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Qaagi - Book of Why

Causes

Effects

abnormalitiescausesresistance to insulin action[13

associatedcausesinsulin insulin resistance resistance

Tissue?specific overexpression of lipoprotein lipasecausestissue?specific insulin resistance

glucose production in the livercauseswidespread insulin resistance

the livercauseswidespread insulin resistance

Fat feedingcauseswidespread insulin resistance

Diabetes may also occur as a result of certain rare disorders associated with abnormalities of insulin or the insulin receptorcausingextreme insulin resistance

a situationcausingextreme insulin resistance

rare genetic changes(passive) caused byextreme insulin resistance

most commonly(passive) is ... causedExtreme insulin resistance

the potentialto causemaintain insulin resistance

cytokinescausemaintain insulin resistance

Two syndromes in children , leprechaunism and the Rabson - Mendenhall syndromecauseextreme insulin resistance

adipocytescausingadipocyte insulin resistance

glucose uptake and suppression of lipolysiscausingadipocyte insulin resistance

Inflammation , insulin resistance , obesity , and excessive insulincausesinsulin resistance

no evidencecausesworsens insulin resistance

by fat in the liver and pancreas ... and that fat in these organs is caused by insulin(passive) is ... caused byinsulin resistance

by excessive sugar and processed fructose consumption(passive) is ... caused byInsulin resistance

the fat tissues , liver , and skeletal muscles ... the insulincausesinsulin resistance

while fructose consumption will drive the accumulation of liver fatcausinginsulin resistance

by eating so that high levels of glucose are constantly in the blood , which causes high levels of insulin to be in the blood(passive) is caused byinsulin resistance

high levels of insulin ... fatcausesinsulin resistance

an excess of insulin in the bodycausesinsulin resistance

by insulin itself ... triggered by an excess consumption of dietary carbohydrate(passive) is caused byinsulin resistance

insulin itself ... triggered by an excess consumption of dietary carbohydrate(passive) is caused byinsulin resistance

too much sugar results in excess insulin ... the bloodcan causeinsulin resistance

In addition to these effects of lipid metabolites on insulin receptor signalling , oxidative stress and inflammationcan causeinsulin resistance

by a high - carbohydrate diet Causes of diabetes(passive) might be caused byinsulin resistance

eating too many sugars , [ processed ] grains and especially fructose(passive) caused byinsulin resistance

excessive fat in the liver that prevents the body from absorbing sugar(passive) is largely caused byInsulin resistance

a chronic elevated level of insulincausesinsulin resistance

why excess insulin causes type 2 diabetescausesinsulin resistance

by FRUCTOSE , not glucose , and that glucose alone causes insulin to spike(passive) is caused byinsulin resistance

a high carb / fructose dietcausesinsulin resistance

by eating too many sugars , grains and especially fructose(passive) caused byinsulin resistance

eating too many sugars , grains and especially fructose(passive) caused byinsulin resistance

fat ... insulincausesinsulin - resistance

by insulin receptors that don?t respond properly , not by too many carbohydrates in the diet(passive) is caused byinsulin resistance

excess fructose consumption(passive) is caused byInsulin resistance

diabetescausesdiabetes

in type 2 diabetic issuesmay resultin type 2 diabetic issues

to type two diabetesleadto type two diabetes

to the development of type II diabetescontributesto the development of type II diabetes

of patientsmay resultof patients

to Type 2 Complications Of Diabetesto leadto Type 2 Complications Of Diabetes

stubborn weight gain around theto causestubborn weight gain around the

stubborn weight gain around the abdomento causestubborn weight gain around the abdomen

in a cluster of abnormalities known as metabolic syndrome as well as putting on weight round the middle and chronic inflammationresultsin a cluster of abnormalities known as metabolic syndrome as well as putting on weight round the middle and chronic inflammation

to hepatic steatosisleadsto hepatic steatosis

fat storage in the love handlesto causefat storage in the love handles

the rise in type 1 as well as type 2 diabeteshave causedthe rise in type 1 as well as type 2 diabetes

