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Qaagi - Book of Why

Causes

Effects

by oxygen debt(passive) caused byhigh lactate levels

hypoxiacausinghigh lactate levels

Certain medications , including metformin and HIV drugscan causehigh lactate levels

conditionscausinglactate growth

tissue hypoxia(passive) caused byincreased lactate

the switch to anaerobic metabolismleadsto higher lactate

Quick relax times are the bestcausea lot of lactate

Short break periods are the topcausea lot of lactate

EARS2 mutations(passive) caused byhigh lactate ' LTBL

by EARS2 mutations(passive) caused byhigh lactate ' LTBL

by poor end organ perfusion(passive) is ... causedthat high of lactate

surgery and the factorscausehigh lactate

by novel mutations in the EARS2 gene(passive) caused byhigh lactate

many disorders and diseasescausehigh lactate

Thiamin deficiencycauseshigh lactate

hypoperfusion ( shockcauseslactate to rise

gut dysbiosis(passive) is caused byhigh lactate

hypoxemia ( e.g. hypoperfusion(passive) is causedhigh lactate

Any process that causes tissue hypoperfusion and subsequent anaerobic metabolismcan leadto an elevated lactate

anaerobic metabolism occurring in muscle cells during strenuous exercise(passive) can be caused byExcess lactate

any process which causes tissue to use anaerobic respiration(passive) can be caused byA raised lactate

conditionscan causehigh levels of lactate

lots of conditionscauseelevated lactate

What drugscan causean elevated lactate

a prescription ... conditionscan causehigh levels of lactate

Mitochondrial functionmay ... be causinglactate elevation

both methanol and ethylene glycolmay causean elevated lactate

delirium and end organ perfusion deficitcausingthe elevated lactate

a number of conditionscan causehigh levels of lactate

venous stasismay causelactate elevation

Short rest periods are the most effectivecausea large amount of lactate

Short rest periods are the bestcausea large amount of lactate

Short rest periods are the very best as a result ofcausea large amount of lactate

Short rest periods are the best as a result ofcausea large amount of lactate

Short rest intervals are the very bestcausea large amount of lactate

Short rest intervals are the bestcausea large amount of lactate

Short rest intervals are the best as a result ofcausea large amount of lactate

Short rest intervals are the very best as a result ofcausea large amount of lactate

Simple rest intervals are the bestcausea large amount of lactate

Brief rest periods are the most effectivecausea large amount of lactate

to higher acidity in muscle , which leads to fatigueleadto higher acidity in muscle , which leads to fatigue

an increase in the acidity of your muscle cellscausesan increase in the acidity of your muscle cells

from mitochondrial dysfunction and multiple sclerosis ( MS ) progressionresultingfrom mitochondrial dysfunction and multiple sclerosis ( MS ) progression

muscle cramping , fatigue and brain fogcan causemuscle cramping , fatigue and brain fog

muscle cramping , fatigue and brain fogcan causemuscle cramping , fatigue and brain fog

a blood culture , which in this situation is much more likely to yield a contaminant that prompts administration of unnecessary antibiotics and can prolong hospital length of stayprompteda blood culture , which in this situation is much more likely to yield a contaminant that prompts administration of unnecessary antibiotics and can prolong hospital length of stay

fatiguecausesfatigue

muscle cramping fatigue and brain fogcan causemuscle cramping fatigue and brain fog

to decreased pressure and t fatigueleadingto decreased pressure and t fatigue

the low(passive) caused bythe low

metabolic acidosis : A ) Type A ( due to reduced O2 deliverycausedmetabolic acidosis : A ) Type A ( due to reduced O2 delivery

acidosis and encephalopathycan causeacidosis and encephalopathy

the low pH(passive) caused bythe low pH

FrequentlycausesFrequently

to neurological issuesleadsto neurological issues

on survivaladversely influencedon survival

other side effects not listed belowmay causeother side effects not listed below

muscles to stop workingcausesmuscles to stop working

additional neuronal dysfunctioncan causeadditional neuronal dysfunction

only from pyruvateoriginatesonly from pyruvate

vasodilation in vitrocausesvasodilation in vitro

a small but significant increase in Hc - O2 affinitycauseda small but significant increase in Hc - O2 affinity

to the anion gapwill also contributeto the anion gap

to the elevated anion gap and the osmolar gapmay contributeto the elevated anion gap and the osmolar gap

to superiorleadsto superior

from glycolysisresultsfrom glycolysis

to the NAD(P)H biphasic responsecontributesto the NAD(P)H biphasic response

to decreased tumor cell proliferationleadingto decreased tumor cell proliferation

to higher cellular lactate levelsleadingto higher cellular lactate levels

fatigue ... and there is NO lactate thresholddoes ... causefatigue ... and there is NO lactate threshold

to an elevated lactate / pyruvate ratioleadingto an elevated lactate / pyruvate ratio

from many other causes including recent exercise , and generalized shockcan resultfrom many other causes including recent exercise , and generalized shock

the hydrogen ions in the muscle to increasecausesthe hydrogen ions in the muscle to increase

to rapid fatigue if the lactate is not removedleadsto rapid fatigue if the lactate is not removed

to rapid fatigue if the lactate is not removed it should beleadsto rapid fatigue if the lactate is not removed it should be

to lactic acidosis ( serum pHmay leadto lactic acidosis ( serum pH

in issues in Individuals who have poor D - lactate metabolismcan resultin issues in Individuals who have poor D - lactate metabolism

to intracellular acidosisleadsto intracellular acidosis

pain when it accumulates in musclescan causepain when it accumulates in muscles

muscle fatigue and paincan causemuscle fatigue and pain

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