced in mutants with altered clathrin functiontriggersan autophagy - dependent membrane quality control response that appears to be enhanced in mutants with altered clathrin function

to its disruptionleadsto its disruption

to dimple formation and merger of outer bilayer leaflets creating a presumed hemifusion intermediate ( leftleadingto dimple formation and merger of outer bilayer leaflets creating a presumed hemifusion intermediate ( left

to vesicle initiation ( Szule et al . , 2002 ; Fig . 2contributingto vesicle initiation ( Szule et al . , 2002 ; Fig . 2

to endocytosis or vesicle secretionleadingto endocytosis or vesicle secretion

to the generation of a procoagulant activityleadingto the generation of a procoagulant activity

the channel molecule(passive) caused bythe channel molecule

in this region of the moleculewas discoveredin this region of the molecule

in general changes in the ER morphologywould resultin general changes in the ER morphology

to long - range repulsion ( 14 , 49pos - sibly leadingto long - range repulsion ( 14 , 49

to the observed invaginations and the counterpart to these morphological alterationscontributesto the observed invaginations and the counterpart to these morphological alterations

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Smart Reasoning:

C&E

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