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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

increased culture(passive) was mainly caused byLactate production increase

conditionscausinglactate growth

as hepatic metabolism will be decreasedresultingin increased lactate

to anaerobic metabolismleadsto increased lactate

by increased glycolysis in cancer cells(passive) caused byincreased lactate

metabolismleadsto increased lactate

tissue hypoxia(passive) caused byincreased lactate

it is increased behaviourcausingthe increased lactate

Not enough mitochondria from any mechanismwill causeincreased lactate

glycolysisleadsto increased lactate

energy metabolism ... mitochondrial respiration towards glycolysiswill ... leadto increased lactate

by metformin(passive) caused byan increase in lactate

For exampleleadsto increased lactate

controlsis increased behaviourcausingthe increased lactate

Adrenaline infusioncommonly leadsto increased lactate

hypovolemia / hypoperfusion / hypoxiadoes ... causean increase in Lactate

EARS2 mutations(passive) caused byhigh lactate ' LTBL

surgery and the factorscausehigh lactate

by novel mutations in the EARS2 gene(passive) caused byhigh lactate

many disorders and diseasescausehigh lactate

While not specific for sepsiswill causelactate release

hypoperfusion ( shockcauseslactate to rise

gut dysbiosis(passive) is caused byhigh lactate

Hyperventilationcausesa rise in lactate

hypoxemia ( e.g. hypoperfusion(passive) is causedhigh lactate

by anaerobic metabolism(passive) caused bylactate accumulation

aerobic metabolismcausinglactate accumulation

Liver ischaemia induced by handling of the liver during surgery and temporary inflow occlusion has been shownto leadto a rise in lactate

conditionscausinglactate accumulation

Metformincauseslactate accumulation

hypoxic mitochondrial dysfunctioncauseslactate accumulation

The processcauseslactate buildup

Intense physical exercisecauseslactate buildup

any process which causes tissue to use anaerobic respiration(passive) can be caused byA raised lactate

other disorderscauseoverproduction of lactate

lots of conditionscauseelevated lactate

Mitochondrial functionmay ... be causinglactate elevation

venous stasismay causelactate elevation

of two subunits ( LDHA and LDHB(passive) is composedLactate dehydrogenase

a disease or conditionis causinglactate to accumulate

muscular fatiguecausesmuscular fatigue

acidosis in any body fluidcausesacidosis in any body fluid

the acidosismay ... causethe acidosis

Both myalgia and encephalopathy(passive) can be caused byBoth myalgia and encephalopathy

nauseacan causenausea

from exerciseresultingfrom exercise

muscles to stop workingcausesmuscles to stop working

from a combination of excess formation and decreased utilization of lactateresultsfrom a combination of excess formation and decreased utilization of lactate

to physical fatigueleadsto physical fatigue

additional neuronal dysfunctioncan causeadditional neuronal dysfunction

muscular fatiguedoes ... causemuscular fatigue

only from pyruvateoriginatesonly from pyruvate

in pyruvate accumulation in cancer cellsalso resultsin pyruvate accumulation in cancer cells

muscular paincausesmuscular pain

vasodilation in vitrocausesvasodilation in vitro

from a combination of excess formationresultsfrom a combination of excess formation

during exercisecausesduring exercise

to the dreaded muscle burnwould ... leadto the dreaded muscle burn

The illness(passive) is caused byThe illness

to acidification of the mediacan leadto acidification of the media

depletion of bicarbonate , elevated anion gap , and metabolic acidosis in a processcausesdepletion of bicarbonate , elevated anion gap , and metabolic acidosis in a process

microenvironmental acidificationcausesmicroenvironmental acidification

depletion of bicarbonate , elevated anion gap , and metabolic acidosiscausesdepletion of bicarbonate , elevated anion gap , and metabolic acidosis

to panic attacks and anxietycould leadto panic attacks and anxiety

acidification of culture medium and lead to high osmolality and low viabilitycan causeacidification of culture medium and lead to high osmolality and low viability

depletion of bicarbonate , elevated anion gapcausesdepletion of bicarbonate , elevated anion gap

depletion of bicarbonatecausesdepletion of bicarbonate

in an improvement in VTresultingin an improvement in VT

a small but significant increase in Hc - O2 affinitycauseda small but significant increase in Hc - O2 affinity

to the anion gapwill also contributeto the anion gap

to the elevated anion gap and the osmolar gapmay contributeto the elevated anion gap and the osmolar gap

to superiorleadsto superior

from glycolysisresultsfrom glycolysis

from penetration by the shunted bloodmay have resultedfrom penetration by the shunted blood

to the NAD(P)H biphasic responsecontributesto the NAD(P)H biphasic response

to decreased tumor cell proliferationleadingto decreased tumor cell proliferation

lactic acidosiscauseslactic acidosis

to higher cellular lactate levelsleadingto higher cellular lactate levels

fatigue ... and there is NO lactate thresholddoes ... causefatigue ... and there is NO lactate threshold

to an elevated lactate / pyruvate ratioleadingto an elevated lactate / pyruvate ratio

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Smart Reasoning:

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