blood clotting , which over time can lead to blocked coronary arteriesto causeblood clotting , which over time can lead to blocked coronary arteries

to Type 2 diabetesleadsto Type 2 diabetes

to very high daily insulin requirementsleadingto very high daily insulin requirements

to decreased production of insulin or the inability of the body to use it efficientlyleadsto decreased production of insulin or the inability of the body to use it efficiently

in diabetesresultsin diabetes

to a state of hyperglycemialeadingto a state of hyperglycemia

to defective glucose utilizationleadingto defective glucose utilization

to diabetic dyslipidemialeadsto diabetic dyslipidemia

glucose intolerance , which has been associated with fat gain , increased triglycerides , and the development of diabetescan causeglucose intolerance , which has been associated with fat gain , increased triglycerides , and the development of diabetes

to high levels of blood insulin and blood sugar , which can lead to Type 2 diabetescould also leadto high levels of blood insulin and blood sugar , which can lead to Type 2 diabetes

high blood sugarto causehigh blood sugar

to increase in blood sugar levels , high triglycerides , high uric acid , fatty liver , weight gain , obesity and Type 2 Diabetesleadingto increase in blood sugar levels , high triglycerides , high uric acid , fatty liver , weight gain , obesity and Type 2 Diabetes

to gestational diabetes , pre - diabetes and eventually type 2 diabetescan leadto gestational diabetes , pre - diabetes and eventually type 2 diabetes

the liver to produce excess glucose , which then causes even more insulin insensitivity and can eventually result in type II diabetescan causethe liver to produce excess glucose , which then causes even more insulin insensitivity and can eventually result in type II diabetes

to high blood pressure , rising triglycerides and cholesterol ... and then metabolic syndrome ( obesity and type 2 diabetesleadsto high blood pressure , rising triglycerides and cholesterol ... and then metabolic syndrome ( obesity and type 2 diabetes

to elevated insulin levels in the blood and an increased risk of diabetesleadsto elevated insulin levels in the blood and an increased risk of diabetes

weight gain , diabetes , and inflammation over timecan causeweight gain , diabetes , and inflammation over time

to pre - diabetes and Type 2 diabetesleadsto pre - diabetes and Type 2 diabetes

to pre - diabetes and then to Type 2 Diabetescan leadto pre - diabetes and then to Type 2 Diabetes

hyperglycemia , impaired immunity , endothelial integrity and an increased risk of infectioncauseshyperglycemia , impaired immunity , endothelial integrity and an increased risk of infection

to elevated blood levels of insulin ( hyperinsulinemia ) and elevated blood levels of glucose , which can ultimately cause heart disease and/or diabetescan leadto elevated blood levels of insulin ( hyperinsulinemia ) and elevated blood levels of glucose , which can ultimately cause heart disease and/or diabetes

to extra glucose in the body which ultimately causes diabetesleadingto extra glucose in the body which ultimately causes diabetes

to metabolic syndrome , obesity and Type 2 Diabetesleadsto metabolic syndrome , obesity and Type 2 Diabetes

to type 2 diabetes , a condition where your body is unable to use insulin to control glucose levels from foodcan leadto type 2 diabetes , a condition where your body is unable to use insulin to control glucose levels from food

to the metabolic syndrome , one of the symptoms of which is hyperinsulinemia , and eventually diabetesleadingto the metabolic syndrome , one of the symptoms of which is hyperinsulinemia , and eventually diabetes

in high blood pressure , abnormal cholesterol and / or triglycerides , obesity , gout , heart disease , stroke , and diabetesresultsin high blood pressure , abnormal cholesterol and / or triglycerides , obesity , gout , heart disease , stroke , and diabetes

to increased insulin and glucose levels in the bloodalso leadsto increased insulin and glucose levels in the blood

to impaired glucose tolerance and type 2 diabetesleadingto impaired glucose tolerance and type 2 diabetes

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