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Qaagi - Book of Why

Causes

Effects

AB - The structural modifications on the B - region of the potent and high affinity vanilloid receptor ( VR1leadligand N-(3-acyloxy-2-benzylpropyl)-

to provide the linkage between chemical & biological aspects of life in light of enzymatic reactions(passive) is designedLIGAND

6 ) TABLE 5 FKBP-12 in vitro binding assayresultsLigand

pharmacological or genetic inhibition of ATR , ATM or Chk1 ( a downstream transducer kinase in the pathway(passive) was prevented byLigand upregulation

The absence of one SpreventsCys ligand

Monoclonal antibodies and anti - TGF - β drugscan preventligand

rat bone marrow - derived cellscan contributeto the ligand

Mutations in both genesleadto ligand

This antibody makesto preventligand

DOI : 10.1002 / anie.201205840 Using Ligand - Mapping Simulationsto Designa Ligand

In these cases , the differences between the test compound concentration and the rapamycin control concentration were taken into account using equation 6 below : [ 0000 ] TABLE 5 FKBP-12 in vitro binding assayresultsLigand

control of all of the conformational statescontributeto ligand

e.g. , � C6H5resultingligand : H2(ppb

how one specific multi - targetdesignedligand ( MTDL

For example , bevacizumab targets VEGF - Ato causeligand sequestering

Onartuzumab ... a single - arm antibodypreventsligand

growth necrosis factor - related apoptosiscausingligand ( TRAL

the GUM scope , the largest way use in the cybersecurity(passive) is painted bythe ligand-

An important pH in Pre - NOTCH horizon in the Golgileadsligand

one cell ties to a receptor in the extracellular area of another cell(passive) created byA ligand

of one pyridine unit and two n - butyl - substituted pyrazoles ( pyrz(passive) is composedThe ligand

Binding ability of the adsorbed ligate ( Monoclonal antibody ) to the radiolabelledligand ( chg

intermolecular H - bonding effects as well as steric and electronic factorsinfluencethe ligand

Ramucirumab , a human IgG1 monoclonal antibody directed to the ectodomain of VEGFR-2preventsligand

one - bead - one - compound combinatorial technology as a potent and specific EPC / EC targeting ligand(passive) discovered byligand LXW7

to target many different tumor proteins , such as the folate receptor , which is present on about one - third of human cancers , and prostate - specific membrane antigen , which is present in prostate cancer tumors(passive) can be designedThe ligand

of two parts , one carrying the activity ( agonist or antagonist ) at the different subtypes of OR , the “ message ” and one part , the “ address , ” conveying selectivity toward a given OR ( Portoghese et al . , 1990(passive) is composedthe ligand

Cells were first incubated with a mixture of metabolic inhibitors ( 50 mmol / L 2-deoxy - D - glucose , 15 mmol / L NaN3 , and 1 mg / mL BSA in PBSto preventligand internalization

to bind Ln(III(passive) has been designedThe ligand

EH&Swill leadLigand

Aglaia Oncology Fundcancercervical cancerclinical - stage biopharmaceutical companyfundingGerard PlatenburgISA Pharmaceuticals B.V.persistent viral infectionsproprietary toll - like receptor ( TLRdesignedligand adjuvant

the potential redox noninnocence of hydrazido ligandscould leadto ligand-

on HLA - E(passive) is composedThe ligand

from attaching to the surface via sites important to the interaction under study by having analyte present during immobilization(passive) may be preventedThe ligand

considerable effortdesigningthe ligand

the metal complex(passive) contributed bya ligand

The complex between the ligand and the soluble receptorpreventsthe ligand

the agent being tested(passive) caused bya ligand

The Sixth Editioncausesthe ligand

to fullfill the requirement(passive) was designedOne ligand

to Isolation of Low - Coordinate Transition Metal Complexes , AngewLeadsto Isolation of Low - Coordinate Transition Metal Complexes , Angew

allergen - induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathwayAbstractFulltextPDFWeb of Science ... 39)Scopuspreventsallergen - induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathwayAbstractFulltextPDFWeb of Science ... 39)Scopus

