to target many different tumor proteins , such as the folate receptor , which is present on about a third of human cancers ; and prostate - specific membrane antigen , which is present in prostate cancer tumors(passive) can be designedThe ligand
The formation of hydrogen bonds with the atoms of these two residues by an appropriately placed ligandcould leadto ligand
to target many different tumor proteins , such as the folate receptor , which is present on about a third of human cancers ; and prostate - specific membrane antigen , which is present in prostate cancer t(passive) can be designedThe ligand
to target many different tumor proteins , such as the folate receptor , which is present on about one - third of human cancers , and prostate - specific membrane antigen , which is present in prostate cancer tumors(passive) can be designedThe ligand
to target many different tumor proteins , such as the folate receptor , which is present on about one - third of human cancers , and prostate - specific membrane antigen , which is present in prostate cancer(passive) can be designedThe ligand
the change in the conformation of the receptorleadsto ' ligand
the particular amino acid residuescontributeto ligand
even when ... , there appear to be feedback mechanisms that affect receptor expression or activityoriginatesligand
the binding pocketledto the ligand
Mutations in EGFRleadto ligand
by the metal complex(passive) contributed bya ligand
The antibodies ... that domain or domainscontributesto ligand
the extracellular regiondoes ... contributeto ligand
residuescontributingto ligand
a domaininfluencingligand
interactionscontributingto ligand
The active interaction between M ' andleadsthe ligand
All four transmembrane helicescontributeto ligand
All of these factorsmay influenceligand
factorscontributingto ligand
which has been shownto contributeto ligand
all amino acids in a regionto contributeto ligand
of a group of atoms(passive) is composedA ligand
factor - related apoptosiscausingligand
The RES binding site ... this is thought ... affinity.[4to contributeto ligand
three subunitscontributeto ligand
This processcan causeligand
The cytoplasmic domain of CD44contributesto ligand
subunits was proposedto ... contributeto ligand
NKG2Dcontributesligand
both subunitscontributingto ligand
trimerization of their receptor ... but recent studies ( 19 ) point to the existence of preassembled receptorswould causetrimerization of their receptor ... but recent studies ( 19 ) point to the existence of preassembled receptors
from AIE active building block tetraphenylamine ( TPEis designedfrom AIE active building block tetraphenylamine ( TPE
signaling in acute myeloid leukemia cellscauses autocrinesignaling in acute myeloid leukemia cells
bindingprovokesbinding
autocrine signaling in acute myeloid leukemia cellscausesautocrine signaling in acute myeloid leukemia cells
to the initiation and progression of atherosclerosismight contributeto the initiation and progression of atherosclerosis
T - cell stimulation , proliferation , activation , and apoptosis ( 3causingT - cell stimulation , proliferation , activation , and apoptosis ( 3
reversible S - nitrosylationcausingreversible S - nitrosylation
in an entropic advantageshould resultin an entropic advantage
autocrine signaling incausesautocrine signaling in
in constitutive activity of an ErbB receptorpossibly resultingin constitutive activity of an ErbB receptor
autocrinecausesautocrine
to strong synergistic effectsleadsto strong synergistic effects
T - cell anergy / exhaustion of tumor infiltrating lymphocytescausingT - cell anergy / exhaustion of tumor infiltrating lymphocytes
to photoreceptor cell deathmay leadto photoreceptor cell death
to a lowering energy gap of HOMO - LUMOleadsto a lowering energy gap of HOMO - LUMO
receptor responseinfluencesreceptor response
to an appropriate localised activation of BMP signalling at either pole of the DV axisleadsto an appropriate localised activation of BMP signalling at either pole of the DV axis
a conformational change at a site remote from ligand bindingcausesa conformational change at a site remote from ligand binding
in activation of downstream kinases that inhibit apoptotic responseresultsin activation of downstream kinases that inhibit apoptotic response
to receptor mediated internalization of NPs into the cellsleadsto receptor mediated internalization of NPs into the cells
the activity of effector cellsinfluencesthe activity of effector cells
The overall receptor conformation(passive) influenced byThe overall receptor conformation
in intracellular signalingresultingin intracellular signaling
in the recruitment of a functionally limiting set of coactivator proteins that are used in common by several nuclear receptorsresultsin the recruitment of a functionally limiting set of coactivator proteins that are used in common by several nuclear receptors
to changes in receptor shapeleadsto changes in receptor shape
the receptor to change its behavior toward the cellcausesthe receptor to change its behavior toward the cell
bindingleadsbinding
bindingprovokesbinding
bindingcausesbinding
bindingleadsbinding
to a chemical signal being transmitted into the cellleadingto a chemical signal being transmitted into the cell
to the enhanced chemotaxis of cells bearing these mutantscontributesto the enhanced chemotaxis of cells bearing these mutants
in compounds with improved selectivity for factorresultedin compounds with improved selectivity for factor
The recombinant protein(passive) is designedThe recombinant protein
in a more efficient induction of coupled reporter genesresultsin a more efficient induction of coupled reporter genes
in compounds withresultedin compounds with
a biological effectcausinga biological effect
there to be a large ligand field splitting parametercausesthere to be a large ligand field splitting parameter