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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

inside vitro(passive) was causedLigand upregulation

to mimic Asn35 and Trp43 of Protein G(passive) was designedLigand A2C11I1

A fusion proteincomposedof CD40 ligand

these ligandswere designedas a tridentate ligand

The reaction of the enantiopureleadsimine ligand

PROTACcomposedof the TRIM24 ligand

These differencesinfluenceligand specificities

receptor clusteringmight influenceligand rebinding

systemscomposedof periplasmic ligand

to target many different tumor proteins , such as the folate receptor , which is present on about a third of human cancers ; and prostate - specific membrane antigen , which is present in prostate cancer tumors(passive) can be designedThe ligand

The formation of hydrogen bonds with the atoms of these two residues by an appropriately placed ligandcould leadto ligand

to target many different tumor proteins , such as the folate receptor , which is present on about a third of human cancers ; and prostate - specific membrane antigen , which is present in prostate cancer t(passive) can be designedThe ligand

to target many different tumor proteins , such as the folate receptor , which is present on about one - third of human cancers , and prostate - specific membrane antigen , which is present in prostate cancer tumors(passive) can be designedThe ligand

to target many different tumor proteins , such as the folate receptor , which is present on about one - third of human cancers , and prostate - specific membrane antigen , which is present in prostate cancer(passive) can be designedThe ligand

the change in the conformation of the receptorleadsto ' ligand

the particular amino acid residuescontributeto ligand

even when ... , there appear to be feedback mechanisms that affect receptor expression or activityoriginatesligand

the binding pocketledto the ligand

Mutations in EGFRleadto ligand

by the metal complex(passive) contributed bya ligand

The antibodies ... that domain or domainscontributesto ligand

the extracellular regiondoes ... contributeto ligand

residuescontributingto ligand

a domaininfluencingligand

interactionscontributingto ligand

The active interaction between M ' andleadsthe ligand

All four transmembrane helicescontributeto ligand

All of these factorsmay influenceligand

factorscontributingto ligand

which has been shownto contributeto ligand

all amino acids in a regionto contributeto ligand

of a group of atoms(passive) is composedA ligand

factor - related apoptosiscausingligand

The RES binding site ... this is thought ... affinity.[4to contributeto ligand

three subunitscontributeto ligand

This processcan causeligand

The cytoplasmic domain of CD44contributesto ligand

subunits was proposedto ... contributeto ligand

NKG2Dcontributesligand

both subunitscontributingto ligand

trimerization of their receptor ... but recent studies ( 19 ) point to the existence of preassembled receptorswould causetrimerization of their receptor ... but recent studies ( 19 ) point to the existence of preassembled receptors

from AIE active building block tetraphenylamine ( TPEis designedfrom AIE active building block tetraphenylamine ( TPE

signaling in acute myeloid leukemia cellscauses autocrinesignaling in acute myeloid leukemia cells

bindingprovokesbinding

autocrine signaling in acute myeloid leukemia cellscausesautocrine signaling in acute myeloid leukemia cells

to the initiation and progression of atherosclerosismight contributeto the initiation and progression of atherosclerosis

T - cell stimulation , proliferation , activation , and apoptosis ( 3causingT - cell stimulation , proliferation , activation , and apoptosis ( 3

reversible S - nitrosylationcausingreversible S - nitrosylation

in an entropic advantageshould resultin an entropic advantage

reduced microglia numberscausedreduced microglia numbers

autocrine signaling incausesautocrine signaling in

in constitutive activity of an ErbB receptorpossibly resultingin constitutive activity of an ErbB receptor

autocrinecausesautocrine

to strong synergistic effectsleadsto strong synergistic effects

T - cell anergy / exhaustion of tumor infiltrating lymphocytescausingT - cell anergy / exhaustion of tumor infiltrating lymphocytes

to photoreceptor cell deathmay leadto photoreceptor cell death

to a lowering energy gap of HOMO - LUMOleadsto a lowering energy gap of HOMO - LUMO

receptor responseinfluencesreceptor response

to an appropriate localised activation of BMP signalling at either pole of the DV axisleadsto an appropriate localised activation of BMP signalling at either pole of the DV axis

a conformational change at a site remote from ligand bindingcausesa conformational change at a site remote from ligand binding

in activation of downstream kinases that inhibit apoptotic responseresultsin activation of downstream kinases that inhibit apoptotic response

to receptor mediated internalization of NPs into the cellsleadsto receptor mediated internalization of NPs into the cells

the activity of effector cellsinfluencesthe activity of effector cells

The overall receptor conformation(passive) influenced byThe overall receptor conformation

in intracellular signalingresultingin intracellular signaling

in the recruitment of a functionally limiting set of coactivator proteins that are used in common by several nuclear receptorsresultsin the recruitment of a functionally limiting set of coactivator proteins that are used in common by several nuclear receptors

to changes in receptor shapeleadsto changes in receptor shape

the receptor to change its behavior toward the cellcausesthe receptor to change its behavior toward the cell

bindingleadsbinding

bindingprovokesbinding

bindingcausesbinding

bindingleadsbinding

to a chemical signal being transmitted into the cellleadingto a chemical signal being transmitted into the cell

to the enhanced chemotaxis of cells bearing these mutantscontributesto the enhanced chemotaxis of cells bearing these mutants

in compounds with improved selectivity for factorresultedin compounds with improved selectivity for factor

The recombinant protein(passive) is designedThe recombinant protein

in a more efficient induction of coupled reporter genesresultsin a more efficient induction of coupled reporter genes

in compounds withresultedin compounds with

a biological effectcausinga biological effect

there to be a large ligand field splitting parametercausesthere to be a large ligand field splitting parameter

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