dimerization of receptorcausesdimerization of receptor

allergen - induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathwayAbstractFulltextPDFRole of Breast Milk in a Mouse Model of Maternal Transmission of Asthmapreventsallergen - induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathwayAbstractFulltextPDFRole of Breast Milk in a Mouse Model of Maternal Transmission of Asthma

activation of the kinase VEGFRpreventsactivation of the kinase VEGFR

allergen - induced air Structural equation modeling of gene - environment interactions in coronary heart diseasepreventsallergen - induced air Structural equation modeling of gene - environment interactions in coronary heart disease

on the structures of copper molybdate chainsinfluenceson the structures of copper molybdate chains

frequentlycausedfrequently

several orally active , non - steroidal SARM compounds based on tissue - specific gene expression and other functional , cell - based technologieshas discoveredseveral orally active , non - steroidal SARM compounds based on tissue - specific gene expression and other functional , cell - based technologies

receptor activation(passive) caused byreceptor activation

to receptor mediated internalization of NPs into the cells [ 14leadsto receptor mediated internalization of NPs into the cells [ 14

novel research and technologies for approved medicines that treat cancer , osteoporosis , fungal infections , low blood platelets , among othershas contributednovel research and technologies for approved medicines that treat cancer , osteoporosis , fungal infections , low blood platelets , among others

interleukin-6 secretion in multiple myeloma M Urashima , D Chauhan , H Uchiyama , GJ Freeman and KC Anderson Blood 1995triggeredinterleukin-6 secretion in multiple myeloma M Urashima , D Chauhan , H Uchiyama , GJ Freeman and KC Anderson Blood 1995

the SARM LGD-2941 , which TAP is developing in a Phase I clinical trialdiscoveredthe SARM LGD-2941 , which TAP is developing in a Phase I clinical trial

platelet release of reactive oxygen intermediates Textinfluencesplatelet release of reactive oxygen intermediates Text

in resolution of PCOS - associated endocrine and metabolic disturbances and restored reproductive functionresultedin resolution of PCOS - associated endocrine and metabolic disturbances and restored reproductive function

of unsubstituted or substituted mono- , bi- or multicyclic ring systems selected from aromatic or non - aromatic or partially saturated ring systems and containing carbon ring atoms and optionally one or more heteroatoms selected from Groups 15 and 16 of the Periodic Tablecomposedof unsubstituted or substituted mono- , bi- or multicyclic ring systems selected from aromatic or non - aromatic or partially saturated ring systems and containing carbon ring atoms and optionally one or more heteroatoms selected from Groups 15 and 16 of the Periodic Table

conformational change of VDR - RXR heterodimerstriggeredconformational change of VDR - RXR heterodimers

in signal activation or inhibitionresultingin signal activation or inhibition

the phosphorylation of c - Fos(passive) triggered bythe phosphorylation of c - Fos

the strength of bindingstrongly influencesthe strength of binding

binding and dimerizationcausesbinding and dimerization

novel , selective , small moleculehas discoverednovel , selective , small molecule

transcription elements and constituent transcriptional repressors20 encoded from the genes and respectivelytriggeredtranscription elements and constituent transcriptional repressors20 encoded from the genes and respectively

autocrine signaling in acute myeloid leukemia cells — Johns Hopkins Universitycausesautocrine signaling in acute myeloid leukemia cells — Johns Hopkins University

binding of TK receptor subunitscausesbinding of TK receptor subunits

conformational changes(passive) caused byconformational changes

the first switches(passive) triggered bythe first switches

that lectin complement pathway activation(passive) triggered bythat lectin complement pathway activation

activation energy(passive) caused byactivation energy

to receptor clusteringleadingto receptor clustering

receptor interactionsleadreceptor interactions

trimerization of their receptorwould causetrimerization of their receptor

strong TCR /causesstrong TCR /

binding of the agonist ... either directly ( competitive binding ) or indirectly ( allostericpreventsbinding of the agonist ... either directly ( competitive binding ) or indirectly ( allosteric

of CD40 on DC 10 , 11triggeringof CD40 on DC 10 , 11

zantac usa bindingcauseszantac usa binding

to a distortion of the binding parametercould ... leadto a distortion of the binding parameter

Changes in protein conformation(passive) triggered byChanges in protein conformation

the Drosophila JNK pathwaytriggersthe Drosophila JNK pathway

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