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Qaagi - Book of Why

Causes

Effects

Symptoms and Signs Familial amyloid polyneuropathycausesa length - dependent sensorimotor and autonomic neuropathy

The most common effects on the nervous systemresultfrom a length dependent neuropathy

INH , pyridoxine ( > 200 mg / d over several monthscauseslength - dependent neuropathy and

Vinblastine is knownto causedose - dependent sensorimotor neuropathy

damage to the nerves controlling digestion ... bowel emptying , bladder emptying , sweating , blood pressure and heart rate causing nausea , diarrhea , fainting , dizziness , low blood pressure , and difficulty in swallowing Femoral(passive) is caused byfeet Autonomic neuropathy

Vincristinemost commonly causesa length dependent sensory and/or motor neuropathy

These two conditions tendto causea symmetric , length - dependent sensory neuropathy

From the electrophysiological standpoint , thalidomide is most frequently reportedto causea length - dependent axonal neuropathy

a partially closed glottisresultingin a symmetric length - dependent neuropathy

to osteolysis and demineralization of bone ( 4leadto osteolysis and demineralization of bone ( 4

a decreased ability to move and feel due to nerve damagecausesa decreased ability to move and feel due to nerve damage

increased sweatingmay causeincreased sweating

a progressive deterioration of foot joints(passive) caused bya progressive deterioration of foot joints

reduced tactile sensation primarily in the extremities , which dramatically impacts quality of life through reduced sensory feedback and motor controlcausesreduced tactile sensation primarily in the extremities , which dramatically impacts quality of life through reduced sensory feedback and motor control

a form of small fiber neuropathy that is not length- dependent.4,8,10can causea form of small fiber neuropathy that is not length- dependent.4,8,10

in hyporeflexia ( decreased reflexes ) in the distal limbsresultingin hyporeflexia ( decreased reflexes ) in the distal limbs

the resultsmay have influencedthe results

delayed gastric empty - ing , diarrhoea and postural hypotension.• Clinical manifestations of neuropathy appear late in the course of CRFmay causedelayed gastric empty - ing , diarrhoea and postural hypotension.• Clinical manifestations of neuropathy appear late in the course of CRF

to diminished sweatsecretionleadsto diminished sweatsecretion

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