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Qaagi - Book of Why

Causes

Effects

the duplicate Matteucci ’s experiments ... ended updiscoveringthe nerve 's action potential

4 Decreased conductance of sodiumcausesinactivation of the action potential

High K concentrationcausesdepolarization ( action potential

extracellular sodiumthus preventingdepolarisation of the action potential

neuronal activity ( TTXpreventspresynaptic action potential

a release of ACh ( Acetylcholine ) at the synaptic cleft ( 1causesa depolarization ( Action Potential

Either persistent inward current ( for example , through sodium channels ) or reduced outward current ( through potassium channelscan causeprolongation of the action potential

Exposure of isolated myocytes to HNE and acroleincausesprolongation of the action potential

Block of hERG channelcausesprolongation of action potential

from decreased inactivation of the inward Na+ or Ca2 + currents , increased activation of the Ca2 + current , or inhibition of one or more of the outward K+ currentscan resultfrom decreased inactivation of the inward Na+ or Ca2 + currents , increased activation of the Ca2 + current , or inhibition of one or more of the outward K+ currents

activation of calcium currentcausesactivation of calcium current

to as much as 50 % of the [ Na+]i overload associated with the increase in late INa caused by ATX - IIcontributesto as much as 50 % of the [ Na+]i overload associated with the increase in late INa caused by ATX - II

in increased magnitude of Ca2 + influx via l - type Ca2 + channelscan resultin increased magnitude of Ca2 + influx via l - type Ca2 + channels

release of Ca^+ from internal stores which activates a different class of K+ channeltriggersrelease of Ca^+ from internal stores which activates a different class of K+ channel

the occurrence of " early afterdepolarizations " , inducing arrhythmiascan causethe occurrence of " early afterdepolarizations " , inducing arrhythmias

Ventricular arrhythmia(passive) may be caused byVentricular arrhythmia

in the lower values of R and fo in MR - PM compared with MR - FWresultsin the lower values of R and fo in MR - PM compared with MR - FW

in slowly developing increases in the magnitude of Ca2 + transientsalso resultedin slowly developing increases in the magnitude of Ca2 + transients

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